Explore 83 Luxury Hotels in South Carolina Midlands
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Best Luxury Hotels in South Carolina Midlands
The Willcox
100 Colleton Avenue SW Aiken SC
Fully refundableReserve now, pay when you stay
$286 nightly
The price is $321 total per night from Feb 2 to Feb 3
$321 total
Feb 2 - Feb 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
9.6/10 Exceptional! (146 reviews)
Pet friendly! They even brought up fluffy dog beds and treats. Staff was wonderful
Reviewed on Jan 7, 2026
Carriage House Inn
139 Laurens Street, Northwest Aiken SC
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $223 total per night from Feb 4 to Feb 5
$223 total
Feb 4 - Feb 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast, free WiFi, and free self parking. Business travelers can take advantage of the laundry ...
9.4/10 Exceptional! (466 reviews)
Spotless room. Cookies and coffee 24/7. Very helpful and friendly staff. Ideal location.
Reviewed on Jan 18, 2026
The Ballantyne, A Luxury Collection Hotel, Charlotte
10000 Ballantyne Commons Pkwy Charlotte NC
Fully refundableReserve now, pay when you stay
$312 nightly
The price is $360 total per night from Feb 19 to Feb 20
$360 total
Feb 19 - Feb 20
Total with taxes and fees
A full-service spa, 2 restaurants, and an indoor pool are all featured at this smoke-free hotel. Families will appreciate the playground and complimentary bicycles. ...
9.2/10 Wonderful! (1,002 reviews)
Staff and cleanliness
Reviewed on Jan 20, 2026
The Mantissa Hotel
130 East Carolina Ave Hartsville SC
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $146 total per night from Feb 1 to Feb 2
$146 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...
9/10 Wonderful! (274 reviews)
This was an outstanding hotel We will stay again when in town
Reviewed on Jan 18, 2026
Inn on the Square, an Ascend Collection Hotel
104 Court Avenue East Greenwood SC
Fully refundable
$105 nightly
The price is $116 total per night from Mar 1 to Mar 2
$116 total
Mar 1 - Mar 2
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference center. ...
9/10 Wonderful! (712 reviews)
Exceptionally friendly staff. So helpful.
Reviewed on Jan 21, 2026
Sheraton Columbia Downtown Hotel
1400 Main St Columbia SC
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $142 total per night from Feb 8 to Feb 9
$142 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features 2 bars/lounges and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. ...
8.2/10 Very Good! (1,004 reviews)
I don’t have much to say because I expected more fro Sheraton. 1.The TV went out, 2. I was given a room with a blocked view, 3. The bar was not open in the evening to have cocktails. 4. No room service but the website indicated it did. 5. Breakfast sucked.
Reviewed on Jan 21, 2026
Travelodge by Wyndham Orangeburg
3620 Saint Matthews Rd Orangeburg SC
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $79 total per night from Feb 1 to Feb 2
$79 total
Feb 1 - Feb 2
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.
8/10 Very Good! (1,000 reviews)
Best value for money
Reviewed on Jan 16, 2026
Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area
1047 Riverview Rd Rock Hill SC
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $67 total per night from Feb 1 to Feb 2
$67 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
6.8/10 (1,001 reviews)
I enjoyed the amenities, the room was nice but 95% of the staff was friendly and helpful
Reviewed on Jan 17, 2026
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See all available properties in South Carolina Midlands
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
South Carolina Midlands Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South Carolina Midlands luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in South Carolina Midlands to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in South Carolina Midlands will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South Carolina Midlands, and plan your next opulent escape.
South Carolina Midlands hotels essential information
Accommodation | 3,135 hotels |
|---|---|
Lowest Price | $67 |
Highest Price | $360 |
Popular hotels | The Ballantyne, A Luxury Collection Hotel, Charlotte, The Willcox, The Mantissa Hotel, Travelodge by Wyndham Orangeburg, Carriage House Inn, Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area, Inn on the Square, an Ascend Collection Hotel, Sheraton Columbia Downtown Hotel |
Popular Luxury Stays in South Carolina Midlands
Recent South Carolina Midlands Hotel Reviews By Fellow Wanderers
Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Check-in process was simple and easy. We did have to switch rooms due to thermostat being broken in the 1st room. However they made up for it with a first class breakfast the next morning. Enjoyed the stay."
A verified traveler stayed at Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG
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