Explore top 2026 4 Star Hotels in Southeastern Indiana

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Top Southeastern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$133 nightly
The price is $157 total per night from Dec 15 to Dec 16
$157 total
Dec 15 - Dec 16
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.8/10 Excellent! (3,828 reviews)
Spacious

Reviewed on Dec 7, 2025

Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $197 total per night from Jan 1 to Jan 2
$197 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (1,713 reviews)
Everything was great - nice hotel, clean room and friendly service. Hard to go wrong when choosing Omni.

Reviewed on Dec 8, 2025

Opens in a new windowOmni Louisville Hotel
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $131 total per night from Dec 28 to Dec 29
$131 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
8.8/10 Excellent! (1,096 reviews)
I have been on a 10-year academic journey, studying, and needed a recharge. This was the perfect staycation. Everything was really very nice! Thank you.

Reviewed on Dec 4, 2025

Opens in a new windowEmbassy Suites Louisville Downtown
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $198 total per night from Dec 18 to Dec 19
$198 total
Dec 18 - Dec 19
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.2/10 Wonderful! (1,145 reviews)
Very nice hotel and good location walkable to 4th street live

Reviewed on Dec 7, 2025

Opens in a new windowThe Brown Hotel
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

4 out of 5
730 E Market St Louisville KY
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $149 total per night from Dec 14 to Dec 15
$149 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features 2 restaurants and 3 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.
9/10 Wonderful! (1,015 reviews)
Nice hotel!

Reviewed on Dec 8, 2025

Opens in a new windowHotel Genevieve part of JdV by Hyatt
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $169 total per night from Jan 1 to Jan 2
$169 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,000 reviews)
Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!

Reviewed on Dec 9, 2025

Opens in a new window21c Museum Hotel Louisville
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $135 total per night from Dec 14 to Dec 15
$135 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.6/10 Excellent! (1,002 reviews)
Room was perfect! Staff members were friendly. Amenities were well kept! We would stay again.

Reviewed on Nov 30, 2025

Opens in a new windowHyatt Regency Louisville
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $189 total per night from Dec 17 to Dec 18
$189 total
Dec 17 - Dec 18
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
9.4/10 Exceptional! (1,006 reviews)
Room desk had some kind of white grease or lotion all over it. The mirror in the bathroom was covered in dusk. There were only two bath towels for a room of 4. For $300+ a night it really offered nothing except Instagram pics

Reviewed on Dec 8, 2025

Opens in a new windowThe Grady
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $201 total per night from Dec 19 to Dec 20
$201 total
Dec 19 - Dec 20
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,001 reviews)
Very nice hotel. Great stay!

Reviewed on Dec 6, 2025

Opens in a new windowLouisville Marriott Downtown
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4 out of 5
101 West Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $206 total per night from Dec 25 to Dec 26
$206 total
Dec 25 - Dec 26
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (427 reviews)
Very accommodating for our little pup. Plus the bed was super comfy.

Reviewed on Nov 30, 2025

Opens in a new windowHotel Distil, Autograph Collection
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4 Star Hotels Southeastern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southeastern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southeastern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southeastern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Southeastern Indiana hotel reviews by fellow wanderers

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