Book Hotels in South Carolina Midlands, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top South Carolina Midlands hotels

Tru By Hilton Columbia Downtown

Tru By Hilton Columbia Downtown

2.5 out of 5
400 Gervais Street, Building 2, Columbia, SC
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $115 total per night from Aug 24 to Aug 25
$115 total
Aug 24 - Aug 25
Total includes taxes and fees
A gym is featured at this hotel, along with self parking. Guests will appreciate free perks like daily breakfast and WiFi in public areas. Staff at the 24-hour ...
"They offer a.full breakfast the staff is so friendly. There was not a pool on site but we found other things to do."

Reviewed on Jul 20, 2025

Tru By Hilton Columbia Downtown
Comfort Inn & Suites

Comfort Inn & Suites

2.5 out of 5
527 Woody Jones Blvd, Florence, SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $123 total per night from Aug 10 to Aug 11
$123 total
Aug 10 - Aug 11
Total includes taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
"Everything was great. Nice and quiet and friendly staff."

Reviewed on Jul 21, 2025

Comfort Inn & Suites
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road, Florence, SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Aug 17 to Aug 18
$105 total
Aug 17 - Aug 18
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Business travelers can take advantage of the business center. Enjoy ...
A Pleasant Surprise After Last-Minute Changes
"We ended up booking this hotel at the last minute due to some security issues at our original property, and I’m honestly glad we did. From the moment we walked in, it was clear this place takes cleanliness seriously – everything was spotless. You can tell the hotel is on the newer side, but what ..."

Reviewed on Jul 23, 2025

Park Inn by Radisson Florence, SC
Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison

3 out of 5
434 Columbiana Dr, Columbia, SC
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $104 total per night from Aug 17 to Aug 18
$104 total
Aug 17 - Aug 18
Total includes taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"This place was excellent I loved the view and how everything was around the area."

Reviewed on Jul 23, 2025

Hilton Garden Inn Columbia/Harbison
Clarion Pointe Near University

Clarion Pointe Near University

2.5 out of 5
1106 N. Anderson Road, Rock Hill, SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $84 total per night from Aug 10 to Aug 11
$84 total
Aug 10 - Aug 11
Total includes taxes and fees
A gym, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi in public ...
Nice hotel Nice price
"Only stayed 1 night but it was great and would definitely stay again. Super quiet! Good location. Bed was comfortable and bathroom was a nice size. Felt secure"

Reviewed on Jul 23, 2025

Clarion Pointe Near University
 La Quinta Inn by Wyndham Columbia NE/Fort Jackson

La Quinta Inn by Wyndham Columbia NE/Fort Jackson

3 out of 5
1538 Horseshoe Drive, Columbia, SC
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $92 total per night from Aug 3 to Aug 4
$92 total
Aug 3 - Aug 4
Total includes taxes and fees
This smoke-free hotel includes 20 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Breakfast"

Reviewed on Jul 23, 2025

La Quinta Inn by Wyndham Columbia NE/Fort Jackson
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Jul 27 to Jul 28
$79 total
Jul 27 - Jul 28
Total includes taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Nice and close to the interstate. Very nice comfortable and clean room. The price was budget friendly"

Reviewed on Jul 22, 2025

Howard Johnson by Wyndham Florence
Wyndham Garden Columbia/Ft. Jackson

Wyndham Garden Columbia/Ft. Jackson

2.5 out of 5
1539 Horseshoe Dr, Columbia, SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $94 total per night from Aug 3 to Aug 4
$94 total
Aug 3 - Aug 4
Total includes taxes and fees
This hotel features a gym and a seasonal outdoor pool. Business travelers can take advantage of the free WiFi in public areas. Guests will appreciate freebies ...
"We stayed one night. Friendly staff, clean room. Only thing is, you can hear all the other rooms and people in the main area during the night."

Reviewed on Jul 22, 2025

Wyndham Garden Columbia/Ft. Jackson
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

3 out of 5
7333 Garners Ferry Rd, Columbia, SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $94 total per night from Jul 27 to Jul 28
$94 total
Jul 27 - Jul 28
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 24-hour ...
"Hospitality was Great room was good and clean everything was perfect"

Reviewed on Jul 16, 2025

La Quinta Inn by Wyndham Columbia SE / Fort Jackson
Don't see what you're looking for?
See all available properties in South Carolina Midlands
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap South Carolina Midlands hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent South Carolina Midlands hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity

Explore More Ways to Travel with Travelocity