South Carolina Midlands , SC Pet Friendly Hotels
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Top South Carolina Midlands Pet Friendly Hotels

Hampton Inn Columbia I-26/Harbison Blvd.
101 Woodcross Dr Columbia SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $118 total per night from May 14 to May 15
$118 total
May 14 - May 15
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
9.2/10 Wonderful! (1,000 reviews)
Great
Reviewed on Apr 20, 2026

Quality Inn & Suites Florence Civic Center
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from May 10 to May 11
$106 total
May 10 - May 11
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
8.6/10 Excellent! (116 reviews)
Very nice and clean friendly staff easy to get to from I95
Reviewed on Apr 30, 2026

Holiday Inn Santee by IHG
139 Bradford Blvd Santee SC
Fully refundable
$122 nightly
The price is $135 total per night from May 19 to May 20
$135 total
May 19 - May 20
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8.2/10 Very Good! (1,001 reviews)
Have to pay
Reviewed on Apr 30, 2026

La Quinta Inn by Wyndham Columbia SE / Fort Jackson
7333 Garners Ferry Rd Columbia SC
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $93 total per night from May 24 to May 25
$93 total
May 24 - May 25
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
8/10 Very Good! (999 reviews)
Staff was accommodating and very helpful. The room was clean. Overall it was a nice place to stay.
Reviewed on Apr 28, 2026

La Quinta Inn & Suites by Wyndham Florence
2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $109 total per night from May 3 to May 4
$109 total
May 3 - May 4
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
7.8/10 Good! (1,604 reviews)
Every thing was great. Easy to get on and off 95
Reviewed on Apr 29, 2026

Spark by Hilton Orangeburg
731 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $115 total per night from May 3 to May 4
$115 total
May 3 - May 4
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
7.8/10 Good! (1,000 reviews)
Had ants every where!
Reviewed on Apr 25, 2026

Best Western Inn
1808 W Lucas Street Florence SC
$99 nightly
The price is $111 total per night from May 3 to May 4
$111 total
May 3 - May 4
Total with taxes and fees
A seasonal outdoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public ...
7.8/10 Good! (1,000 reviews)
Staff was friendly. Rooms are pet friendly and relatively clean. Great water pressure In shower. Really great breakfast included.
Reviewed on Apr 19, 2026

Red Roof Inn Florence - Civic Center
2690 David H McLeod Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $68 total per night from May 4 to May 5
$68 total
May 4 - May 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
6.8/10 (1,000 reviews)
It does the job. Clean bed and bathroom.
Reviewed on Apr 10, 2026
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Pet Friendly Hotel in South Carolina Midlands
South Carolina Midlands hotels essential information
Accommodation | 3,282 hotels |
|---|---|
Lowest Price | $68 |
Highest Price | $135 |
Popular hotels | La Quinta Inn & Suites by Wyndham Florence, La Quinta Inn by Wyndham Columbia SE / Fort Jackson, Hampton Inn Columbia I-26/Harbison Blvd., Spark by Hilton Orangeburg, Quality Inn & Suites Florence Civic Center, Holiday Inn Santee by IHG, Red Roof Inn Florence - Civic Center, Best Western Inn |
Recent South Carolina Midlands hotel reviews by fellow wanderers

Hyatt Place Columbia/Downtown/The Vista
3 out of 5
Posted 21 hours ago
Travelocity Verified Review
"Shampoo and Soap were empty in the shower and the lotion on the countertop was already used. Pretty gross.
Breakfast was subpar compared to most but overall wasn’t bad for a quick pit stop on a road trip.
Wouldn’t return if staying more than 1 night. "
A verified traveler stayed at Hyatt Place Columbia/Downtown/The Vista
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