Book Hotels in South Carolina Midlands, SC

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Top South Carolina Midlands hotels

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Fully refundable
$80 nightly
The price is $89 total per night from Sep 7 to Sep 8
$89 total
Sep 7 - Sep 8
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free ...
"It was comfortable and clean We enjoyed our stay"

Reviewed on Aug 29, 2026

Opens in a new windowPark Inn by Radisson Florence, SC
Courtyard by Marriott Columbia Downtown at USC

Courtyard by Marriott Columbia Downtown at USC

3 out of 5
630 Assembly St Columbia SC
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $132 total per night from Sep 7 to Sep 8
$132 total
Sep 7 - Sep 8
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. There's ...
"I didn’t like this hotel and will never come back here. The bathroom is so, so tiny. I don’t understand why the footprint of the bathroom was sacrificed for a wardrobe, a fridge, and a microwave. Usually, these amenities are along the room's corridor so they don’t take away from the bathroom footprint. ..."

Reviewed on Aug 29, 2026

Opens in a new windowCourtyard by Marriott Columbia Downtown at USC
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $98 total per night from Sep 28 to Sep 29
$98 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Clean room"

Reviewed on Aug 29, 2026

Opens in a new windowQuality Inn & Suites Florence Civic Center
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

3 out of 5
7333 Garners Ferry Rd Columbia SC
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $114 total per night from Aug 31 to Sep 1
$114 total
Aug 31 - Sep 1
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
"Excellent!"

Reviewed on Aug 29, 2026

Opens in a new windowLa Quinta Inn by Wyndham Columbia SE / Fort Jackson
Sleep Inn Columbia

Sleep Inn Columbia

2.5 out of 5
1901 Rockland Rd Columbia SC
Fully refundable
$84 nightly
The price is $91 total per night from Sep 20 to Sep 21
$91 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...
"Smelled like an older hotel not unexpectedly so"

Reviewed on Aug 29, 2026

Opens in a new windowSleep Inn Columbia
Wyndham Garden Columbia/Ft. Jackson

Wyndham Garden Columbia/Ft. Jackson

2.5 out of 5
1539 Horseshoe Dr Columbia SC
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $87 total per night from Sep 6 to Sep 7
$87 total
Sep 6 - Sep 7
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Business travelers can take advantage of the free WiFi in public areas. Guests will appreciate freebies ...
"Unfortunately, our stay was very disappointing. The room was not clean or properly maintained when we arrived. There was makeup on the pillows, and we even found a dirty thong behind the headboard, which was extremely concerning and unacceptable. The bathroom was also dirty, and the soap and shampoo ..."

Reviewed on Aug 29, 2026

Opens in a new windowWyndham Garden Columbia/Ft. Jackson
Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison

3 out of 5
434 Columbiana Dr Columbia SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $99 total per night from Sep 10 to Sep 11
$99 total
Sep 10 - Sep 11
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowHilton Garden Inn Columbia/Harbison
Tru By Hilton Columbia Downtown

Tru By Hilton Columbia Downtown

2.5 out of 5
400 Gervais Street Columbia SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $109 total per night from Sep 6 to Sep 7
$109 total
Sep 6 - Sep 7
Total with taxes and fees
A gym is featured at this hotel, along with self parking. Guests will appreciate free perks like daily breakfast and WiFi in public areas. Staff at the 24-hour ...
Opens in a new windowTru By Hilton Columbia Downtown
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $71 total per night from Aug 31 to Sep 1
$71 total
Aug 31 - Sep 1
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Opens in a new windowHoward Johnson by Wyndham Florence
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap South Carolina Midlands hotels

Econo Lodge Rock Hill Northeast

Econo Lodge Rock Hill Northeast

914 Riverview Rd Rock Hill SC
$48 nightly
The price is $55 total per night from Sep 19 to Sep 20
$55 total
Sep 19 - Sep 20
Total with taxes and fees
6.2/10 (939 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent South Carolina Midlands hotel reviews by fellow wanderers

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

4 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Clean room"
A verified traveler stayed at Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center

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