South Carolina Midlands , SC Pet Friendly Hotels

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Top South Carolina Midlands Pet Friendly Hotels

Hampton Inn Columbia I-26/Harbison Blvd.

Hampton Inn Columbia I-26/Harbison Blvd.

101 Woodcross Dr Columbia SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $109 total per night from Jan 18 to Jan 19
$109 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
9/10 Wonderful! (1,004 reviews)
The room was spotless and the desk clerk was very friendly and explained everything great

Reviewed on Jan 1, 2026

Opens in a new windowHampton Inn Columbia I-26/Harbison Blvd.
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

139 Bradford Blvd Santee SC
Fully refundable
$118 nightly
The price is $131 total per night from Jan 11 to Jan 12
$131 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8/10 Very Good! (981 reviews)
Staff in the restaurant Dinner shift were excellent.

Reviewed on Jan 2, 2026

Opens in a new windowHoliday Inn Santee by IHG
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Jan 12 to Jan 13
$105 total
Jan 12 - Jan 13
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
7.8/10 Good! (1,683 reviews)
Yes

Reviewed on Jan 2, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $88 total per night from Jan 25 to Jan 26
$88 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
7.8/10 Good! (1,258 reviews)
Everything was perfect

Reviewed on Jan 5, 2026

Opens in a new windowQuality Inn & Suites Florence Civic Center
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

7333 Garners Ferry Rd Columbia SC
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $75 total per night from Jan 11 to Jan 12
$75 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 24-hour ...
7.6/10 Good! (1,012 reviews)
The staff was very helpful timely check in. Room was clean. The slide lock on room door was totally missing. The elevator ceiling tile was missing giving access to lighting overhead. Vulgar language was inscribed on wall of elevator.

Reviewed on Jan 1, 2026

Opens in a new windowLa Quinta Inn by Wyndham Columbia SE / Fort Jackson
Spark by Hilton Orangeburg

Spark by Hilton Orangeburg

731 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $97 total per night from Jan 11 to Jan 12
$97 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
7.6/10 Good! (1,004 reviews)
The recent renovations were really nice. My room, along with the other parts of the hotel, was very clean and there was no hesitation to get assistance from the staff when needed. Among the staff, Tomeeka and the Assistant Manager Astria were exceptional! I’m excited to return.

Reviewed on Jan 2, 2026

Opens in a new windowSpark by Hilton Orangeburg
Best Western Inn

Best Western Inn

1808 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Jan 8 to Jan 9
$100 total
Jan 8 - Jan 9
Total with taxes and fees
A seasonal outdoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public ...
7.6/10 Good! (1,008 reviews)
Clean rooms. Great staff. Very friendly and helpful.

Reviewed on Jan 3, 2026

Opens in a new windowBest Western Inn
Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2690 David H McLeod Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $63 total per night from Jan 11 to Jan 12
$63 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
6.6/10 (1,001 reviews)
The A/C was a bit difficult to handle. The buttons to change the temperature caused the machine to change between modes settings instead. Not to mention, the room could use some renovating. There was patches of paint just hanging from the ceiling.

Reviewed on Dec 29, 2025

Opens in a new windowRed Roof Inn Florence - Civic Center
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Carolina Midlands hotels essential information

Accommodation
3,114 hotels
Lowest Price
$63
Highest Price
$131
Popular hotels
La Quinta Inn & Suites by Wyndham Florence, La Quinta Inn by Wyndham Columbia SE / Fort Jackson, Hampton Inn Columbia I-26/Harbison Blvd., Spark by Hilton Orangeburg, Quality Inn & Suites Florence Civic Center, Holiday Inn Santee by IHG, Red Roof Inn Florence - Civic Center, Best Western Inn

Recent South Carolina Midlands hotel reviews by fellow wanderers

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