Book Hotels in O Brien, FL
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Top O Brien hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
obrien FL
A gym is featured at this vacation home, along with a garden and laundry facilities. There's fun for all ages with a playground and an arcade/game room, and ...
Very welcoming and personable hosts. They came over to relatives house and had dinner with us. Very relaxed environment with family and friends.
Reviewed on Jan 11, 2026

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
1699 NE Co Rd 337 High Springs FL
$199 nightly
The price is $219 total per night from Feb 10 to Feb 11
$219 total
Feb 10 - Feb 11
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
I stay was amazing. The cabin was clean. The staff have asked us what we need and was very attentive. I will book again. It was an amazing weekend.
Reviewed on Feb 1, 2026

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD Alachua FL
Fully refundable
$108 nightly
The price is $122 total per night from Feb 22 to Feb 23
$122 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Room was spotless and staff was great.
Reviewed on Feb 2, 2026

Courtyard By Marriott Lake City
3004 West US HWY 90 Lake City FL
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $120 total per night from Feb 15 to Feb 16
$120 total
Feb 15 - Feb 16
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Free self parking, ...
All good
Reviewed on Feb 2, 2026

Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $121 total per night from Feb 22 to Feb 23
$121 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Desiree was so pleasant and very accommodating. The bed was very comfortable and the complimentary breakfast was a nice addition.
Reviewed on Jan 30, 2026

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $129 total per night from Feb 15 to Feb 16
$129 total
Feb 15 - Feb 16
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Friendly staff. Clean
Reviewed on Feb 6, 2026

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $116 total per night from Mar 1 to Mar 2
$116 total
Mar 1 - Mar 2
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Love this hotel. The rooms were clean, the staff was friendly. Will stay there again.
Reviewed on Feb 8, 2026

Holiday Inn & Suites Lake City by IHG
213 Sw Commerce Dr Lake City FL
Fully refundable
$93 nightly
The price is $105 total per night from Feb 15 to Feb 16
$105 total
Feb 15 - Feb 16
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
We enjoyed our night in our room.Dinner and breakfast good.
Reviewed on Jan 28, 2026

Holiday Inn Express & Suites Live Oak by IHG
6694 Us Highway 129 Live Oak FL
$121 nightly
The price is $133 total per night from Feb 22 to Feb 23
$133 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
The room was clean. Bed was comfortable. Staff very nice. Breakfast was delicious. Great experience
Reviewed on Feb 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent O Brien hotel reviews by fellow wanderers

La Quinta Inn & Suite by Wyndham Lake City
5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Love this hotel. The rooms were clean, the staff was friendly. Will stay there again."
A verified traveler stayed at La Quinta Inn & Suite by Wyndham Lake City
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