Explore top 2026 4 Star Hotels in Southeastern Indiana

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Top Southeastern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $168 total per night from May 24 to May 25
$168 total
May 24 - May 25
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9/10 Wonderful! (4,205 reviews)
It was very good, I enjoyed the room service

Reviewed on May 2, 2026

Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $293 total per night from May 7 to May 8
$293 total
May 7 - May 8
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (1,866 reviews)
Front staff were absolutely amazing.

Reviewed on May 2, 2026

Opens in a new windowOmni Louisville Hotel
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $182 total per night from May 27 to May 28
$182 total
May 27 - May 28
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.4/10 Exceptional! (1,184 reviews)
Clean room, attentive staff

Reviewed on May 1, 2026

Opens in a new windowThe Brown Hotel
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
$122 nightly
The price is $144 total per night from May 25 to May 26
$144 total
May 25 - May 26
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
9/10 Wonderful! (1,207 reviews)
Very nice and clean room. Friendly staff!

Reviewed on May 2, 2026

Opens in a new windowEmbassy Suites Louisville Downtown
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $201 total per night from May 22 to May 23
$201 total
May 22 - May 23
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,003 reviews)
The television wasn’t working and even though I called twice it was not repaired until the last night of our 3 night stay.

Reviewed on May 1, 2026

Opens in a new windowLouisville Marriott Downtown
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $144 total per night from May 23 to May 24
$144 total
May 23 - May 24
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.8/10 Excellent! (1,002 reviews)
Staff incredibly helpful with late check in. Will always be first choice in Louisville

Reviewed on Apr 30, 2026

Opens in a new windowHyatt Regency Louisville
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

4 out of 5
730 E Market St Louisville KY
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from May 10 to May 11
$159 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.
9.2/10 Wonderful! (1,084 reviews)
Exceptional hotel!

Reviewed on Apr 28, 2026

Opens in a new windowHotel Genevieve part of JdV by Hyatt
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4 out of 5
101 West Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $206 total per night from May 25 to May 26
$206 total
May 25 - May 26
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.6/10 Exceptional! (465 reviews)
Love staying here when we are in Louisville.

Reviewed on May 2, 2026

Opens in a new windowHotel Distil, Autograph Collection
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $184 total per night from May 25 to May 26
$184 total
May 25 - May 26
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.4/10 Exceptional! (1,002 reviews)
Everything in gift shop dusty. Receptionist putting her make up on at front desk. Valet staff friendly and helpful

Reviewed on Apr 29, 2026

Opens in a new window21c Museum Hotel Louisville
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $209 total per night from May 24 to May 25
$209 total
May 24 - May 25
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
9.4/10 Exceptional! (1,001 reviews)
We were on street side of building and street was noisy all nite. Front desk staff was very friendly and helpful

Reviewed on Apr 27, 2026

Opens in a new windowThe Grady
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4 Star Hotels Southeastern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southeastern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southeastern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southeastern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Southeastern Indiana hotel reviews by fellow wanderers

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