Book Hotels in O Brien, FL

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Top O Brien hotels

Postcard Cabins Gilchrist Springs

Postcard Cabins Gilchrist Springs

2 out of 5
1699 NE Co Rd 337, High Springs, FL
$144 nightly
The price is $158 total per night from Oct 7 to Oct 8
$158 total
Oct 7 - Oct 8
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
"Clean cabin. Free firewood and fire starter. Provided utensils and pots and pans. Provided coffee, tea, water, s'mores kit, sticks to put the marshmallows on. Great experience"

Reviewed on Sep 25, 2025

Opens in a new windowPostcard Cabins Gilchrist Springs
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3 out of 5
3004 West US HWY 90, Lake City, FL
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from Oct 12 to Oct 13
$110 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Free self parking, ...
"The staff was wonderful! The hotel is immaculate and beautifully appointed."

Reviewed on Sep 20, 2025

Opens in a new windowCourtyard By Marriott Lake City
MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

O'Brien
$360 nightly
The price is $392 total per night from Oct 1 to Oct 2
$392 total
Oct 1 - Oct 2
Total with taxes and fees
A garden, express check-in, and express check-out are available at this vacation home. Laundry facilities and barbecue grills are also provided.
"A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!"

Reviewed on Sep 1, 2025

Opens in a new windowMARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD, Alachua, FL
Fully refundable
$117 nightly
The price is $132 total per night from Oct 1 to Oct 2
$132 total
Oct 1 - Oct 2
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Very friendly and informative staff. Hotel was updated, clean, amazing comfortable bed."

Reviewed on Sep 25, 2025

Opens in a new windowHoliday Inn Express & Suites Alachua - Gainesville Area by IHG
Comfort Suites Lake City

Comfort Suites Lake City

2.5 out of 5
3690 W Us Highway 90, Lake City, FL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Oct 6 to Oct 7
$105 total
Oct 6 - Oct 7
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"I like that it was easy to get into the parking lot and it was right at the end of all the stores and restaurants. The only thing that can make it better is if you didn't have to drive to the convenience store."

Reviewed on Sep 26, 2025

Opens in a new windowComfort Suites Lake City
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr, Lake City, FL
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Oct 19 to Oct 20
$100 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Everything was really nice. The front desk staff was on point. I would recommend staying at the Best Western."

Reviewed on Sep 25, 2025

Opens in a new windowBest Western Plus Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court, Lake City, FL
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $123 total per night from Oct 12 to Oct 13
$123 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Very nice place!! Very clean ! Comfortable beds ... Nice showers, good breakfast food choices ..."

Reviewed on Sep 27, 2025

Opens in a new windowTru by Hilton Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE, Lake City, FL
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $111 total per night from Oct 2 to Oct 3
$111 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Decent room for the price"

Reviewed on Sep 28, 2025

Opens in a new windowLa Quinta Inn & Suite by Wyndham Lake City
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

2.5 out of 5
6694 Us Highway 129, Live Oak, FL
$130 nightly
The price is $143 total per night from Oct 12 to Oct 13
$143 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
"Nice place"

Reviewed on Sep 23, 2025

Opens in a new windowHoliday Inn Express & Suites Live Oak by IHG
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in O Brien?
Family vacations are where treasured memories are made, but traveling with youngsters can be tricky. These kid-friendly O Brien hotels offer perks designed to keep adventurers of all ages relaxed and happy: The whole team will enjoy staying at Cozy OBrien Home w/Fire Pit & Patio Near 3 Rivers. A firepit and free WiFi are just a few of the things that help make this hotel an attractive option. 1 ½ Acre OBrien Home with Fire Pit - Near River! is another top place to stay. After a big day of exploring, return to your comfy room and amenities like a deck and a firepit.
Where can I find cheap hotels in O Brien?
At Travelocity you'll find really nice hotels in O Brien at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near O Brien rather than in O Brien. We may find you even better rates, too.
How do I find the best O Brien hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in O Brien then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in O Brien?
The cheapest hotel in O Brien is $100. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in O Brien?
There are 330 hotels in O Brien on Travelocity.
What are the best hotels in O Brien?
O Brien has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in O Brien for you!
When is the best time to visit O Brien?
If you want the joy of a fun-filled trip in peak season, visit O Brien during March, November and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, April and June.
When is the cheapest time to stay in O Brien?
Based on historic data is usually the cheapest month to visit O Brien. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in O Brien?
There are multiple hotels in O Brien that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to O Brien. We have plenty of kid-friendly hotels in O Brien to choose from on Travelocity!
Why book a hotel in O Brien through Travelocity?
Because we have the top hotels in O Brien! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in O Brien on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

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