Explore 83 Luxury Hotels in South Carolina Midlands

Name: Carriage House Inn
Price range: $200 total

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Best Luxury Hotels in South Carolina Midlands

The Ballantyne, A Luxury Collection Hotel, Charlotte

10000 Ballantyne Commons Pkwy Charlotte NC

Fully refundableReserve now, pay when you stay

$260 nightly

$300 total

Mar 29 - Mar 30

Total with taxes and fees

A full-service spa, 2 restaurants, and an indoor pool are all featured at this smoke-free hotel. Families will appreciate the playground and complimentary bicycles. ...

9.2/10 Wonderful! (1,000 reviews)

Breakfast menu was not good. Eat breakfast off property.

Reviewed on Mar 16, 2026

Inn on the Square, an Ascend Collection Hotel

104 Court Avenue East Greenwood SC

Fully refundable

$118 nightly

$131 total

Apr 12 - Apr 13

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference center. ...

9.2/10 Wonderful! (725 reviews)

Hailey upon checking in did not give me any info on what was on site, hours, etc, The card did not work to enter bldg then my card did not work to enter room and room had a slight smell of urine possibly not sure but a slightly foul odor

Reviewed on Mar 19, 2026

Sheraton Columbia Downtown Hotel

1400 Main St Columbia SC

Fully refundableReserve now, pay when you stay

$119 nightly

$133 total

Mar 29 - Mar 30

Total with taxes and fees

This hotel features 2 bars/lounges and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. ...

8.4/10 Very Good! (1,000 reviews)

Short business trip. Staff was very welcoming and all very good. I would stay again.

Reviewed on Mar 16, 2026

Travelodge by Wyndham Orangeburg

3620 Saint Matthews Rd Orangeburg SC

Fully refundableReserve now, pay when you stay

$71 nightly

$79 total

Mar 22 - Mar 23

Total with taxes and fees

Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.

8.2/10 Very Good! (1,002 reviews)

Property was easy to find, room was clean, restaurants close, front desk staff was super friendly, comfortable bed. All good. Would stay again

Reviewed on Mar 18, 2026

Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

1047 Riverview Rd Rock Hill SC

Fully refundableReserve now, pay when you stay

$57 nightly

$63 total

Mar 23 - Mar 24

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...

7/10 Good! (1,000 reviews)

Checked out early for a long drive home and was told I couldn’t get any paperwork as it wasn’t 4 am. Not even something to get my security back. The employee who was working could barely pry himself from his video game and headset. Acted as if I was bothering him. 0/10 rating

Reviewed on Mar 4, 2026

The Willcox

100 Colleton Avenue SW Aiken SC

$321 nightly

$359 total

Mar 24 - Mar 25

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

The Mantissa Hotel

130 East Carolina Ave Hartsville SC

Fully refundableReserve now, pay when you stay

$162 nightly

$181 total

Mar 29 - Mar 30

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

Carriage House Inn

139 Laurens Street, Northwest Aiken SC

Fully refundableReserve now, pay when you stay

$179 nightly

$200 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free breakfast, free WiFi, and free self parking. Business travelers can take advantage of the laundry ...

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More 4 star hotels in South Carolina Midlands

Steps to Lake Greenwood: Waterfront Gem w/ Patio

Greenwood SC

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10/10 Exceptional! (2 reviews)

South Carolina Midlands Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South Carolina Midlands luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South Carolina Midlands to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South Carolina Midlands will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South Carolina Midlands, and plan your next opulent escape.

South Carolina Midlands hotels essential information

Accommodation	3,215 hotels
Lowest Price	$63
Highest Price	$359
Popular hotels	The Ballantyne, A Luxury Collection Hotel, Charlotte, The Willcox, The Mantissa Hotel, Travelodge by Wyndham Orangeburg, Carriage House Inn, Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area, Inn on the Square, an Ascend Collection Hotel, Sheraton Columbia Downtown Hotel

Popular Luxury Stays in South Carolina Midlands

5 Stars Luxury stays in South Carolina Midlands

Luxury stays in South Carolina Midlands with spa

Recent South Carolina Midlands Hotel Reviews By Fellow Wanderers

Baymont by Wyndham Columbia Northwest

2 out of 5

Posted 4 hours ago

Travelocity Verified Review

"It was definitely pet friendly. Pet hair was everywhere, it smelled awful. There were dogs barking the entire night. This was just a stop on the leg of our journey and we could not wait to leave."

A verified traveler stayed at Baymont by Wyndham Columbia Northwest

Graduate by Hilton Columbia SC

3 out of 5

Posted 17 hours ago

Travelocity Verified Review

"Everything was fine except the cleanliness of the bathroom … and that made it all bad! It was so, SO GROSS, to find little hairs all over the bathroom door and shower door - pubic hairs and very short hairs everywhere! The shower itself was also dirty. It had dark mold in the grout in one spot and orangey mold in the grout in another spot. I took photos to share. Had the room been clean, this would have been a charming hotel we would stay at again, no complaints. But this made it sketchy and gross "

A verified traveler stayed at Graduate by Hilton Columbia SC