Explore 6 Luxury Hotels in St. Charles

Name: Ameristar Casino Resort and Spa
Price range: $226 total
Rating: 8.6

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Best Luxury Hotels in St. Charles

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

Fully refundable

$159 total

per night

May 24 - May 25

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. Guests ...

9.4/10 Exceptional! (1,025 reviews)

Good

Reviewed on May 12, 2026

Embassy Suites by Hilton St. Louis St. Charles

2 Convention Center Plz St. Charles MO

Fully refundableReserve now, pay when you stay

$169 total

per night

May 24 - May 25

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the express check-in and WiFi in public areas. Enjoy ...

8.8/10 Excellent! (1,000 reviews)

Very nice hotel I always enjoy myself when I stay however this stay was a little stressful because the AC was not blowing out cold air we called the front desk to see if we could move to a different room or if someone could fix it and they said someone was on the way and 20 mins passed no one showed ...

Reviewed on May 11, 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Fully refundableReserve now, pay when you stay

$226 total

per night

May 17 - May 18

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...

8.6/10 Excellent! (1,011 reviews)

Never ever will go back. Go somewhere else. This was horrible. Went for a mother’s day weekend and the experience was truly awful.

Reviewed on May 10, 2026

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO

Fully refundable

$68 total

per night

May 20 - May 21

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...

6.8/10 (1,000 reviews)

Cleanses and staff was great!

Reviewed on May 11, 2026

Red Roof Inn St Louis - St Charles

2010 Zumbehl Road St. Charles MO

Free self parking is available and the hotel's front desk is staffed around-the-clock. Business travelers can take advantage of the business center. A safe deposit ...

5.4/10 (926 reviews)

Hotel was overbooked, was not incormed of this, paid for 3 rooms days ahead of time only to be told nothing was available upon arrival. Called a few hours before check in to confirm everything and was told everything was ready for my check in.

Reviewed on Mar 29, 2021

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in St. Charles

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

$174 nightly

$206 total

May 31 - Jun 1

Total with taxes and fees

9/10 Wonderful! (1,945 reviews)

5 star hotels in St. Charles

Four Seasons Hotel St Louis

999 North Second Street St. Louis MO

$415 total

per night

May 17 - May 18

9.4/10 Exceptional! (1,001 reviews)

St. Charles Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the St. Charles luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in St. Charles to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in St. Charles will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in St. Charles, and plan your next opulent escape.

St. Charles hotels essential information

Accommodation	2,366 hotels
Lowest Price	$68
Highest Price	$583
Popular hotels	Ameristar Casino Resort and Spa, Country Inn & Suites by Radisson, St. Charles Historic District, Red Roof Inn St Louis - St Charles, Relax Inn Saint Charles , Embassy Suites by Hilton St. Louis St. Charles

Popular Luxury Stays in St. Charles

Recent St. Charles Hotel Reviews By Fellow Wanderers

Pear Tree Inn St. Louis Near Union Station

5 out of 5

Posted 1 hour ago

Travelocity Verified Review

"Good Hotel, good location!"

A verified traveler stayed at Pear Tree Inn St. Louis Near Union Station

Embassy Suites by Hilton St. Louis St. Charles

3 out of 5

Posted 23 hours ago

Travelocity Verified Review

"Very nice hotel I always enjoy myself when I stay however this stay was a little stressful because the AC was not blowing out cold air we called the front desk to see if we could move to a different room or if someone could fix it and they said someone was on the way and 20 mins passed no one showed up and I was exhausted and needed to sleep so I had to deal with the heat all night"

A verified traveler stayed at Embassy Suites by Hilton St. Louis St. Charles