Explore 83 Luxury Hotels in South Carolina Midlands

Name: Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area
Price range: $66 total
Rating: 7

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Best Luxury Hotels in South Carolina Midlands

The Willcox

100 Colleton Avenue SW Aiken SC

Fully refundableReserve now, pay when you stay

$286 nightly

$321 total

Dec 8 - Dec 9

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

9.6/10 Exceptional! (142 reviews)

What an amazing find! The rooms and the staff were amazing our only regret was that we were only staying for the one night. We are already planning an extended stay at the Willcox.

Reviewed on Nov 5, 2025

Carriage House Inn

139 Laurens Street, Northwest Aiken SC

Fully refundableReserve now, pay when you stay

$199 nightly

$223 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free breakfast, free WiFi, and free self parking. Business travelers can take advantage of the laundry ...

9.4/10 Exceptional! (459 reviews)

Friendly and helpful staff that truly make you feel like a priority. Beautiful historic/boutique hotel in the heart of downtown Aiken. 10/10 will stay here again!

Reviewed on Nov 7, 2025

The Ballantyne, A Luxury Collection Hotel, Charlotte

10000 Ballantyne Commons Pkwy Charlotte NC

Fully refundableReserve now, pay when you stay

$217 nightly

$250 total

Dec 22 - Dec 23

Total with taxes and fees

A full-service spa, 2 indoor pools, and A 24-hour gym are all featured at this luxury hotel. Families will appreciate the playground and complimentary bicycles. ...

9.2/10 Wonderful! (1,000 reviews)

I will admit I had some reservations due to the price per hotel room, but the staff's professional nature and quick responses were exceptional. The decor and luxuriousness definitely made me feel like a VIP. I would certainly stay here again- especially for the quality of the bed and the shower!

Reviewed on Nov 12, 2025

Inn on the Square, an Ascend Collection Hotel

104 Court Avenue East Greenwood SC

Fully refundable

$110 nightly

$122 total

Dec 21 - Dec 22

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference center. ...

9.2/10 Wonderful! (703 reviews)

Reviewed on Nov 9, 2025

The Mantissa Hotel

130 East Carolina Ave Hartsville SC

Fully refundableReserve now, pay when you stay

$162 nightly

$181 total

Nov 30 - Dec 1

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

9/10 Wonderful! (268 reviews)

The location was conviene and the area was quite.

Reviewed on Oct 26, 2025

Sheraton Columbia Downtown Hotel

1400 Main St Columbia SC

Fully refundableReserve now, pay when you stay

$111 nightly

$124 total

Nov 24 - Nov 25

Total with taxes and fees

This hotel features 2 bars/lounges and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. ...

8.2/10 Very Good! (1,003 reviews)

I will be coming back to the Sheraton for sure great hotel amazing service and staff rooftop bar is really great as well.

Reviewed on Nov 13, 2025

Travelodge by Wyndham Orangeburg

3620 Saint Matthews Rd Orangeburg SC

Fully refundableReserve now, pay when you stay

$67 nightly

$75 total

Dec 1 - Dec 2

Total with taxes and fees

Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.

8/10 Very Good! (1,004 reviews)

Not much offered for breakfast.

Reviewed on Nov 16, 2025

Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

1047 Riverview Rd Rock Hill SC

Fully refundableReserve now, pay when you stay

$60 nightly

$66 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...

7/10 Good! (1,004 reviews)

The beds were excellent. The room was fine. The bathroom sink had no cold water that we could find. All hot, no matter how the faucet was set

Reviewed on Nov 15, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Carolina Midlands Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South Carolina Midlands luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South Carolina Midlands to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South Carolina Midlands will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South Carolina Midlands, and plan your next opulent escape.

South Carolina Midlands hotels essential information

Accommodation	3,012 hotels
Lowest Price	$66
Highest Price	$321
Popular hotels	The Ballantyne, A Luxury Collection Hotel, Charlotte, The Willcox, The Mantissa Hotel, Travelodge by Wyndham Orangeburg, Carriage House Inn, Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area, Inn on the Square, an Ascend Collection Hotel, Sheraton Columbia Downtown Hotel