Explore 83 Luxury Hotels in South Carolina Midlands

Name: Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area
Price range: $71 total
Rating: 7

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Best Luxury Hotels in South Carolina Midlands

The Willcox

100 Colleton Avenue SW, Aiken, SC

$286 nightly

$321 total

Aug 25 - Aug 26

Total includes taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

9.6/10 Exceptional! (134 reviews)

"The bathroom and bedroom weren't cleaned well. Property was nice. Beds were comfortable. Pool area was pretty. Food was good. Staff were friendly."

Reviewed on Aug 16, 2025

Carriage House Inn

139 Laurens Street, Northwest , Aiken, SC

Fully refundableReserve now, pay when you stay

$189 nightly

$212 total

Aug 21 - Aug 22

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free breakfast, free WiFi, and free self parking. Business travelers can take advantage of the laundry ...

9.4/10 Exceptional! (440 reviews)

"The staff was extremely polite and attentive."

Reviewed on Aug 17, 2025

The Ballantyne, A Luxury Collection Hotel, Charlotte

10000 Ballantyne Commons Pkwy, Charlotte, NC

Fully refundableReserve now, pay when you stay

$243 nightly

$280 total

Aug 24 - Aug 25

Total includes taxes and fees

A full-service spa, 2 indoor pools, and A 24-hour gym are all featured at this luxury hotel. Families will appreciate the playground and complimentary bicycles. ...

9.2/10 Wonderful! (985 reviews)

"Very nice."

Reviewed on Aug 19, 2025

Inn on the Square, Ascend Hotel Collection

104 Court Avenue East, Greenwood, SC

Fully refundableReserve now, pay when you stay

$118 nightly

$131 total

Sep 7 - Sep 8

Total includes taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference center. ...

9.2/10 Wonderful! (683 reviews)

"Absolutely loved the hotel. Most shops are still in repair from the tragic flood. We love the area. Can’t wait to return after the area recovers and it will thrive once again. 💕"

Reviewed on Aug 17, 2025

The Mantissa Hotel

130 East Carolina Ave, Hartsville, SC

$188 nightly

$211 total

Aug 21 - Aug 22

Total includes taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

9/10 Wonderful! (251 reviews)

"Great location!"

Reviewed on Aug 17, 2025

Sheraton Columbia Downtown Hotel

1400 Main St, Columbia, SC

Fully refundableReserve now, pay when you stay

$107 nightly

$120 total

Sep 14 - Sep 15

Total includes taxes and fees

This hotel features 2 bars/lounges and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. ...

8.2/10 Very Good! (1,006 reviews)

"Water took long to heat up, a bit dingy, you can hear people in the hallways."

Reviewed on Aug 16, 2025

Travelodge by Wyndham Orangeburg

3620 Saint Matthews Rd, Orangeburg, SC

Fully refundableReserve now, pay when you stay

$71 nightly

$79 total

Aug 21 - Aug 22

Total includes taxes and fees

Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.

8/10 Very Good! (1,003 reviews)

"Clean room, comfortable bed, staff was welcoming"

Reviewed on Jul 27, 2025

Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

1047 Riverview Rd, Rock Hill, SC

Fully refundableReserve now, pay when you stay

$64 nightly

$71 total

Sep 7 - Sep 8

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...

7/10 Good! (1,001 reviews)

"You get what you pay for. Rooms were no bad. Breakfast was not one bread was molded. Not very professional"

Reviewed on Jul 13, 2025

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South Carolina Midlands Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South Carolina Midlands luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South Carolina Midlands to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South Carolina Midlands will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South Carolina Midlands, and plan your next opulent escape.

South Carolina Midlands hotels essential information

Accommodation	2,922 hotels
Lowest Price	$71
Highest Price	$321
Popular hotels	The Ballantyne, A Luxury Collection Hotel, Charlotte, The Willcox, The Mantissa Hotel, Travelodge by Wyndham Orangeburg, Carriage House Inn, Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area, Inn on the Square, Ascend Hotel Collection, Sheraton Columbia Downtown Hotel

Popular Luxury Stays in South Carolina Midlands

5 Stars Luxury stays in South Carolina Midlands

Luxury stays in South Carolina Midlands with spa

Recent South Carolina Midlands Hotel Reviews By Fellow Wanderers

Hyatt Place Columbia/Harbison

5 out of 5

Posted 18 hours ago

Travelocity Verified Review

"We stayed 3 nights - visiting from Michigan for a Ft. Jackson graduation. As everyone else seemed to be as well. :) Great staff through & through. It was noisy the first night we checked in, but we chalked it up to all the visitors anticipation of family day at Ft. Jackson. Our bedroom was a king bed and a very comfy couch that could pull out if needed. The bed was like sleeping on a cloud…I was happy happy. However, the pillows…y’all - they felt like they were the size of a couch pillow. Still comfy as all get out, though (I just need more real estate for my noggin). The complimentary breakfast on our last day was amazing! The gal who made the gravy for the biscuits - chef’s kiss. Also, the best freakin’ sourdough bread I’ve ever, had."

A verified traveler stayed at Hyatt Place Columbia/Harbison

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

5 out of 5

Posted 7 days ago

Travelocity Verified Review

"My rooms was very clean and the staff was very friendly they had some maintenance going on which caused some delay but the staff was very understandable and didn’t charge extra, i can definitely see the vision for when the maintenance and upgrades are finished. only thing I didn’t like was the area of the parking lot would 10/10 recommend "

A verified traveler stayed at La Quinta Inn by Wyndham Columbia SE / Fort Jackson