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Top hotels in East Seneca

Hampton Inn Buffalo - Amherst, NY

Hampton Inn Buffalo - Amherst, NY

2.5 out of 5
1601 Amherst Manor Drive Buffalo NY
Fully refundableReserve now, pay when you stay
The price is $130 total per night from May 26 to May 27
$130 total
per night
May 26 - May 27
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Staff were all friendly and accomodating, room and property were clean and well maintained. I've stayed there twice now and it has consistantly met my expectations.

Reviewed on May 8, 2026

Opens in a new windowHampton Inn Buffalo - Amherst, NY
Wyndham Garden Buffalo Downtown

Wyndham Garden Buffalo Downtown

3 out of 5
125 High St Buffalo NY
Fully refundableReserve now, pay when you stay
The price is $154 total per night from May 17 to May 18
$154 total
per night
May 17 - May 18
This hotel features a 24-hour gym and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and airport ...
We were there because we had an appointment with Roswell Park. The hotel is conveniently located to the hospital. We were not there to site see. The hotel was nice with a decent breakfast. The staff at this hotel was amazing and most helpful. The gentleman who checked us in was helpful and helped ...

Reviewed on May 8, 2026

Opens in a new windowWyndham Garden Buffalo Downtown
Tru by Hilton Williamsville Buffalo Airport

Tru by Hilton Williamsville Buffalo Airport

2.5 out of 5
48 Freeman Road Buffalo NY
Fully refundableReserve now, pay when you stay
The price is $130 total per night from May 18 to May 19
$130 total
per night
May 18 - May 19
This hotel features an indoor pool and a gym. Relax with a drink at the bar/lounge and enjoy free perks like self-serve breakfast and free self parking. A business ...
Clean room, nice breakfast, free car parking, helpful staff

Reviewed on May 7, 2026

Opens in a new windowTru by Hilton Williamsville Buffalo Airport
La Quinta Inn & Suites by Wyndham Buffalo Amherst

La Quinta Inn & Suites by Wyndham Buffalo Amherst

3 out of 5
145 Innkeepers Lane Buffalo NY
Fully refundableReserve now, pay when you stay
The price is $111 total per night from May 10 to May 11
$111 total
per night
May 10 - May 11
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
The hotel itself is nice and the front desk employee was courteous. I’m sure if we hadn’t found 3 different large blood stains down the side of the bed and the carpet wasn’t damp we might have better things to say. We’d go again but we’ll inspect the room first before going to sleep.

Reviewed on May 5, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Buffalo Amherst
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Fully refundableReserve now, pay when you stay
The price is $110 total per night from May 12 to May 13
$110 total
per night
May 12 - May 13
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Great Staff

Reviewed on May 9, 2026

Opens in a new windowBuffalo Airport Hotel
Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
100 Holtz Dr Buffalo NY
Fully refundable
The price is $103 total per night from May 31 to Jun 1
$103 total
per night
May 31 - Jun 1
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free self parking, and a free airport shuttle. Traveling on business? Take advantage ...
Was a group on our floor that was partying and yelling a screaming until at least 0330. We had to get up at 0430 for a procedure at the hospital and didn’t get hardly any sleep. Not acceptable. I’m reluctant to stay again if this type of activity is happening.

Reviewed on May 8, 2026

Opens in a new windowSleep Inn & Suites Buffalo Airport
La Quinta Inn by Wyndham Buffalo Airport

La Quinta Inn by Wyndham Buffalo Airport

3 out of 5
6619 Transit Rd Buffalo NY
Fully refundableReserve now, pay when you stay
The price is $100 total per night from May 11 to May 12
$100 total
per night
May 11 - May 12
This hotel features a gym and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport ...
I liked how spacious the room was and i really appreciated how clean and organized everything was. I also like there was huge window that brought in alot of natural light. I do want to say that reason i would not a rate it a 5/5 is because the cleaning service was not there every morning to change ...

Reviewed on May 9, 2026

Opens in a new windowLa Quinta Inn by Wyndham Buffalo Airport
Garden Place Hotel

Garden Place Hotel

3.5 out of 5
6615 Transit Road Buffalo NY
Fully refundableReserve now, pay when you stay
The price is $114 total per night from May 12 to May 13
$114 total
per night
May 12 - May 13
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
When you come off the elevator you will notice the wallpaper pulling up in the hallway and the lack of trim between the wall and floor. The room is clean but very basic. You have a bathroom, shower and bed. No USB charging ports so dont forget your wall pieces. No hooks or shelves in the shower for ...

Reviewed on May 6, 2026

Opens in a new windowGarden Place Hotel
M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave Buffalo NY
Fully refundableReserve now, pay when you stay
The price is $125 total per night from May 10 to May 11
$125 total
per night
May 10 - May 11
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport ...
Clean room and price is fair

Reviewed on May 7, 2026

Opens in a new windowM Hotel Buffalo
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

East Seneca Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on East Seneca area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near East Seneca to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near East Seneca are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent East Seneca hotel reviews by fellow wanderers

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