Book Hotels in O Brien, FL
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top O Brien hotels

Postcard Cabins Gilchrist Springs
1699 NE Co Rd 337, High Springs, FL
$144 nightly
The price is $158 total per night from Oct 7 to Oct 8
$158 total
Oct 7 - Oct 8
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
"Clean cabin. Free firewood and fire starter. Provided utensils and pots and pans. Provided coffee, tea, water, s'mores kit, sticks to put the marshmallows on. Great experience"
Reviewed on Sep 25, 2025

Courtyard By Marriott Lake City
3004 West US HWY 90, Lake City, FL
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from Oct 12 to Oct 13
$110 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Free self parking, ...
"The staff was wonderful! The hotel is immaculate and beautifully appointed."
Reviewed on Sep 20, 2025

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
O'Brien
$360 nightly
The price is $392 total per night from Oct 1 to Oct 2
$392 total
Oct 1 - Oct 2
Total with taxes and fees
A garden, express check-in, and express check-out are available at this vacation home. Laundry facilities and barbecue grills are also provided.
"A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!"
Reviewed on Sep 1, 2025

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD, Alachua, FL
Fully refundable
$117 nightly
The price is $132 total per night from Oct 1 to Oct 2
$132 total
Oct 1 - Oct 2
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Very friendly and informative staff. Hotel was updated, clean, amazing comfortable bed."
Reviewed on Sep 25, 2025

Comfort Suites Lake City
3690 W Us Highway 90, Lake City, FL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Oct 6 to Oct 7
$105 total
Oct 6 - Oct 7
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"I like that it was easy to get into the parking lot and it was right at the end of all the stores and restaurants. The only thing that can make it better is if you didn't have to drive to the convenience store."
Reviewed on Sep 26, 2025

Best Western Plus Lake City
350 SW Florida Gateway Dr, Lake City, FL
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Oct 19 to Oct 20
$100 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Everything was really nice. The front desk staff was on point. I would recommend staying at the Best Western."
Reviewed on Sep 25, 2025

Tru by Hilton Lake City
284 NW Centurion Court, Lake City, FL
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $123 total per night from Oct 12 to Oct 13
$123 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Very nice place!! Very clean ! Comfortable beds ... Nice showers, good breakfast food choices ..."
Reviewed on Sep 27, 2025

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE, Lake City, FL
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $111 total per night from Oct 2 to Oct 3
$111 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Decent room for the price"
Reviewed on Sep 28, 2025

Holiday Inn Express & Suites Live Oak by IHG
6694 Us Highway 129, Live Oak, FL
$130 nightly
The price is $143 total per night from Oct 12 to Oct 13
$143 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
"Nice place"
Reviewed on Sep 23, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent O Brien hotel reviews by fellow wanderers

Hampton Inn & Suites Lake City
5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Service at check in was stellar! They have free EV charging which was a pleasant surprise. They are updating the 1st floor and it’s coming together beautifully. "
A verified traveler stayed at Hampton Inn & Suites Lake City
Explore More Ways to Travel with Travelocity
Explore More Ways to Travel with Travelocity
- Hotels near Lake DeSoto Farmers Market
- Hotels near Troy Spring State Park
- Apartments in Live Oak
- B&B in Live Oak
- Cabins in Live Oak
- Cottages in Live Oak
- Extended Stay Hotels in Live Oak
- Hotels with Pools in Live Oak
- Hotels with Hot Tubs in Live Oak
- Hotels with Restaurants in Live Oak
- Pet Friendly Hotels in Live Oak
- Spa Resorts & in Live Oak
- Live Oak Hotels
- Motels in Live Oak
- Vacation Homes in Live Oak
- Rv Parks in Live Oak
- Hotels near Ichetucknee Springs State Park
- Hotels near Santa Fe River
- Hotels near Ruth B. Kirby Gilchrist Blue Springs State Park
- Hotels near North Florida Speedway
- Hotels near Epiphany Catholic Church
- Hotels near First Federal Sportsplex
- Apartments in Mayo
- Cabins in Mayo
- Condos in Mayo
- Cheap Hotels in Mayo
- Mayo Hotels
- Motels in Mayo
- Vacation Homes in Mayo
- Hotels near Ichetucknee River
- Lake City Hotels
- Resorts in Alton
- Hotels near Florida Department of Transportation
- Hotels near Poe Springs Park
- Hotels near Southside Recreation Complex
- Hotels near Wes Skiles Peacock Springs State Park
- Bell Hotels
- Apartments in Wellborn
- B&B in Wellborn
- Cabins in Wellborn
- Cottages in Wellborn
- Wellborn Hotels
- Motels in Wellborn
- Rv Parks in Wellborn
- Hotels near Lake City Mall
- Hotels near Lafayette Blue Springs State Park
- 3 Star Hotels in Branford
- Cabins in Branford
- Guest Houses in Branford
- Branford Hotels
- Motels in Branford
- Vacation Homes in Branford
- Rv Parks in Branford
- Apartments in Mcalpin
- Mcalpin Hotels
- Motels in Mcalpin
- Rv Parks in Mcalpin
- Hotels near Columbia County Courthouse
- Hotels near Lake City Veterans Affairs Medical Center
- Hotels near Bob's River Place
- Hotels near Ginnie Spring
- Hotels near Lake City Columbia County Historical Museum
- Hotels near Pine Grove Baptist Church
- Apartments in Fort White
- B&B in Fort White
- Cabins in Fort White
- Condos in Fort White
- Cottages in Fort White
- Historic Hotels in Fort White
- Romantic Getaways & Hotels in Fort White
- Fort White Hotels
- Motels in Fort White
- Vacation Homes in Fort White
- Rv Parks in Fort White
- Hotels near Southside Sports Complex
- Flights to Live Oak
- Flights from Atlanta to Live Oak
- Flights from Kansas City to Live Oak
- Flights from Raleigh to Live Oak
- Flights from Madison to Live Oak
- Flights to Mayo
- Flights to Wellborn
- Flights to Branford
- Flights to Fort White
- Flights from Edmonton to Fort White
- Flights from Birmingham to Fort White