Explore top 2026 4 Star Hotels in Northeast Missouri

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Top Northeast Missouri 4 Star hotels

21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $162 total per night from Apr 5 to Apr 6
$162 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,669 reviews)
Staff was very friendly and helpful. Loved receiving the tour of the current art show! A must in my opinion. Loved Idol Wolf and Good Press for breakfast or happy hour. Wish they offered more than massage services in the spa though. If you prefer getting around town on foot or public transportation, ...

Reviewed on Mar 17, 2026

Opens in a new window21C Museum Hotel St Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $149 total per night from Mar 29 to Mar 30
$149 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
8.4/10 Very Good! (1,068 reviews)
Clean room

Reviewed on Mar 17, 2026

Opens in a new windowRenaissance St. Louis Airport Hotel
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Apr 5 to Apr 6
$111 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9/10 Wonderful! (1,494 reviews)
Room was okay, definitely out dated. There was hair inside the bathtub wall. Possible from previous occupant.

Reviewed on Mar 15, 2026

Opens in a new windowRiver City Casino & Hotel
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $158 total per night from Apr 5 to Apr 6
$158 total
Apr 5 - Apr 6
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
8.6/10 Excellent! (1,006 reviews)
🙂

Reviewed on Mar 16, 2026

Opens in a new windowThe Westin St. Louis
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
$149 nightly
The price is $177 total per night from Apr 5 to Apr 6
$177 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,126 reviews)
Room was amazing, only downfall was the fridge in the room didn’t work

Reviewed on Mar 17, 2026

Opens in a new windowLive by Loews - St.Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $215 total per night from Apr 5 to Apr 6
$215 total
Apr 5 - Apr 6
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside ...
8.4/10 Very Good! (1,013 reviews)
The stay was fine but the pool and jacuzzi area closing at 6pm on Saturday night is less than ideal....is this the no fun zone?

Reviewed on Mar 16, 2026

Opens in a new windowAmeristar Casino Resort and Spa
DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
4550 Forest Park Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $146 total per night from Apr 5 to Apr 6
$146 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.2/10 Very Good! (1,002 reviews)
Location is good for access to Barnes Hospital and Center for Advanced Medicine. There is an adjacent Applebee's restaurant. The breakfast is not a great value, overpriced for fare that is free at most 3 star hotels. Parking costs about $16 per night. Room was adequate but not up to Hilton standards. ...

Reviewed on Mar 15, 2026

Opens in a new windowDoubleTree by Hilton St. Louis Forest Park
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $143 total per night from Mar 29 to Mar 30
$143 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.8/10 Excellent! (1,263 reviews)
The room was about the only good thing about this hotel. The parking was a nightmare. Ridiculously expensive. The food wasnt that good and it was very over priced. They are short staffed very badly in the restaurant so wait times were so long. The condition of the hotel was pretty trashy. It just ...

Reviewed on Mar 14, 2026

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
$184 nightly
The price is $217 total per night from Mar 29 to Mar 30
$217 total
Mar 29 - Mar 30
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,004 reviews)
The property was well maintained, and everybody was very helpful polite the day was phenomenal. We couldn’t ask for anything else. It was great.

Reviewed on Mar 17, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark

4 out of 5
1 S Broadway St. Louis MO
$155 nightly
The price is $184 total per night from Apr 5 to Apr 6
$184 total
Apr 5 - Apr 6
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an indoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
7.6/10 Good! (1,084 reviews)
At check in w were told the room we reserved was not available. The room they replaced it with was used and had trash inside. Was then made to wait another hour for a different room to be ready

Reviewed on Mar 16, 2026

Opens in a new windowHilton St. Louis at the Ballpark
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4 Star Hotels Northeast Missouri

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Northeast Missouri 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Northeast Missouri will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Northeast Missouri, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Northeast Missouri hotel reviews by fellow wanderers

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