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Top O Brien hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien FL
A gym is featured at this vacation home, along with a garden and laundry facilities. There's fun for all ages with a playground and an arcade/game room, and ...
We had a BEAUTIFUL and relaxing stay at this river rental. Everything was so neat and organized with extras like kayaks, a canoes, games and what not. And it is just 0.5 miles from Royal Springs. The owners were quick to respond to any questions we had and we even got to meet them while they were ...

Reviewed on Mar 30, 2026

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Opens in a new windowRoyal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

2 out of 5
1699 NE Co Rd 337 High Springs FL
$229 nightly
The price is $252 total per night from May 12 to May 13
$252 total
May 12 - May 13
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
Perfect get away, no WiFi though:(

Reviewed on May 4, 2026

Opens in a new windowPostcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD Alachua FL
Fully refundable
$95 nightly
The price is $107 total per night from May 17 to May 18
$107 total
May 17 - May 18
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
N/A

Reviewed on May 10, 2026

Opens in a new windowHoliday Inn Express & Suites Alachua - Gainesville Area by IHG
Comfort Suites Lake City

Comfort Suites Lake City

2.5 out of 5
3690 W Us Highway 90 Lake City FL
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $130 total per night from May 25 to May 26
$130 total
May 25 - May 26
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
No beach access. Front of hotel under construction- you have to go thru a small plywood area to get inside. No parking and the hotel smells like mold. Nothing like the pictures online. Avoid at all costs. Are son’s asthma is acting up because of how bad the hotel is. So upset that Expedia had this ...

Reviewed on May 9, 2026

Opens in a new windowComfort Suites Lake City
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3 out of 5
3004 West US HWY 90 Lake City FL
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $123 total per night from May 24 to May 25
$123 total
May 24 - May 25
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Free self parking, ...
Clean hotel, nice room, good value.

Reviewed on May 9, 2026

Opens in a new windowCourtyard By Marriott Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $114 total per night from May 31 to Jun 1
$114 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
I came to this hotel because a previous one I had booked was absolutely disgusting. Princess at the front desk was so helpful. She helped me calm down and went out of her way to make sure that I was able to wash and dry my clothes. The hotel itself was extremely nice and very clean. I would recommend ...

Reviewed on May 10, 2026

Opens in a new windowLa Quinta Inn & Suite by Wyndham Lake City
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

2 out of 5
3835 West US Highway 90 Lake City FL
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $76 total per night from May 12 to May 13
$76 total
May 12 - May 13
Total with taxes and fees
An outdoor pool is featured at this motel, along with free self parking. Guests will appreciate free perks like on-the-go breakfast and WiFi in public areas. ...
The staff was very nice and polite and it's very simple to get in.

Reviewed on May 11, 2026

Opens in a new windowAmericas Best Value Inn Lake City
Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

2 out of 5
3340 W US Highway 90 Lake City FL
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $72 total per night from May 13 to May 14
$72 total
May 13 - May 14
Total with taxes and fees
Staff at the 24-hour front desk can provide around-the-clock assistance. Take advantage of the free self parking.
GOOD STOP FOR ONE NIGHT IF BREAKING UP TRAVEL TIME.

Reviewed on May 11, 2026

Opens in a new windowMotel 6 – Lake City, Fl – Medical Center
Little River Spring Cave divers poolside Hideaway

Little River Spring Cave divers poolside Hideaway

O'Brien FL
An outdoor pool is featured at this apartment, along with a garden.
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Opens in a new windowLittle River Spring Cave divers poolside Hideaway
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in O Brien?
Family vacations are where treasured memories are made, but traveling with youngsters can be tricky. These kid-friendly O Brien hotels offer perks designed to keep adventurers of all ages relaxed and happy: The whole team will enjoy staying at Cozy OBrien Home w/Fire Pit & Patio Near 3 Rivers. A firepit and free WiFi are just a few of the things that help make this hotel an attractive option. 1 ½ Acre OBrien Home with Fire Pit - Near River! is another top place to stay. After a big day of exploring, return to your comfy room and amenities like a deck and a firepit.
Where can I find cheap hotels in O Brien?
At Travelocity you'll find really nice hotels in O Brien at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near O Brien rather than in O Brien. We may find you even better rates, too.
How do I find the best O Brien hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in O Brien then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in O Brien?
The cheapest hotel in O Brien is $72. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in O Brien?
There are 377 hotels in O Brien on Travelocity.
What are the best hotels in O Brien?
O Brien has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in O Brien for you!
When is the best time to visit O Brien?
If you want the joy of a fun-filled trip in peak season, visit O Brien during March, November and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, April and June.
When is the cheapest time to stay in O Brien?
Based on historic data is usually the cheapest month to visit O Brien. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in O Brien?
There are multiple hotels in O Brien that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to O Brien. We have plenty of kid-friendly hotels in O Brien to choose from on Travelocity!
Why book a hotel in O Brien through Travelocity?
Because we have the top hotels in O Brien! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in O Brien on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent O Brien hotel reviews by fellow wanderers

Best Western Plus Lake City

Best Western Plus Lake City

5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Quiet Clean &comfortable"
A verified traveler stayed at Best Western Plus Lake City
Best Western Plus Lake City

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