Defiance Vacation Packages 2026 from $557

Defiance flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

The Cheshire

$557

per person

Nov 25 - Nov 28

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.

The Wildwood Hotel

$595

per person

Dec 26 - Dec 30

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Ameristar Casino Resort and Spa

$1,134

per person

Dec 12 - Dec 19

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to St. Louis (STL)

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside bar.

Landing Furnished Apartments - Central West End

Central West End

$752

per person

Jan 3 - Jan 9

found 20 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This apartment features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, barbecue grills, and a virtual front desk are also on offer.

Sheraton Westport Plaza Hotel St. Louis

Westport

$1,288

per person

Jan 3 - Jan 9

found 20 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. Enjoy the gym and perks like free self parking.

Top Defiance hotels deals

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Free Cancellation

Reserve now, pay when you stay

$106 nightly

$126 total

Nov 1 - Nov 2

Total with taxes and fees

A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, express check-out, and free airport shuttle. Relax with a drink at one of the 3 bars/lounges and enjoy perks like free self parking.

Free airport shuttle

Parking included

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

$161 nightly

$188 total

Nov 22 - Nov 23

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside bar.

Pool

Hot Tub

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

13639 Riverport Dr Maryland Heights MO

Free Cancellation

Reserve now, pay when you stay

$83 nightly

$98 total

Oct 28 - Oct 29

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.

Pool

Breakfast included

The Wildwood Hotel

2801 Fountain Pl Wildwood MO

Free Cancellation

Reserve now, pay when you stay

$92 nightly

$107 total

Oct 26 - Oct 27

Total with taxes and fees

Pool

Hot Tub

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

1088 South Highway Drive Fenton MO

Free Cancellation

Reserve now, pay when you stay

$89 nightly

$103 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like full breakfast and free self parking.

Pool

Hot Tub

Sonesta ES Suites St. Louis - Chesterfield

15431 Conway Rd Chesterfield MO

Free Cancellation

Reserve now, pay when you stay

$99 nightly

$115 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. A 24-hour business center, a garden, and express check-out are also on offer.

Pool

Breakfast included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.

See properties

Frequently asked questions

How much are vacation packages to Defiance?

Treat yourself to a one-of-a-kind experience in Defiance with a vacation package starting from just $557. Organizing your hotels, tours and flights with Travelocity is a piece of cake. What's more, our vacation deals will leave you with extra cash for loads of fun times.

Where can I get the best vacation package deals for Defiance?

It's difficult to beat Travelocity when it comes to piecing together your Defiance package deal. There are as many as 400 partner airlines and 1,000,000 properties around the world to choose from. Secure your trip now and get ready to cross another amazing place off your travel bucket list.

Why should I purchase my Defiance vacation package with Travelocity?

From our 24/7 customer care to our range of fantastic destinations, we're committed to fulfilling your travel desires. All you'll have to do is click and book — our Price Match Guarantee will make sure you score the best price.

Can I save on my Defiance car rental if I bundle it with my hotel or flight?

With a Defiance vacation package, you can bundle your hotel, car and flight bookings and save some serious money. If you'd love to discover the best of this wonderful part of the world, why not head to Busch Stadium? This popular attraction is 30 mi from Defiance. With your own rental car, you'll be there before you know it.

Which airport is best for Defiance?

Lambert-St. Louis Intl. Airport (STL) is the top airport for those flying to Defiance. Once you touch down, you'll find yourself 25 mi east of the downtown area.

What is there to do in Defiance?

There is a certain magic in the air as you stroll the streets of Defiance. Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center are just two famous sights that make this city so popular, so put them at the top of your must-see list.

Where should I stay when visiting Defiance?

The BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond is recommended by many travelers. Book soon to avoid missing out.