Book Hotels in O Brien, FL

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Top O Brien hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien FL
A gym is featured at this vacation home, along with a garden and laundry facilities. There's fun for all ages with a playground and an arcade/game room, and ...
Very welcoming and personable hosts. They came over to relatives house and had dinner with us. Very relaxed environment with family and friends.

Reviewed on Jan 11, 2026

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Opens in a new windowRoyal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

2 out of 5
1699 NE Co Rd 337 High Springs FL
$173 nightly
The price is $190 total per night from Jan 26 to Jan 27
$190 total
Jan 26 - Jan 27
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
We had such a great time, the cabin was nice and clean and had everything you might need. We loved the little detail of the handwritten postcard and map! The fireplace area was so nice too, perfect for a little getaway!

Reviewed on Jan 13, 2026

Opens in a new windowPostcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD Alachua FL
Fully refundable
$115 nightly
The price is $129 total per night from Jan 22 to Jan 23
$129 total
Jan 22 - Jan 23
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Excellent staff

Reviewed on Jan 12, 2026

Opens in a new windowHoliday Inn Express & Suites Alachua - Gainesville Area by IHG
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3 out of 5
3004 West US HWY 90 Lake City FL
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $114 total per night from Jan 25 to Jan 26
$114 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Free self parking, ...
The best part of this stay was a room with 2 king beds!!!!! Property was in excellent condition and front desk person was super. Highly recommend.

Reviewed on Jan 6, 2026

Opens in a new windowCourtyard By Marriott Lake City
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

2.5 out of 5
450 SW Florida Gateway Drive Lake City FL
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $140 total per night from Jan 21 to Jan 22
$140 total
Jan 21 - Jan 22
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Room was spotless and great atmosphere

Reviewed on Jan 15, 2026

Opens in a new windowHampton Inn & Suites Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court Lake City FL
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $113 total per night from Jan 25 to Jan 26
$113 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Close to I75. Clean, safe, sleek in decor.

Reviewed on Jan 17, 2026

Opens in a new windowTru by Hilton Lake City
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr Lake City FL
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $112 total per night from Jan 20 to Jan 21
$112 total
Jan 20 - Jan 21
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Fresh breakfast

Reviewed on Jan 12, 2026

Opens in a new windowBest Western Plus Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jan 25 to Jan 26
$106 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Room was clean and all the staff were very nice.

Reviewed on Jan 11, 2026

Opens in a new windowLa Quinta Inn & Suite by Wyndham Lake City
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

2.5 out of 5
6694 Us Highway 129 Live Oak FL
Fully refundable
$107 nightly
The price is $118 total per night from Jan 25 to Jan 26
$118 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
This hotel is super convenient to I 10, road noise was no problem. I had a very quiet night on a comfortable bed. The cinnamon rolls on the breakfast bar are yummy! Also, check in was much faster than other hotels I’ve stayed in recently.

Reviewed on Jan 11, 2026

Opens in a new windowHoliday Inn Express & Suites Live Oak by IHG
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in O Brien?
Family vacations are where treasured memories are made, but traveling with youngsters can be tricky. These kid-friendly O Brien hotels offer perks designed to keep adventurers of all ages relaxed and happy: The whole team will enjoy staying at Cozy OBrien Home w/Fire Pit & Patio Near 3 Rivers. A firepit and free WiFi are just a few of the things that help make this hotel an attractive option. 1 ½ Acre OBrien Home with Fire Pit - Near River! is another top place to stay. After a big day of exploring, return to your comfy room and amenities like a deck and a firepit.
Where can I find cheap hotels in O Brien?
At Travelocity you'll find really nice hotels in O Brien at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near O Brien rather than in O Brien. We may find you even better rates, too.
How do I find the best O Brien hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in O Brien then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in O Brien?
The cheapest hotel in O Brien is $106. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in O Brien?
There are 354 hotels in O Brien on Travelocity.
What are the best hotels in O Brien?
O Brien has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in O Brien for you!
When is the best time to visit O Brien?
If you want the joy of a fun-filled trip in peak season, visit O Brien during March, November and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, April and June.
When is the cheapest time to stay in O Brien?
Based on historic data is usually the cheapest month to visit O Brien. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in O Brien?
There are multiple hotels in O Brien that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to O Brien. We have plenty of kid-friendly hotels in O Brien to choose from on Travelocity!
Why book a hotel in O Brien through Travelocity?
Because we have the top hotels in O Brien! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in O Brien on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent O Brien hotel reviews by fellow wanderers

Tru by Hilton Lake City

Tru by Hilton Lake City

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Close to I75. Clean, safe, sleek in decor."
A verified traveler from Huntsville stayed at Tru by Hilton Lake City
Tru by Hilton Lake City

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