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Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property
3-star hotel near Mayo Clinic Florida

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Photo gallery for Residence Inn By Marriott Jacksonville - Mayo Clinic Area

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
Reception

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pet friendly
  • Parking included
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL, 32224
  • Place, University of North Florida
    ‪5 min drive‬
  • Place, St. Johns Town Center
    ‪8 min drive‬
  • Place, Mayport Naval Station
    ‪24 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪34 min drive‬

Room options

View all photos for Studio, 1 King Bed with Sofa bed, Corner

A modern hotel room with a bed, desk, chair, TV, and large windows with curtains.

Studio, 1 King Bed with Sofa bed, Corner

9.8 out of 10
Exceptional
(6 reviews)
  • 533 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom, Corner

A modern kitchen with wooden cabinets, a dishwasher, and a countertop with kitchenware. There is a dining area with a table and chairs, and a living room with a sofa and a TV on the wall.

Studio Suite, 1 Bedroom, Corner

10.0 out of 10
Exceptional
(3 reviews)
  • 646 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed

A modern kitchen with wooden cabinets, a built-in microwave, and a dishwasher.

Studio Suite, 1 King Bed with Sofa bed

9.6 out of 10
Exceptional
(97 reviews)
  • 407 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom

A modern hotel room with a grey sofa, a small round table, a desk with a chair, and a flat-screen TV mounted on the wall.

Studio Suite, 1 Bedroom

9.8 out of 10
Exceptional
(23 reviews)
  • 560 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

9.0 out of 10
Wonderful
(8 reviews)
  • 409 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)
  • 391 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

  • 391 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom (Hearing Accessible)

A modern hotel room with a sofa, desk, and kitchenette.

Studio Suite, 1 Bedroom (Hearing Accessible)

8.0 out of 10
Very good
(1 review)
  • 569 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

A modern hotel room with a bed, desk, chair, TV, and large windows with curtains.

Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)
  • 538 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

A modern hotel room with a sofa, desk, and kitchenette.

Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

  • 641 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

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About the neighborhood

Jacksonville

Isle of Palms stay.A stay at this Isle of Palms hotel places you within 3 miles (5 km) of Mayo Clinic Florida and 6 miles (10 km) of University of North Florida. Windsor Commons Shopping Center and Windsor Parke Golf Club are also within 6 miles (10 km).

What's nearby

  • University of North Florida - 5 min drive - 5.6 miles
  • St. Johns Town Center - 8 min drive - 7.9 miles
  • Jacksonville Beach Pier - 11 min drive - 6.5 miles
  • EverBank Stadium - 21 min drive - 19.0 miles
  • Mayport Naval Station - 24 min drive - 11.6 miles

Getting around

  • Jacksonville, FL (CRG-Jacksonville Executive at Craig) - 17 min drive

Restaurants

  • ‪Culver’s - ‬4 min drive
  • ‪Circle K - ‬9 min walk
  • ‪Starbucks - ‬4 min drive
  • ‪Mayo Clinic - Employee Cafeteria - ‬18 min walk
  • ‪M Brothers at Mayo - ‬17 min walk

About this property

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3-star hotel near Mayo Clinic Florida
Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers its guests an outdoor pool and a 24-hour fitness center. You can enjoy a drink at one of the bars, which include a poolside bar and a bar/lounge. Free breakfast is served daily. A computer station is on site and WiFi is free in public spaces.

A 24-hour business center, 2 meeting rooms, and coworking spaces are available. Event space at this hotel measures 2678 square feet (249 square meters) and includes conference space. Barbecue grills, multilingual staff, and a garden are also featured at the business-friendly Residence Inn By Marriott Jacksonville - Mayo Clinic Area. Self parking is free.

This 3-star Jacksonville hotel is smoke free.

  • 1 building
  • 155 guestrooms or units
  • 7 levels
  • 2678 sq ft of conference space
  • 249 sq m of conference space
  • Built in 2020
  • Buffet breakfast (free)
  • Poolside lounge chairs
  • Business center (24 hours)
  • Conference space
  • Coffee in lobby
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Express check-out
  • Staff is multilingual
  • Storage area for luggage
  • Front-desk safe
  • Concierge
  • Grocery service (free)
  • Wedding services available
  • Convenience store
  • Garden
  • BBQ grill(s)
  • Outdoor picnic space
  • Newspapers in lobby (free)
  • Fireplace in lobby
  • Television in lobby
  • Elevator
  • No smoking on site
  • Water dispenser
  • Bar or lounge
  • Bar by the pool
Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers 155 air-conditioned accommodations with laptop-compatible safes and coffee/tea makers. Accommodations offer separate sitting areas. 55-inch Smart televisions come with premium cable channels and Netflix. Accommodations at this 3-star hotel have kitchens with refrigerators, stovetops, microwaves, and separate dining areas. Bathrooms include bathtubs or showers, complimentary toiletries, and hair dryers.

