Book a hotel near Lewis and Clark Interpretive Center, St. Louis
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Top hotels close to Lewis and Clark Interpretive Center

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
6 Gateway Dr Collinsville IL
Free Cancellation
Reserve now, pay when you stay
9.48 mi from Lewis and Clark Interpretive Center
$82 nightly
The price is $95 total per night
$95 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

Super 8 by Wyndham St. Louis North
6200 N Broadway St. Louis MO
Free Cancellation
Reserve now, pay when you stay
10.24 mi from Lewis and Clark Interpretive Center
$77 nightly
The price is $89 total per night
$89 total
Jan 12 - Jan 13, 2026
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the express check-out and onsite conference space. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.
Breakfast included
Parking included

Four Seasons Hotel St Louis
999 North Second Street St. Louis MO
Free Cancellation
12.49 mi from Lewis and Clark Interpretive Center
$415 nightly
The price is $485 total per night
$485 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Families will appreciate kid-friendly dining and in-room childcare. Traveling on business? Take advantage of the 24-hour business center, express check-out, and valet parking.
Pool
Hot Tub

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
333 Washington Ave St. Louis MO
12.74 mi from Lewis and Clark Interpretive Center
$98 nightly
The price is $114 total per night
$114 total
Jan 14 - Jan 15, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Pool
Breakfast included

Marriott St. Louis Grand
800 Washington Ave St. Louis MO
12.81 mi from Lewis and Clark Interpretive Center
$149 nightly
The price is $177 total per night
$177 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. Self parking, a coffee shop, and a snack bar/deli are also offered.
Free WiFi
Restaurant

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
421 N 8th St St. Louis MO
12.85 mi from Lewis and Clark Interpretive Center
$97 nightly
The price is $115 total per night
$115 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. A coffee shop, a snack bar/deli, and a communal living room are also on offer.
Pet friendly
Free WiFi

Home2 Suites by Hilton St. Louis Downtown
1221 Locus Street St. Louis MO
12.9 mi from Lewis and Clark Interpretive Center
$78 nightly
The price is $91 total per night
$91 total
Jan 14 - Jan 15, 2026
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Traveling on business? Take advantage of the 24-hour business center and valet parking. A snack bar/deli and a safe deposit box are also provided.
Breakfast included
Pet friendly

21C Museum Hotel St Louis
1528 Locust street St. Louis MO
12.97 mi from Lewis and Clark Interpretive Center
$148 nightly
The price is $173 total per night
$173 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the gym and conveniences like a 24-hour front desk and concierge services.
Pool
Spa

Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
13 mi from Lewis and Clark Interpretive Center
$129 nightly
The price is $152 total per night
$152 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a rooftop terrace on site, and a 24-hour front desk and a coffee shop are also provided.
Pet friendly
Free WiFi

Drury Plaza Hotel St. Louis at the Arch
2 South 4th Street St. Louis MO
Free Cancellation
Reserve now, pay when you stay
13.09 mi from Lewis and Clark Interpretive Center
$144 nightly
The price is $168 total per night
$168 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free buffet breakfast each morning.
Pool
Hot Tub

Live by Loews - St.Louis
799 Clark ave St. Louis MO
13.26 mi from Lewis and Clark Interpretive Center
$149 nightly
The price is $177 total per night
$177 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. There's a rooftop terrace on site, and concierge services and free newspapers are also offered.
Pet friendly
Free WiFi

Drury Inn & Suites St. Louis Union Station
201 S 20th St St. Louis MO
Free Cancellation
Reserve now, pay when you stay
13.35 mi from Lewis and Clark Interpretive Center
$119 nightly
The price is $142 total per night
$142 total
Jan 14 - Jan 15, 2026
Total with taxes and fees
This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in Lewis and Clark Interpretive Center
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lewis and Clark Interpretive Center hotels essential information
Accommodation | 1,957 hotels |
|---|---|
Lowest Price | $89 |
Highest Price | $485 |
Popular hotels | Hyatt Regency St. Louis at The Arch, Hampton Inn St. Louis-Downtown (At the Gateway Arch), La Quinta Inn & Suites by Wyndham Collinsville - St. Louis, Magnolia Hotel St. Louis, a Tribute Portfolio Hotel, 21C Museum Hotel St Louis , Super 8 by Wyndham St. Louis North, Drury Plaza Hotel St. Louis at the Arch, Home2 Suites by Hilton St. Louis Downtown, Four Seasons Hotel St Louis, Drury Inn & Suites St. Louis Union Station, Marriott St. Louis Grand, Live by Loews - St.Louis |
Recent Lewis and Clark Interpretive Center hotel reviews by fellow wanderers

Live by Loews - St.Louis
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Great view from room. Excellent service from staff."
A verified traveler stayed at Live by Loews - St.Louis
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