Book Hotels in Clarksdale, MO
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Top Clarksdale hotels

Drury Inn & Suites St Joseph
4213 Frederick Ave St. Joseph MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $127 total per night from Jun 21 to Jun 22
$127 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"We had just stayed at the Drury plaza downtown St. Paul and this makes our review a bit bias. This place was decent, but the pet fee is $50 and we thought it was a bit much. We have an 7 lb. Female pad potty trained chihuahua. The pool area kinda put us off. The place needs ventilation. The 5:30 ..."
Reviewed on Jun 15, 2026

My Place Hotel St Joseph MO
3621 N Village Dr St. Joseph MO
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $100 total per night from Jun 28 to Jun 29
$100 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the 24-hour business center. ...
"Clean room. Great bed. Close to freeway."
Reviewed on Jun 14, 2026

Home2 Suites By Hilton St. Joseph
3701 North Village Drive St. Joseph MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $141 total per night from Jun 28 to Jun 29
$141 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features an indoor pool, a gym, and a restaurant. Business travelers can take advantage of the business center. Guests will appreciate freebies like ...
"Had a great stay!"
Reviewed on Jun 14, 2026

Stoney Creek Hotel St. Joseph
1201 N Woobine Rd St. Joseph MO
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $155 total per night from Jul 12 to Jul 13
$155 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
"Perfect place to relax and enjoy with great amenities"
Reviewed on Jun 15, 2026

Red Roof Inn Cameron
501 Northland Drive Cameron MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $105 total per night from Jul 17 to Jul 18
$105 total
Jul 17 - Jul 18
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like continental breakfast and WiFi ...
"Hall was humid, warm, and smelled damp. Room didn’t have the air on. Room smelled damp the whole 3 days we were there. Room was humid and warm with a/c off at arrival."
Reviewed on Jun 15, 2026

Quality Inn Cameron
1803 Comfort Ln Cameron MO
Fully refundable
$121 nightly
The price is $134 total per night from Jul 17 to Jul 18
$134 total
Jul 17 - Jul 18
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free buffet breakfast each morning. A computer station, luggage ...
"Hotel was clean, staff was courteous, and the price was right."
Reviewed on Jun 13, 2026

SureStay Hotel by Best Western Cameron
2210 US Highway 36 Cameron MO
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Staff at the 24-hour front desk can provide ...
"The staff was friendly enough. I've NEVER had a flyswatter hanging on a thumbtack in a room before. We killed 4 flies. The curtains didn't have enough hooks, so they couldn't completely close. I used a hair clip to secure them. I hope that the spots on the wall was over spray from a soda and not ..."
Reviewed on Jun 1, 2026

Hampton Inn St. Joseph
3928 Frederick Ave St. Joseph MO
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $94 total per night from Jun 28 to Jun 29
$94 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
"Great location"
Reviewed on Jun 14, 2026

Motel 6 Saint Joseph, MO
4021 Frederick Ave St. Joseph MO
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Jun 28 to Jun 29
$84 total
Jun 28 - Jun 29
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. A snack bar/deli and laundry facilities are also provided.
"When i got into the room I has dirty towels and there was dried blood on the pillowcase and the sheet the blanket was also very dirty and it smelled like poop. The outside was very dirty as will. When I went down to tell them I had to wait another 30 minutes 8her and the maid came in she took the ..."
Reviewed on Jun 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Clarksdale hotel reviews by fellow wanderers

Drury Inn & Suites St Joseph
5 out of 5
Posted 9 hours ago
Travelocity Verified Review
"We had just stayed at the Drury plaza downtown St. Paul and this makes our review a bit bias. This place was decent, but the pet fee is $50 and we thought it was a bit much. We have an 7 lb. Female pad potty trained chihuahua. The pool area kinda put us off. The place needs ventilation. The 5:30 snacks&drink time is what sets Drury apart for sure. Good breakfast too! We recommend it, but only if you’re not staying with pets. I also liked that this location didn’t charge for parking."
A verified traveler stayed at Drury Inn & Suites St Joseph
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