This Jacksonville hotel provides complimentary wireless Internet access. Business-friendly amenities include desks and phones. Additionally, rooms include irons/ironing boards and blackout drapes/curtains. Housekeeping is offered daily and change of bedsheets can be requested. Housekeeping is provided on request.

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Aug 2 - Aug 3
Total with taxes and fees
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Property amenities

Family friendly

  • Grocery/convenience store
  • In-room kitchen
  • In-room microwave
  • In-room refrigerator
  • Laundry facilities
  • Outdoor pool
  • Separate in-room dining area

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free uncovered self parking on site
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available 6:30 AM to 9:00 AM on weekdays and 7:00 AM to 9:30 AM on weekends
  • A bar/lounge
  • A poolside bar
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Outdoor pool
  • TV in common areas

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Accessible bathtub
  • Assistive listening devices
  • Assistive listening devices in meeting rooms
  • Bathroom emergency pull cord
  • Braille/raised signage
  • Elevator
  • Grab bar near toilet
  • Hand-held showerhead
  • Handrails in stairways
  • Height-adjustable showerhead
  • Lever door handles
  • Low-height bed
  • Low-height counter and sink
  • Low-height door lock
  • Low-height electrical outlets in bathroom
  • Low-height view port in door
  • Phone accessibility kit
  • Pool hoist on site
  • Raised toilet seat
  • Stair-free path to entrance
  • Vibrating pillow alarm
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible business center
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible van parking
  • Wheelchair-width doorways

Room amenities

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathtub or shower
  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Food and drink

  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Kitchen
  • Microwave
  • Refrigerator
  • Separate dining area
  • Stovetop
  • Toaster

More

  • Air conditioning
  • Connecting rooms available
  • Desk
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Separate sitting area
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 6:00 AM
Contactless check-in available
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 150 per accommodation, per stay
  • Only dogs and cats are allowed
  • Maximum 2 (weight limit: 40 lbs per pet)
  • Restrictions apply
  • For more information, you can reach out to the property at the number on the booking confirmation
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Deposit: USD 125 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Pet fee: USD 150 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott)
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, American Express, Discover, and Diners Club. Cash is not accepted. For guests' safety, the property includes a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards in each accommodation. Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device. This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott).

We should mention

  • Registered guests are the only ones allowed to be in guestrooms.
  • Connecting/adjoining rooms are subject to availability and can be requested by contacting the property at the number on your booking confirmation.
  • To make arrangements to bring your pet, contact the property directly at the number on your booking confirmation (please see the Fees section for related charges).
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Residence INN BY Marriott Jacksonville
Residence Inn by Marriott Jacksonville East
Residence Inn Jacksonville Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area Hotel

Frequently asked questions

How close is Residence Inn By Marriott Jacksonville - Mayo Clinic Area to the airport?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area is 11.2 mi (17-min drive) away from the Jacksonville, FL (CRG-Jacksonville Executive at Craig) airport, the closest popular airport to the property.

How much does it cost to stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

As of Jul 12, 2026, prices found for a 1-night stay for 2 adults at Residence Inn By Marriott Jacksonville - Mayo Clinic Area on Aug 8, 2026 start from $150, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have an airport shuttle?

Airport shuttle services are not available at Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How close is Residence Inn By Marriott Jacksonville - Mayo Clinic Area to the beach?

This hotel is 4.4 mi (10-min drive) from Atlantic Beach and 5.4 mi (9-min drive) from Northeast Florida Beaches. Don't forget your sunscreen!

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area offer free breakfast?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers free buffet breakfast on weekdays between 6:30 AM and 9:00 AM and weekends between 7:00 AM and 9:30 AM.

Is there a casino at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

No, there is no casino at this hotel.

What time is check-in at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Check-in start time: 4:00 PM; Check-in end time: 6:00 AM.

