South Carolina Midlands , SC Pet Friendly Hotels

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Top South Carolina Midlands Pet Friendly Hotels

Hampton Inn Columbia I-26/Harbison Blvd.

Hampton Inn Columbia I-26/Harbison Blvd.

101 Woodcross Dr Columbia SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $109 total per night from Jul 26 to Jul 27
$109 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
9.2/10 Wonderful! (1,002 reviews)
"Very nice hotel. Comfortable bed and clean room. Staff very courteous."

Reviewed on Jul 2, 2026

Opens in a new windowHampton Inn Columbia I-26/Harbison Blvd.
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Jul 5 to Jul 6
$100 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
8.6/10 Excellent! (219 reviews)
"Upon arrival I found that the room was attractive, clean, and smelled fresh, no chemical smells or sticky surfaces. I love the colors and simple modern furnishings, comfy bed and fresh, clean bed clothes. I enjoyed being in the room! There was a nice size mini-fridge (with freezer area for ice packs), ..."

Reviewed on Jun 29, 2026

Opens in a new windowQuality Inn & Suites Florence Civic Center
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

7333 Garners Ferry Rd Columbia SC
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $96 total per night from Jul 5 to Jul 6
$96 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
8.2/10 Very Good! (1,004 reviews)
"Staff helpful and welcoming. Breakfast was good. Room was clean and comfortable."

Reviewed on Jul 2, 2026

Opens in a new windowLa Quinta Inn by Wyndham Columbia SE / Fort Jackson
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

139 Bradford Blvd Santee SC
Fully refundable
$100 nightly
The price is $111 total per night from Aug 2 to Aug 3
$111 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8.2/10 Very Good! (1,000 reviews)
"Beds & pillows are very comfortable. Amenities needs some upgrading....I brewed a keurig cup coffee & grinds were in the cup. Toilet to upgrade & shower curtain too small. But very clean!"

Reviewed on May 30, 2026

Opens in a new windowHoliday Inn Santee by IHG
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jul 19 to Jul 20
$106 total
Jul 19 - Jul 20
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
7.8/10 Good! (1,559 reviews)
"Very rude night staff. Stains and hair on bed sheets, the floors were greasy, furniture was beat up, chair in room had paint stain. The pictures of the room showed two queen size beds and a sofa bed. Front staff said the pictures are wrong and it’s a room with two queen size beds only. I booked it ..."

Reviewed on Jun 30, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Florence
Spark by Hilton Orangeburg

Spark by Hilton Orangeburg

731 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jul 26 to Jul 27
$106 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
7.8/10 Good! (1,000 reviews)
"We checked in at 9:00 pm - pool closed room never cooled down- especially the front half of the room where sofa beds is located. left at 6:30 am room was not that cleaned - needs carpet cleaned; all mattress needs to be replaced including sofa bed. Hotel is dark and needs to be cleaned including ..."

Reviewed on Jun 23, 2026

Opens in a new windowSpark by Hilton Orangeburg
Best Western Inn

Best Western Inn

1808 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $80 total per night from Jul 5 to Jul 6
$80 total
Jul 5 - Jul 6
Total with taxes and fees
A seasonal outdoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public ...
7.8/10 Good! (1,001 reviews)
"We enjoyed our stay, Every one was very helpful. Hot Breakfast was great. Clean and comfortable"

Reviewed on Jul 3, 2026

Opens in a new windowBest Western Inn
Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2690 David H McLeod Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $63 total per night from Aug 2 to Aug 3
$63 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
Opens in a new windowRed Roof Inn Florence - Civic Center
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Carolina Midlands hotels essential information

Accommodation
3,280 hotels
Lowest Price
$63
Highest Price
$111
Popular hotels
La Quinta Inn & Suites by Wyndham Florence, La Quinta Inn by Wyndham Columbia SE / Fort Jackson, Hampton Inn Columbia I-26/Harbison Blvd., Spark by Hilton Orangeburg, Quality Inn & Suites Florence Civic Center, Holiday Inn Santee by IHG, Red Roof Inn Florence - Civic Center, Best Western Inn

Recent South Carolina Midlands hotel reviews by fellow wanderers

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