Explore top 2026 4 Star Hotels in Southeastern Indiana

Name: The Grady
Price range: $223 total

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Top Southeastern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

$144 nightly

$170 total

Oct 27 - Oct 28

Total with taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9/10 Wonderful! (4,362 reviews)

"Bed was great. Elevators were dedicated to others and we peons had to wait 20-30 minutes to use them."

Reviewed on Oct 11, 2026

Omni Louisville Hotel

400 S. 2nd Street Louisville KY

$254 nightly

$299 total

Oct 30 - Oct 31

Total with taxes and fees

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.4/10 Exceptional! (2,178 reviews)

"Beautiful property, great location"

Reviewed on Oct 11, 2026

The Brown Hotel

335 W Broadway Louisville KY

Fully refundableReserve now, pay when you stay

$156 nightly

$183 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

9.4/10 Exceptional! (1,364 reviews)

"Everything was amazing! Except…that might be the worst mattress I’ve ever slept on, with basic, uncomfortable pillows. My back hurt for an entire day. Everything else, incredible. The food, the staff, the architecture…wow. Just get new beds. I will probably come back to stay the night, but I will ..."

Reviewed on Oct 11, 2026

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

$147 nightly

$173 total

Oct 29 - Oct 30

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...

9/10 Wonderful! (1,380 reviews)

"Leading up to the trip communication was amazing. I thought the staff at the desk was pleasant & helpful. And the hotel is beautiful & clean. Our only complaint was the shuttle. We followed the information provided for using it & were told upon arrival at the airport that we would need to wait as ..."

Reviewed on Oct 11, 2026

Hyatt Regency Louisville

320 West Jefferson Street Louisville KY

$161 nightly

$189 total

Oct 29 - Oct 30

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

Louisville Marriott Downtown

280 West Jefferson Street Louisville KY

$223 nightly

$262 total

Nov 7 - Nov 8

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$156 nightly

$184 total

Nov 8 - Nov 9

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.4/10 Exceptional! (1,004 reviews)

"Great service. We had an emergency and staff were excellent handling it."

Reviewed on Oct 11, 2026

Hotel Genevieve part of JdV by Hyatt

730 E Market St Louisville KY

Fully refundableReserve now, pay when you stay

$144 nightly

$169 total

Nov 8 - Nov 9

Total with taxes and fees

This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.

Hotel Distil, Autograph Collection

101 West Main Street Louisville KY

$237 nightly

$279 total

Oct 29 - Oct 30

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

9.6/10 Exceptional! (509 reviews)

"The room exceeded expectations! All of the restaurants had exceptional food! Beautiful hotel, great location, and very friendly staff!"

Reviewed on Oct 11, 2026

The Grady

601 W Main St Louisville KY

$190 nightly

$223 total

Oct 18 - Oct 19

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Southeastern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southeastern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southeastern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southeastern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.