Is there free parking at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

This hotel offers free self parking.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have a pool?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area features an outdoor pool.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have a spa?

There are no spa services available at this hotel.

How close is Residence Inn By Marriott Jacksonville - Mayo Clinic Area to downtown Jacksonville?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area is 14.1 mi away from Jacksonville.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 446 out of 556 reviews
Rating 8 - Good. 74 out of 556 reviews
Rating 6 - Okay. 14 out of 556 reviews
Rating 4 - Poor. 14 out of 556 reviews
Rating 2 - Terrible. 8 out of 556 reviews

9.6/10

Cleanliness

9.6/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

Reviews

Verified

8/10 Good

Nancy

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean room, staff were very helpful, room was comfortable
Stayed 2 nights in Apr 2026
Verified

10/10 Excellent

Sabrena

Great stay! Clean room, friendly staff.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

STEVEN

Liked: Cleanliness, staff & service, amenities
Conveniently located, clean rooms, excellent breakfast
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Anthony

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean and well equipped room. Very good buffet breakfast
Stayed 3 nights in Apr 2026
Verified

10/10 Excellent

Darlene

Liked: Cleanliness, amenities, property conditions & facilities
Clean room, amazing staff great location
Stayed 1 night in Dec 2025
Verified

8/10 Good

M

Liked: Cleanliness, staff & service, property conditions & facilities
Good location to multiple attractions in the city. Love the free and easily accessible parking.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

JOHN

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Breakfast was ok nothing special but the staff were all helpful and upbeat. Would highly recommend this property especially if you’re going to Mayo Clinic.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Teresa

Liked: Amenities, property conditions & facilities
Everything was wonderful. I recommend this property.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Astraes

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved the size of the rooms, the kitchen, the amazing breakfast and the helpful staff. Only complaint would be to have more towels available.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Vivien

Liked: Cleanliness, amenities, property conditions & facilities
Gret Hotel
Stayed 6 nights in Feb 2026
Verified

10/10 Excellent

Raymond

Liked: Cleanliness, staff & service, amenities
Wonderful room, clean and comfortable. The staff is great
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

james

Liked: Cleanliness, staff & service, property conditions & facilities
Excellent place to Stay!!
Stayed 1 night in Jul 2025
Verified

10/10 Excellent

Priscilla

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Quality throughout the hotel. Open front lounge area with comfortable seating and lighting. Parking lot has great lighting and access to facility. Transportation available to and from Mayo Clinic.
Stayed 2 nights in Apr 2026
Verified

10/10 Excellent

Stephen

Liked: Cleanliness, amenities, property conditions & facilities
Great room
Stayed 1 night in Feb 2026
Verified

8/10 Good

Kimberly

Liked: Cleanliness, staff & service, amenities
Clean rooms and amenities.
Stayed 4 nights in Jan 2026
Verified

10/10 Excellent

Gary

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great facility to stay.
Stayed 1 night in Sep 2025
Verified

10/10 Excellent

Kay

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Always comfortable, beautiful rooms, great beds, great service, spotless clean
Stayed 1 night in Oct 2025
Verified

10/10 Excellent

Bonnie

Liked: Cleanliness, staff & service, property conditions & facilities
Very nice hotel - clean, quiet and the most convenient to the Mayo Clinic.
Stayed 1 night in Nov 2025
Verified

8/10 Good

Kimberly

Liked: Cleanliness
Staff and amenities
Stayed 5 nights in Jan 2026
Verified

10/10 Excellent

Wayne

Liked: Cleanliness, amenities, property conditions & facilities
The staff was great at check in and the bar. Room was very clean, but the couch needed to be replaced.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Joseph

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Clean, convenient to interstate, Mayo Hospital, 10 minutes from numerous restaurants and shopping. The staff was friendly.
Stayed 1 night in Dec 2025
Verified

8/10 Good

Gerard

Liked: Cleanliness, staff & service, property conditions & facilities
Was perfect place to stay on my visit to Mayo.
Stayed 2 nights in Dec 2024
Verified

10/10 Excellent

Carolyn

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent accommodations!
Stayed 1 night in May 2025
Verified

8/10 Good

Anishma

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved my stay!
Stayed 1 night in Dec 2024
Verified

10/10 Excellent

Carrie

Liked: Cleanliness, amenities, property conditions & facilities
The place was clean and staff was wonderful. Will be staying again!
Stayed 1 night in Jun 2025

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