Book Hotels in O Brien, FL
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Top O Brien hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
obrien FL
A gym is featured at this vacation home, along with a garden and laundry facilities. There's fun for all ages with a playground and an arcade/game room, and ...
Very welcoming and personable hosts. They came over to relatives house and had dinner with us. Very relaxed environment with family and friends.
Reviewed on Jan 11, 2026

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
1699 NE Co Rd 337 High Springs FL
$199 nightly
The price is $219 total per night from Feb 2 to Feb 3
$219 total
Feb 2 - Feb 3
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
This is the perfect place to disconnect and reconnect with yourself. The cabin and amenities were great.
Reviewed on Jan 22, 2026

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD Alachua FL
Fully refundable
$113 nightly
The price is $127 total per night from Feb 1 to Feb 2
$127 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Our room was clean, good amenities however apparently the next room brought in a dog that did a lot of barking the front seat did not do anything about the situation.
Reviewed on Jan 25, 2026

Courtyard By Marriott Lake City
3004 West US HWY 90 Lake City FL
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $120 total per night from Feb 8 to Feb 9
$120 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Free self parking, ...
Nice and clean. Friendly staff.
Reviewed on Jan 24, 2026

Hampton Inn & Suites Lake City
450 SW Florida Gateway Drive Lake City FL
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $134 total per night from Feb 1 to Feb 2
$134 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Clean. Friendly staff. Good breakfast options.
Reviewed on Jan 23, 2026

Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $120 total per night from Feb 1 to Feb 2
$120 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Clean and staff was very kind
Reviewed on Jan 20, 2026

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $116 total per night from Feb 1 to Feb 2
$116 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Have had very good luck with Best Western Plus hotels and this one was great! Breakfast was good every morning, staff was incredibly friendly and the hotel was well maintained.
Reviewed on Jan 25, 2026

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $112 total per night from Feb 22 to Feb 23
$112 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Nice walking area for dogs. Walking to restaurants too.
Reviewed on Jan 26, 2026

Holiday Inn & Suites Lake City by IHG
213 Sw Commerce Dr Lake City FL
Fully refundable
$87 nightly
The price is $98 total per night from Feb 1 to Feb 2
$98 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Yes. I enjoyed my stay.
Reviewed on Jan 26, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent O Brien hotel reviews by fellow wanderers

La Quinta Inn & Suite by Wyndham Lake City
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Nice walking area for dogs. Walking to restaurants too. "
A verified traveler stayed at La Quinta Inn & Suite by Wyndham Lake City
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