Explore 83 Luxury Hotels in South Carolina Midlands

Name: Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area
Price range: $73 total
Rating: 7

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Best Luxury Hotels in South Carolina Midlands

The Willcox

100 Colleton Avenue SW, Aiken, SC

Fully refundableReserve now, pay when you stay

$286 nightly

$321 total

May 26 - May 27

Total includes taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

9.6/10 Exceptional! (130 reviews)

"Love the room, attention to detail, great restaurant!"

Reviewed on May 12, 2025

Carriage House Inn

139 Laurens Street, Northwest , Aiken, SC

Fully refundableReserve now, pay when you stay

$200 nightly

$224 total

May 18 - May 19

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free breakfast, free WiFi, and free self parking. Business travelers can take advantage of the laundry ...

9.4/10 Exceptional! (428 reviews)

"The CUTEST inn. Very authentic for what it advises. Staff is friendly and welcoming. My room was clean, aesthetically pleasing, and felt like I was literally at my parents house (homey). Also the price was extremely fair. The only down side was there is no fridge! Having it be my first time in Aiken ..."

Reviewed on Apr 6, 2025

The Ballantyne, A Luxury Collection Hotel, Charlotte

10000 Ballantyne Commons Pkwy, Charlotte, NC

Fully refundableReserve now, pay when you stay

$260 nightly

$300 total

May 26 - May 27

Total includes taxes and fees

A full-service spa, 2 indoor pools, and A 24-hour gym are all featured at this luxury hotel. Families will appreciate the playground and complimentary bicycles. ...

9.2/10 Wonderful! (937 reviews)

"Definitely recommend! You will have to pay to use the microwave if needed"

Reviewed on May 12, 2025

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The Mantissa Hotel

130 East Carolina Ave, Hartsville, SC

Fully refundableReserve now, pay when you stay

$180 nightly

$201 total

May 22 - May 23

Total includes taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

9.2/10 Wonderful! (234 reviews)

"My shower glass door was falling apart and nobody was able to secure it back safely"

Reviewed on May 9, 2025

Inn on the Square, Ascend Hotel Collection

104 Court Avenue East, Greenwood, SC

Fully refundableReserve now, pay when you stay

$118 nightly

$131 total

May 22 - May 23

Total includes taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference center. ...

9.2/10 Wonderful! (662 reviews)

"Nice town. Polos. Best restaurant in the world."

Reviewed on May 11, 2025

Sheraton Columbia Downtown Hotel

1400 Main St, Columbia, SC

Fully refundableReserve now, pay when you stay

$108 nightly

$121 total

May 22 - May 23

Total includes taxes and fees

This hotel features 2 bars/lounges and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. ...

8.2/10 Very Good! (1,007 reviews)

"Everyone was so nice and helpful. The bed was comfortable and great location to everything:)"

Reviewed on May 13, 2025

Travelodge by Wyndham Orangeburg

3620 Saint Matthews Rd, Orangeburg, SC

Fully refundableReserve now, pay when you stay

$80 nightly

$89 total

May 18 - May 19

Total includes taxes and fees

Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.

8/10 Very Good! (962 reviews)

Orangeburg

"Good room for the price."

Reviewed on May 10, 2025

Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

1047 Riverview Rd, Rock Hill, SC

Fully refundableReserve now, pay when you stay

$66 nightly

$73 total

Jun 8 - Jun 9

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...

7/10 Good! (1,000 reviews)

"Good location, lots of things to do in the area. Can walk to many different places to eat. Room was clean. Beds were comfortable. Very quiet. We only stayed one night, but got a great night's sleep. Check in was easy and staff was very friendly. I would certainly stay here again."

Reviewed on Mar 29, 2025

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Carolina Midlands Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South Carolina Midlands luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South Carolina Midlands to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South Carolina Midlands will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South Carolina Midlands, and plan your next opulent escape.

South Carolina Midlands hotels essential information

Accommodation	2,856 hotels
Lowest Price	$73 total
Highest Price	$321 total
Popular hotels	The Ballantyne, A Luxury Collection Hotel, Charlotte, The Willcox, The Mantissa Hotel, Travelodge by Wyndham Orangeburg, Carriage House Inn, Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area, Inn on the Square, Ascend Hotel Collection, Sheraton Columbia Downtown Hotel

Popular Luxury Stays in South Carolina Midlands

5 Stars Luxury stays in South Carolina Midlands

Luxury stays in South Carolina Midlands with spa

Popular places to visit

Carowinds Theme Park

4.5/5(482 reviews)

Choose from 13 roller coasters, chase your friends in a bumper car, enjoy the water slides and beaches of Boomerang Bay, and walk with dinosaurs.

Recent South Carolina Midlands Hotel Reviews By Fellow Wanderers

Courtyard by Marriott Columbia Downtown at USC

5 out of 5

Posted 3 days ago

Travelocity Verified Review

"Loved everything about my stay. 3rd time at the hotel and will definitely be back "

A verified traveler stayed at Courtyard by Marriott Columbia Downtown at USC

Sleep Inn Columbia

5 out of 5

Posted 3 days ago

Travelocity Verified Review

"We have stayed here several times for USC events. It is clean, beds are comfy, staff are kind and attentive. It is a bit outdated, but don’t let that turn you off. It’s CLEAN. That’s my one thing I will not cave for. I don’t want bugs, and after 5 stays, we’ve never experienced any. We’ve stayed at higher end hotels and have had horrible experiences. There’s a small breakfast in the am that’s free. There are have been instances of excessive noise, but we go in expecting it’s a hotel and not a private apartment, and also easily addressed. If you’re a parent or friend visiting USC, it’s a 15 min drive to campus or about 15-20 dollar Uber. Their prices are reasonable ( even for grad weekend) and are genuinely very kind people that own and run the hotel. We had 13 people stay there this past weekend with no complaints. "

A verified traveler stayed at Sleep Inn Columbia

Graduate by Hilton Columbia SC

5 out of 5

Posted 6 days ago

Travelocity Verified Review

"Great one night stay after a bad experience at the Moxy - Downtown Columbia and a Police raid during check-in at the Aloft. What's up with Columbia? The Moxy check-in at the bar was a nightmare. A long line of folks waiting to check-in as bartenders were attending drunks - not cool, cutting edge or even remotely hip. The Staff at the Graduate was prompt, incredibly kind and parking was a breeze. "

A verified traveler stayed at Graduate by Hilton Columbia SC

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