Book Hotels in O Brien, FL
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Top O Brien hotels

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
1699 NE Co Rd 337 High Springs FL
$249 nightly
The price is $274 total per night from Jul 27 to Jul 28
$274 total
Jul 27 - Jul 28
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
"Lo que más me gusta es la naturaleza es preciosa"
Reviewed on Jun 21, 2026

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD Alachua FL
Fully refundable
$96 nightly
The price is $108 total per night from Jul 26 to Jul 27
$108 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"This hotel was super clean, the room was very roomy, and the staff were so friendly and helpful. Also, the included breakfast buffet was awesome."
Reviewed on Jun 24, 2026

Comfort Suites Lake City
3690 W Us Highway 90 Lake City FL
Fully refundable
$103 nightly
The price is $116 total per night from Jul 5 to Jul 6
$116 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"good price, food and relaxing stay"
Reviewed on Jun 22, 2026

Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $123 total per night from Jul 5 to Jul 6
$123 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Friendly staff, nice snack, food options. Clean room."
Reviewed on Jun 24, 2026

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Jun 29 to Jun 30
$98 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Nice room and great breakfast."
Reviewed on Jun 25, 2026

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jun 29 to Jun 30
$106 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Clean room."
Reviewed on Jun 25, 2026

Holiday Inn Express & Suites Live Oak by IHG
6694 Us Highway 129 Live Oak FL
Fully refundable
$114 nightly
The price is $125 total per night from Jul 12 to Jul 13
$125 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Expedia advertised this room as accommodating 5 people, but the hotel staff confirmed that none of their rooms fit more than 4 guests. The staff was very helpful and did their best to minimize the inconvenience. We made it work for one night, but it was frustrating. Be aware of this discrepancy when ..."
Reviewed on Jun 22, 2026

Baymont by Wyndham Lake City I-75
3598 W Us Highway 90 Lake City FL
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $65 total per night from Jun 28 to Jun 29
$65 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the ...
"Not fit for habitation. Dirty, nasty and gross."
Reviewed on Jun 25, 2026

Little River Spring Cave divers poolside Hideaway
O'Brien FL
An outdoor pool is featured at this apartment, along with a garden.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent O Brien hotel reviews by fellow wanderers

Best Western Plus Lake City
5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Nice room and great breakfast."
A verified traveler stayed at Best Western Plus Lake City
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