South Carolina Midlands , SC Pet Friendly Hotels
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Top South Carolina Midlands Pet Friendly Hotels

Hampton Inn Columbia I-26/Harbison Blvd.
101 Woodcross Dr Columbia SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $109 total per night from Jan 18 to Jan 19
$109 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
9/10 Wonderful! (1,004 reviews)
The room was spotless and the desk clerk was very friendly and explained everything great
Reviewed on Jan 1, 2026

Holiday Inn Santee by IHG
139 Bradford Blvd Santee SC
Fully refundable
$118 nightly
The price is $131 total per night from Jan 11 to Jan 12
$131 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8/10 Very Good! (981 reviews)
Staff in the restaurant Dinner shift were excellent.
Reviewed on Jan 2, 2026

La Quinta Inn & Suites by Wyndham Florence
2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Jan 12 to Jan 13
$105 total
Jan 12 - Jan 13
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
7.8/10 Good! (1,683 reviews)
Yes
Reviewed on Jan 2, 2026

Quality Inn & Suites Florence Civic Center
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $88 total per night from Jan 25 to Jan 26
$88 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
7.8/10 Good! (1,258 reviews)
Everything was perfect
Reviewed on Jan 5, 2026

La Quinta Inn by Wyndham Columbia SE / Fort Jackson
7333 Garners Ferry Rd Columbia SC
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $75 total per night from Jan 11 to Jan 12
$75 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 24-hour ...
7.6/10 Good! (1,012 reviews)
The staff was very helpful timely check in. Room was clean. The slide lock on room door was totally missing. The elevator ceiling tile was missing giving access to lighting overhead. Vulgar language was inscribed on wall of elevator.
Reviewed on Jan 1, 2026

Spark by Hilton Orangeburg
731 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $97 total per night from Jan 11 to Jan 12
$97 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
7.6/10 Good! (1,004 reviews)
The recent renovations were really nice. My room, along with the other parts of the hotel, was very clean and there was no hesitation to get assistance from the staff when needed. Among the staff, Tomeeka and the Assistant Manager Astria were exceptional! I’m excited to return.
Reviewed on Jan 2, 2026

Best Western Inn
1808 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Jan 8 to Jan 9
$100 total
Jan 8 - Jan 9
Total with taxes and fees
A seasonal outdoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public ...
7.6/10 Good! (1,008 reviews)
Clean rooms. Great staff. Very friendly and helpful.
Reviewed on Jan 3, 2026

Red Roof Inn Florence - Civic Center
2690 David H McLeod Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $63 total per night from Jan 11 to Jan 12
$63 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
6.6/10 (1,001 reviews)
The A/C was a bit difficult to handle. The buttons to change the temperature caused the machine to change between modes settings instead. Not to mention, the room could use some renovating. There was patches of paint just hanging from the ceiling.
Reviewed on Dec 29, 2025
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Pet Friendly Hotel in South Carolina Midlands
South Carolina Midlands hotels essential information
Accommodation | 3,114 hotels |
|---|---|
Lowest Price | $63 |
Highest Price | $131 |
Popular hotels | La Quinta Inn & Suites by Wyndham Florence, La Quinta Inn by Wyndham Columbia SE / Fort Jackson, Hampton Inn Columbia I-26/Harbison Blvd., Spark by Hilton Orangeburg, Quality Inn & Suites Florence Civic Center, Holiday Inn Santee by IHG, Red Roof Inn Florence - Civic Center, Best Western Inn |
Recent South Carolina Midlands hotel reviews by fellow wanderers

Clarion Pointe Rock Hill Near University
5 out of 5
Posted 6 days ago
Travelocity Verified Review
"Clean rooms, kind staff "
A verified traveler stayed at Clarion Pointe Rock Hill Near University

La Quinta Inn by Wyndham Columbia SE / Fort Jackson
5 out of 5
Posted 7 days ago
Travelocity Verified Review
"Very Clean and newly renovated. Decent breakfast and helpful staff."
A verified traveler stayed at La Quinta Inn by Wyndham Columbia SE / Fort Jackson
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