Book Hotels in O Brien, FL

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Top O Brien hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien
A gym is featured at this vacation home, along with a garden and laundry facilities. There's fun for all ages with a playground and an arcade/game room, and ...
This was an absolutely delightful house on the water. Plenty of room for the kids to run, it didn't feel sketchy with the river nearby (if you're anxious like me and worried about kids near a river, there's a decent land barrier), tons of stuff to do at the house and nearby, gorgeous area and great ...

Reviewed on Oct 12, 2025

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Opens in a new windowRoyal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

2 out of 5
1699 NE Co Rd 337, High Springs, FL
$149 nightly
The price is $164 total per night from Nov 12 to Nov 13
$164 total
Nov 12 - Nov 13
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
Such a happy experience and makes having a pet even more fun. Can wait to do it again!

Reviewed on Oct 23, 2025

Opens in a new windowPostcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD, Alachua, FL
Fully refundable
$122 nightly
The price is $137 total per night from Nov 12 to Nov 13
$137 total
Nov 12 - Nov 13
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Best hotel in the area. Everything was clean and functional. The staff was very welcoming and friendly, and accommodating. Will definitely return.

Reviewed on Oct 29, 2025

Opens in a new windowHoliday Inn Express & Suites Alachua - Gainesville Area by IHG
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr, Lake City, FL
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $94 total per night from Nov 16 to Nov 17
$94 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
It was perfect, we got in super late an was met with a quick check in an a great breakfast the next day

Reviewed on Nov 7, 2025

Opens in a new windowBest Western Plus Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court, Lake City, FL
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Nov 16 to Nov 17
$98 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
The room was spotless, very comfy bed, pillow and linens. I've been having issues with my knee, so nice to get a tub to relax in!

Reviewed on Oct 31, 2025

Opens in a new windowTru by Hilton Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE, Lake City, FL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Dec 1 to Dec 2
$105 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Fast easy check-in. Wonderfully maintained room. Bathroom was immaculate. Shower had immediate hot water. Bed was very comfortable!

Reviewed on Nov 9, 2025

Opens in a new windowLa Quinta Inn & Suite by Wyndham Lake City
Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG

3 out of 5
213 Sw Commerce Dr, Lake City, FL
Fully refundable
$95 nightly
The price is $107 total per night from Nov 16 to Nov 17
$107 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Clean room and wonderful check in

Reviewed on Nov 8, 2025

Opens in a new windowHoliday Inn & Suites Lake City by IHG
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

2.5 out of 5
6694 Us Highway 129, Live Oak, FL
Fully refundable
$130 nightly
The price is $143 total per night from Nov 18 to Nov 19
$143 total
Nov 18 - Nov 19
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
Could do with touch up on details like paint and corking and grout tiles in bathrooms. For the price your paying. Plus did not like the tv locked for direct tv only, so cant steam your phone to the tv model has, but hotel locked the option

Reviewed on Nov 4, 2025

Opens in a new windowHoliday Inn Express & Suites Live Oak by IHG
Baymont by Wyndham Lake City

Baymont by Wyndham Lake City

2.5 out of 5
3598 W Us Highway 90, Lake City, FL
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $65 total per night from Nov 16 to Nov 17
$65 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the ...
The staff was very friendly and helpful. It was a good cheap overnight stay. Old hotel but beautiful grounds. Clean and quiet. Sorely needs an upgrade, but the price reflects the situation. So fine for a quick overnight stay.

Reviewed on Nov 4, 2025

Opens in a new windowBaymont by Wyndham Lake City
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in O Brien?
Family vacations are where treasured memories are made, but traveling with youngsters can be tricky. These kid-friendly O Brien hotels offer perks designed to keep adventurers of all ages relaxed and happy: The whole team will enjoy staying at Cozy OBrien Home w/Fire Pit & Patio Near 3 Rivers. A firepit and free WiFi are just a few of the things that help make this hotel an attractive option. 1 ½ Acre OBrien Home with Fire Pit - Near River! is another top place to stay. After a big day of exploring, return to your comfy room and amenities like a deck and a firepit.
Where can I find cheap hotels in O Brien?
At Travelocity you'll find really nice hotels in O Brien at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near O Brien rather than in O Brien. We may find you even better rates, too.
How do I find the best O Brien hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in O Brien then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in O Brien?
The cheapest hotel in O Brien is $65. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in O Brien?
There are 341 hotels in O Brien on Travelocity.
What are the best hotels in O Brien?
O Brien has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in O Brien for you!
When is the best time to visit O Brien?
If you want the joy of a fun-filled trip in peak season, visit O Brien during March, November and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, April and June.
When is the cheapest time to stay in O Brien?
Based on historic data is usually the cheapest month to visit O Brien. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in O Brien?
There are multiple hotels in O Brien that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to O Brien. We have plenty of kid-friendly hotels in O Brien to choose from on Travelocity!
Why book a hotel in O Brien through Travelocity?
Because we have the top hotels in O Brien! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in O Brien on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent O Brien hotel reviews by fellow wanderers

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Fast easy check-in. Wonderfully maintained room. Bathroom was immaculate. Shower had immediate hot water. Bed was very comfortable!"
A verified traveler stayed at La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City

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