Book Hotels in O Brien, FL
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Top O Brien hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
obrien FL
A gym is featured at this vacation home, along with a garden and laundry facilities. There's fun for all ages with a playground and an arcade/game room, and ...
Awesome place in a location that is perfect for visiting the springs. Had a great time and would return.
Reviewed on Nov 29, 2025

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
1699 NE Co Rd 337 High Springs FL
$179 nightly
The price is $197 total per night from Jan 5 to Jan 6
$197 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
Very good, Nice
Reviewed on Dec 18, 2025

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD Alachua FL
Fully refundable
$113 nightly
The price is $127 total per night from Dec 28 to Dec 29
$127 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Easy check in, friendly staff, hot tub, nice clean rooms.
Reviewed on Dec 23, 2025

Hampton Inn & Suites Lake City
450 SW Florida Gateway Drive Lake City FL
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $131 total per night from Jan 11 to Jan 12
$131 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Room seemed freshly updated; spacious room with functional layout; bathroom had nice fixtures, good water pressure, and hot water; breakfast was great with many options and fully stocked items presented beautifully; lobby and dining area are tastefully decorated and functional; hotel staff was pleasant ...
Reviewed on Dec 23, 2025

Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $113 total per night from Jan 4 to Jan 5
$113 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Very nice lady at the front desk. Clean room. Nice place
Reviewed on Dec 22, 2025

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Dec 28 to Dec 29
$98 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Wonderful! Our room was clean and very comfortable and spacious. Staff have been kind and helpful.
Reviewed on Dec 21, 2025

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Dec 28 to Dec 29
$105 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Clean and comfortable rooms
Reviewed on Dec 21, 2025

Holiday Inn & Suites Lake City by IHG
213 Sw Commerce Dr Lake City FL
Fully refundable
$95 nightly
The price is $107 total per night from Jan 11 to Jan 12
$107 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Nice hotel but a little pricey
Reviewed on Dec 20, 2025

Motel 6 – Lake City, Fl – Medical Center
3340 W US Highway 90 Lake City FL
Fully refundable
$61 nightly
The price is $69 total per night from Dec 28 to Dec 29
$69 total
Dec 28 - Dec 29
Total with taxes and fees
Staff at the 24-hour front desk can provide around-the-clock assistance. Take advantage of the free self parking.
Great staff. accommodating
Reviewed on Dec 16, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent O Brien hotel reviews by fellow wanderers

Hampton Inn & Suites Lake City
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Room seemed freshly updated; spacious room with functional layout; bathroom had nice fixtures, good water pressure, and hot water; breakfast was great with many options and fully stocked items presented beautifully; lobby and dining area are tastefully decorated and functional; hotel staff was pleasant and helpful- offered coupons to local food and suggestions of things to do while our room was being prepared. Overall, a great hotel for a family with littles."
A verified traveler stayed at Hampton Inn & Suites Lake City
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