South Carolina Midlands , SC Pet Friendly Hotels

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Top South Carolina Midlands Pet Friendly Hotels

Hampton Inn Columbia I-26/Harbison Blvd.

Hampton Inn Columbia I-26/Harbison Blvd.

101 Woodcross Dr Columbia SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $109 total per night from Jan 25 to Jan 26
$109 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
9/10 Wonderful! (1,000 reviews)
I was totally impressed buy the service I received from Alexa. Once we checked in the texted us to make sure everything thing was ok and asked if there was anything she could do to improve our experience The room was clean. The bed was so comfortable. I highly recommend this location. The Hampton ...

Reviewed on Jan 9, 2026

Opens in a new windowHampton Inn Columbia I-26/Harbison Blvd.
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

139 Bradford Blvd Santee SC
Fully refundable
$112 nightly
The price is $124 total per night from Feb 8 to Feb 9
$124 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8/10 Very Good! (987 reviews)
Staff in the restaurant Dinner shift were excellent.

Reviewed on Jan 2, 2026

Opens in a new windowHoliday Inn Santee by IHG
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Jan 25 to Jan 26
$106 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
7.8/10 Good! (1,679 reviews)
Extremely clean room very friendly staff breakfast had a great variety

Reviewed on Jan 13, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $94 total per night from Feb 2 to Feb 3
$94 total
Feb 2 - Feb 3
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
7.8/10 Good! (1,251 reviews)
Everything was perfect

Reviewed on Jan 5, 2026

Opens in a new windowQuality Inn & Suites Florence Civic Center
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

7333 Garners Ferry Rd Columbia SC
$68 nightly
The price is $76 total per night from Jan 25 to Jan 26
$76 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
7.6/10 Good! (1,010 reviews)
Rooms updated excellent appearance. Room ac had some extra vibration sound to deal with and bat vent fan a little noisy needed to be tightened up. Food good coffee and hot water not enough closer to warm. Arrival erson was more friendly and pleasant compared to check out person. Overall very impressed ...

Reviewed on Jan 13, 2026

Opens in a new windowLa Quinta Inn by Wyndham Columbia SE / Fort Jackson
Spark by Hilton Orangeburg

Spark by Hilton Orangeburg

731 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $97 total per night from Feb 1 to Feb 2
$97 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
7.6/10 Good! (1,000 reviews)
Clean rooms, good location, nice and polite staff

Reviewed on Jan 11, 2026

Opens in a new windowSpark by Hilton Orangeburg
Best Western Inn

Best Western Inn

1808 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Jan 18 to Jan 19
$100 total
Jan 18 - Jan 19
Total with taxes and fees
A seasonal outdoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public ...
7.6/10 Good! (1,000 reviews)
It was a decent room and the breakfast was good

Reviewed on Jan 5, 2026

Opens in a new windowBest Western Inn
Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2690 David H McLeod Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $63 total per night from Jan 20 to Jan 21
$63 total
Jan 20 - Jan 21
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
6.6/10 (1,000 reviews)
Room was good. No microwave tho. Staff was very courteous and helpful

Reviewed on Jan 9, 2026

Opens in a new windowRed Roof Inn Florence - Civic Center
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Carolina Midlands hotels essential information

Accommodation
3,136 hotels
Lowest Price
$63
Highest Price
$124
Popular hotels
La Quinta Inn & Suites by Wyndham Florence, La Quinta Inn by Wyndham Columbia SE / Fort Jackson, Hampton Inn Columbia I-26/Harbison Blvd., Spark by Hilton Orangeburg, Quality Inn & Suites Florence Civic Center, Holiday Inn Santee by IHG, Red Roof Inn Florence - Civic Center, Best Western Inn

Recent South Carolina Midlands hotel reviews by fellow wanderers

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