Vacation Homes in Southeast Missouri, MO
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Top Vacation Homes in Southeast Missouri

Unique cabins in the woods<br>Not friendly for Street Bikes.

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

Unbeatable convenience in amazing Eminence!

Cozy Three bedroom home in Central Farmington

Family-Friendly 3BR/2BA Van Buren Home w/ Fire Pit & Starlink WiFi!

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

CURRENT RIVER FRONT CABIN … 4 bed room on the waters edge

Clifford's Country Cottage

River Time Cottage Get Away! 1/2 Mile from Current River!

Private Hot Tub + Fire Pit | 4BR/2Bth Ranch | 10 Min to Historic Ste. Genevieve by Timber Oaks Vacation Rentals

Quaint, Beautiful Home next to SEMO and Hospital
Top hotels in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center
Find the Best Vacation Homes in Southeast Missouri
Why book a vacation home in Southeast Missouri?
Vacation homes in Southeast Missouri make for a different travel experience. Your holiday home will allow you to feel at home during your visit. You’ll usually have more space, more privacy, and extra amenities not typically included with hotel stays.
How much is a vacation home in Southeast Missouri?
Private Southeast Missouri rental homes range between $63 - $406 per night. Prices change based on seasonal demand, travel dates, property location, capacity, amenities, etc.
What are the cancellation and flexibility options on Travelocity?
To cancel your vacation home, you must reach out to the individual property manager. Their contact details are available in your itinerary. For more information, head over to our customer service portal. Use the ‘free cancellation’ or ‘reserve now, pay later’ filters to find the most flexible options for your bookings.
What amenities should I look out for in a vacation home?
There are some exciting amenities available in Southeast Missouri vacation home rentals. You might look for Southeast Missouri rental houses with a private pool or free Wi-Fi. Some popular amenities also include a private hot tub, air-conditioning, laundry facilities, and a games room.
Vacation rentals in Southeast Missouri offer other accommodations that may interest you. Some have resort-like amenities such as a fitness center, bar/lounge, or swimming pool.
When is the best time to rent a vacation home in Southeast Missouri?
You’ll typically get cheaper rates when staying during the off-season, . Prices are usually at their lowest for stays in . are the most popular months to visit.
Why book a vacation home with Travelocity?
Travel smart with Travelocity. Search over 1 million properties worldwide and access an incredible selection of holiday homes in Southeast Missouri. Our members save 10% or more on select hotels, and if you find a lower price, we’ll match it with our Price Match Guarantee. Get started finding Southeast Missouri hotels and vacation homes that best suit your stay. We also have deals for flights, and Southeast Missouri car rentals. You’ll save even more when you bundle your items into a Southeast Missouri vacation package!
How many vacation homes are available to book in Southeast Missouri?
There are 207 rental homes in Southeast Missouri. Enter your travel dates to check availability.
How do I find the best price for a vacation home in Southeast Missouri?
Private vacation homes vary in price, and we’ll help you get the best deal possible. Use the map feature to compare rental house prices in different neighborhoods. Also, try adjusting your dates to compare nightly rates within a similar timeframe.
Southeast Missouri Vacation Homes essential information
Accommodation | 207 Vacation Homes |
|---|---|
Lowest Price | $63 |
Highest Price | $406 |
Popular accommodation | Unique cabins in the woods Not friendly for Street Bikes. , 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau, Unbeatable convenience in amazing Eminence!, Cozy Three bedroom home in Central Farmington, Family-Friendly 3BR/2BA Van Buren Home w/ Fire Pit & Starlink WiFi!, Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy, CURRENT RIVER FRONT CABIN … 4 bed room on the waters edge, Clifford's Country Cottage, River Time Cottage Get Away! 1/2 Mile from Current River!, Private Hot Tub + Fire Pit | 4BR/2Bth Ranch | 10 Min to Historic Ste. Genevieve by Timber Oaks Vacation Rentals, Quaint, Beautiful Home next to SEMO and Hospital, Charming 2-bedroom house with AC, WiFi in serene Van Buren |
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