South Carolina Midlands , SC Pet Friendly Hotels

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Top South Carolina Midlands Pet Friendly Hotels

Hampton Inn Columbia I-26/Harbison Blvd.

Hampton Inn Columbia I-26/Harbison Blvd.

101 Woodcross Dr Columbia SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $118 total per night from May 14 to May 15
$118 total
May 14 - May 15
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
9.2/10 Wonderful! (1,000 reviews)
Great

Reviewed on Apr 20, 2026

Opens in a new windowHampton Inn Columbia I-26/Harbison Blvd.
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from May 10 to May 11
$106 total
May 10 - May 11
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
8.6/10 Excellent! (116 reviews)
Very nice and clean friendly staff easy to get to from I95

Reviewed on Apr 30, 2026

Opens in a new windowQuality Inn & Suites Florence Civic Center
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

139 Bradford Blvd Santee SC
Fully refundable
$122 nightly
The price is $135 total per night from May 19 to May 20
$135 total
May 19 - May 20
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8.2/10 Very Good! (1,001 reviews)
Have to pay

Reviewed on Apr 30, 2026

Opens in a new windowHoliday Inn Santee by IHG
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

7333 Garners Ferry Rd Columbia SC
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $93 total per night from May 24 to May 25
$93 total
May 24 - May 25
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
8/10 Very Good! (999 reviews)
Staff was accommodating and very helpful. The room was clean. Overall it was a nice place to stay.

Reviewed on Apr 28, 2026

Opens in a new windowLa Quinta Inn by Wyndham Columbia SE / Fort Jackson
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $109 total per night from May 3 to May 4
$109 total
May 3 - May 4
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
7.8/10 Good! (1,604 reviews)
Every thing was great. Easy to get on and off 95

Reviewed on Apr 29, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Florence
Spark by Hilton Orangeburg

Spark by Hilton Orangeburg

731 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $115 total per night from May 3 to May 4
$115 total
May 3 - May 4
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
7.8/10 Good! (1,000 reviews)
Had ants every where!

Reviewed on Apr 25, 2026

Opens in a new windowSpark by Hilton Orangeburg
Best Western Inn

Best Western Inn

1808 W Lucas Street Florence SC
$99 nightly
The price is $111 total per night from May 3 to May 4
$111 total
May 3 - May 4
Total with taxes and fees
A seasonal outdoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public ...
7.8/10 Good! (1,000 reviews)
Staff was friendly. Rooms are pet friendly and relatively clean. Great water pressure In shower. Really great breakfast included.

Reviewed on Apr 19, 2026

Opens in a new windowBest Western Inn
Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2690 David H McLeod Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $68 total per night from May 4 to May 5
$68 total
May 4 - May 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
6.8/10 (1,000 reviews)
It does the job. Clean bed and bathroom.

Reviewed on Apr 10, 2026

Opens in a new windowRed Roof Inn Florence - Civic Center
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Carolina Midlands hotels essential information

Accommodation
3,282 hotels
Lowest Price
$68
Highest Price
$135
Popular hotels
La Quinta Inn & Suites by Wyndham Florence, La Quinta Inn by Wyndham Columbia SE / Fort Jackson, Hampton Inn Columbia I-26/Harbison Blvd., Spark by Hilton Orangeburg, Quality Inn & Suites Florence Civic Center, Holiday Inn Santee by IHG, Red Roof Inn Florence - Civic Center, Best Western Inn

Recent South Carolina Midlands hotel reviews by fellow wanderers

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