Book Hotels in O Brien, FL

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top O Brien hotels

Postcard Cabins Gilchrist Springs

Postcard Cabins Gilchrist Springs

2 out of 5
1699 NE Co Rd 337, High Springs, FL
$144 nightly
The price is $158 total per night from Sep 29 to Sep 30
$158 total
Sep 29 - Sep 30
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
"We loved our stay at the cabin. Everything was spotless and very well organized. It had absolutely everything you might need to cook and enjoy your time. It was actually our first time making a campfire, and we managed to do it in less than two minutes because everything was so well prepared. Communication ..."

Reviewed on Sep 21, 2025

Opens in a new windowPostcard Cabins Gilchrist Springs
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3 out of 5
3004 West US HWY 90, Lake City, FL
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from Oct 12 to Oct 13
$110 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Free self parking, ...
"The staff was wonderful! The hotel is immaculate and beautifully appointed."

Reviewed on Sep 20, 2025

Opens in a new windowCourtyard By Marriott Lake City
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD, Alachua, FL
Fully refundable
$113 nightly
The price is $127 total per night from Sep 29 to Sep 30
$127 total
Sep 29 - Sep 30
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Very friendly and informative staff. Hotel was updated, clean, amazing comfortable bed."

Reviewed on Sep 25, 2025

Opens in a new windowHoliday Inn Express & Suites Alachua - Gainesville Area by IHG
Comfort Suites Lake City

Comfort Suites Lake City

2.5 out of 5
3690 W Us Highway 90, Lake City, FL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Oct 5 to Oct 6
$105 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"It was a nice and clean property."

Reviewed on Sep 22, 2025

Opens in a new windowComfort Suites Lake City
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

2.5 out of 5
15930 Northwest 163rd Lane, Alachua, FL
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $129 total per night from Sep 28 to Sep 29
$129 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features an outdoor pool and a gym. Business travelers can take advantage of the business center. Free self parking and luggage storage are also offered ...
"It's a new clean and nice hotel"

Reviewed on Sep 8, 2025

Opens in a new windowHampton Inn & Suites Alachua I-75
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

2.5 out of 5
450 SW Florida Gateway Drive, Lake City, FL
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $128 total per night from Sep 28 to Sep 29
$128 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Just want to give a shout out to the manager that helped my daughter after she was in an accident on the interstate. I truly appreciate the staff that helped her out while I traveled to pick her up. We have no family around the area and don’t what we would have done without your help."

Reviewed on Sep 6, 2025

Opens in a new windowHampton Inn & Suites Lake City
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr, Lake City, FL
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $99 total per night from Sep 28 to Sep 29
$99 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"We stayed one night and staff was friendly, room was clean and comfy beds. Will stay here again."

Reviewed on Sep 19, 2025

Opens in a new windowBest Western Plus Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court, Lake City, FL
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $123 total per night from Sep 28 to Sep 29
$123 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"We stopped in to break up a road trip. This property was easy to get to from the highway. It was quiet, and the room was exactly what we needed. The staff was kind. They were working inside the property, so one elevator was down. However, you could see the work that they were doing was going to improve ..."

Reviewed on Sep 22, 2025

Opens in a new windowTru by Hilton Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE, Lake City, FL
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $111 total per night from Sep 28 to Sep 29
$111 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Very friendly staff"

Reviewed on Sep 22, 2025

Opens in a new windowLa Quinta Inn & Suite by Wyndham Lake City
Don't see what you're looking for?
See all available properties in O Brien
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in O Brien?
Family vacations are where treasured memories are made, but traveling with youngsters can be tricky. These kid-friendly O Brien hotels offer perks designed to keep adventurers of all ages relaxed and happy: The whole team will enjoy staying at Cozy OBrien Home w/Fire Pit & Patio Near 3 Rivers. A firepit and free WiFi are just a few of the things that help make this hotel an attractive option. 1 ½ Acre OBrien Home with Fire Pit - Near River! is another top place to stay. After a big day of exploring, return to your comfy room and amenities like a deck and a firepit.
Where can I find cheap hotels in O Brien?
At Travelocity you'll find really nice hotels in O Brien at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near O Brien rather than in O Brien. We may find you even better rates, too.
How do I find the best O Brien hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in O Brien then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in O Brien?
The cheapest hotel in O Brien is $99. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in O Brien?
There are 331 hotels in O Brien on Travelocity.
What are the best hotels in O Brien?
O Brien has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in O Brien for you!
When is the best time to visit O Brien?
If you want the joy of a fun-filled trip in peak season, visit O Brien during March, November and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, April and June.
When is the cheapest time to stay in O Brien?
Based on historic data is usually the cheapest month to visit O Brien. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in O Brien?
There are multiple hotels in O Brien that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to O Brien. We have plenty of kid-friendly hotels in O Brien to choose from on Travelocity!
Why book a hotel in O Brien through Travelocity?
Because we have the top hotels in O Brien! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in O Brien on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent O Brien hotel reviews by fellow wanderers

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Very friendly and informative staff. Hotel was updated, clean, amazing comfortable bed."
A verified traveler stayed at Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Explore More Ways to Travel with Travelocity

Explore More Ways to Travel with Travelocity