Book Hotels in O Brien, FL

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Top hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien
This vacation home features a garden, laundry facilities, and barbecue grills. There's fun for all ages with a playground and an arcade/game room.
Camp Callie
"We rented this place for our daughter’s 4th birthday because she wanted to camp, swim, kayak etc… our fave part was setting up the projector movie night and then she camped on the deck with dad. Away from the bugs and grass but still the experience of camping. Pac man was enjoyed by everyone. The ..."

Reviewed on Jun 12, 2025

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Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
Postcard Cabins Gilchrist Springs

Postcard Cabins Gilchrist Springs

2 out of 5
1699 NE Co Rd 337, High Springs, FL
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
"This is one of the most beautiful places I have ever stayed in. The host was very welcoming and we appreciated all the amenities provided. It was an absolute dream to stay there. The design of the cabin is efficient and cozy. I would go back in a heartbeat! Thank you for making this one of the best ..."

Reviewed on Jun 9, 2025

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Postcard Cabins Gilchrist Springs
Comfort Suites Lake City

Comfort Suites Lake City

2.5 out of 5
3690 W Us Highway 90, Lake City, FL
Fully refundableReserve now, pay when you stay
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Stopped for a night for travel to drop off college student"

Reviewed on Jun 17, 2025

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Comfort Suites Lake City
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD, Alachua, FL
Fully refundable
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Clean rooms and quiet"

Reviewed on Jun 17, 2025

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Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr, Lake City, FL
Fully refundableReserve now, pay when you stay
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Lovely"

Reviewed on Jun 17, 2025

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Best Western Plus Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court, Lake City, FL
Fully refundableReserve now, pay when you stay
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Easy overnight stay"

Reviewed on Jun 17, 2025

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Tru by Hilton Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE, Lake City, FL
Fully refundableReserve now, pay when you stay
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Very nice hotel. Clean. Awesome breakfast! Will stay at a La Quinta Inn on our next trip."

Reviewed on Jun 14, 2025

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La Quinta Inn & Suite by Wyndham Lake City
Holiday Inn Express Hotel & Suites LIVE OAK by IHG

Holiday Inn Express Hotel & Suites LIVE OAK by IHG

2.5 out of 5
6694 Us Highway 129, Live Oak, FL
Fully refundable
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
"Muy cerca de la carretera y con varios lugares alrededor donde poder comer. Excelente para hacer una parada y seguir viaje"

Reviewed on Jun 13, 2025

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Holiday Inn Express Hotel & Suites LIVE OAK by IHG
MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

O'Brien
A garden, express check-in, and express check-out are available at this vacation home. Laundry facilities and barbecue grills are also provided.
Stunning get away
"First pulling up on the property I was ready for a relaxing weekend. The 3rd floor porch was an outstanding spot to look over the river. The dock brings you right into the water. When you are looking at the house from the dock it looks like an estate. The neighbors were nice and helped with directions ..."

Reviewed on Apr 28, 2025

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MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
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See all available properties in O Brien
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in O Brien?
Family vacations are where treasured memories are made, but traveling with youngsters can be tricky. These kid-friendly O Brien hotels offer perks designed to keep adventurers of all ages relaxed and happy: The whole team will enjoy staying at Cozy OBrien Home w/Fire Pit & Patio Near 3 Rivers. A firepit and free WiFi are just a few of the things that help make this hotel an attractive option. 1 ½ Acre OBrien Home with Fire Pit - Near River! is another top place to stay. After a big day of exploring, return to your comfy room and amenities like a deck and a firepit.
Where can I find cheap hotels in O Brien?
At Travelocity you'll find really nice hotels in O Brien at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near O Brien rather than in O Brien. We may find you even better rates, too.
How do I find the best O Brien hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in O Brien then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in O Brien?
The cheapest hotel in O Brien is . This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in O Brien?
There are 328 hotels in O Brien on Travelocity.
What are the best hotels in O Brien?
O Brien has so many great hotels to choose from at Travelocity --- and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in O Brien for you!
When is the best time to visit O Brien?
If you want the joy of a fun-filled trip in peak season, visit O Brien during March, November and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, April and June.
When is the cheapest time to stay in O Brien?
Based on historic data is usually the cheapest month to visit O Brien. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in O Brien?
There are multiple hotels in O Brien that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to O Brien. We have plenty of kid-friendly hotels in O Brien to choose from on Travelocity!
Why book a hotel in O Brien through Travelocity?
Because we have the top hotels in O Brien! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in O Brien on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent O Brien hotel reviews by fellow wanderers

Baymont by Wyndham Lake City

Baymont by Wyndham Lake City

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Easy check-in and friendly front desk staff. The room was very clean and the bed was comfy!"
A verified traveler stayed at Baymont by Wyndham Lake City
Baymont by Wyndham Lake City
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