Book Hotels in O Brien, FL
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top O Brien hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
obrien FL
A gym is featured at this vacation home, along with a garden and laundry facilities. There's fun for all ages with a playground and an arcade/game room, and ...
Awesome place - the kid's had a blast!
Reviewed on Jan 4, 2026

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
1699 NE Co Rd 337 High Springs FL
$179 nightly
The price is $197 total per night from Jan 13 to Jan 14
$197 total
Jan 13 - Jan 14
Total with taxes and fees
This cabin features a virtual front desk. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including ...
The cabins were extremely clean. Great place to getaway… can’t wait to go back! Such a cute setup… Great location for exploring state parks. No complaints personally… perfect getaway whether alone or with someone A++++
Reviewed on Dec 24, 2025

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD Alachua FL
Fully refundable
$115 nightly
The price is $129 total per night from Jan 14 to Jan 15
$129 total
Jan 14 - Jan 15
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Yes, only when i arrived woman on front desk, told me pool wad heated. It wasm't the pool was freezing. Fan in bath room didn't work. Breaskfast was great. Maid service was friendly and nice. Front Desk emplyees weren"t as friendly except one that worked the second day shift.
Reviewed on Jan 10, 2026

Hampton Inn & Suites Lake City
450 SW Florida Gateway Drive Lake City FL
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $128 total per night from Jan 18 to Jan 19
$128 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Excellent staff and clean organized room
Reviewed on Jan 10, 2026

Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $113 total per night from Jan 18 to Jan 19
$113 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
We always try to find Tru by Hilton on our many road trips.
Reviewed on Jan 5, 2026

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $113 total per night from Jan 18 to Jan 19
$113 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Room was good but the toilet ran all night
Reviewed on Jan 8, 2026

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jan 18 to Jan 19
$106 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Excellent!
Reviewed on Jan 7, 2026

Motel 6 – Lake City, Fl – Medical Center
3340 W US Highway 90 Lake City FL
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $75 total per night from Feb 1 to Feb 2
$75 total
Feb 1 - Feb 2
Total with taxes and fees
Staff at the 24-hour front desk can provide around-the-clock assistance. Take advantage of the free self parking.
Very clean room with a huge TV with a safe well lit parking lot. A great staff and a large room with a couch and comfortable chairs.
Reviewed on Dec 27, 2025

Holiday Inn Express & Suites Live Oak by IHG
6694 Us Highway 129 Live Oak FL
Fully refundable
$107 nightly
The price is $118 total per night from Jan 18 to Jan 19
$118 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests ...
Great beds
Reviewed on Jan 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent O Brien hotel reviews by fellow wanderers

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
5 out of 5
Posted 20 hours ago
Travelocity Verified Review
"Fast and easy "
A verified traveler stayed at Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Explore More Ways to Travel with Travelocity
- Hotels near Lake DeSoto Farmers Market
- Hotels near Troy Spring State Park
- Apartments in Live Oak
- B&B in Live Oak
- Cabins in Live Oak
- Cottages in Live Oak
- Extended Stay Hotels in Live Oak
- Hotels with Pools in Live Oak
- Hotels with Hot Tubs in Live Oak
- Hotels with Restaurants in Live Oak
- Pet Friendly Hotels in Live Oak
- Spa Resorts & in Live Oak
- Live Oak Hotels
- Motels in Live Oak
- Vacation Homes in Live Oak
- Rv Parks in Live Oak
- Hotels near Ichetucknee Springs State Park
- Hotels near Santa Fe River
- Hotels near Ruth B. Kirby Gilchrist Blue Springs State Park
- Hotels near North Florida Speedway
- Hotels near Epiphany Catholic Church
- Hotels near First Federal Sportsplex
- Apartments in Mayo
- Cabins in Mayo
- Condos in Mayo
- Cheap Hotels in Mayo
- Mayo Hotels
- Motels in Mayo
- Vacation Homes in Mayo
- Hotels near Ichetucknee River
- Lake City Hotels
- Resorts in Alton
- Hotels near Florida Department of Transportation
- Hotels near Poe Springs Park
- Hotels near Southside Recreation Complex
- Hotels near Wes Skiles Peacock Springs State Park
- Bell Hotels
- Apartments in Wellborn
- B&B in Wellborn
- Cabins in Wellborn
- Cottages in Wellborn
- Wellborn Hotels
- Motels in Wellborn
- Rv Parks in Wellborn
- Hotels near Lake City Mall
- Hotels near Lafayette Blue Springs State Park
- 3 Star Hotels in Branford
- Cabins in Branford
- Guest Houses in Branford
- Branford Hotels
- Motels in Branford
- Vacation Homes in Branford
- Rv Parks in Branford
- Apartments in Mcalpin
- Mcalpin Hotels
- Motels in Mcalpin
- Rv Parks in Mcalpin
- Hotels near Columbia County Courthouse
- Hotels near Lake City Veterans Affairs Medical Center
- Hotels near Bob's River Place
- Hotels near Ginnie Spring
- Hotels near Lake City Columbia County Historical Museum
- Hotels near Pine Grove Baptist Church
- Apartments in Fort White
- B&B in Fort White
- Cabins in Fort White
- Condos in Fort White
- Cottages in Fort White
- Historic Hotels in Fort White
- Romantic Getaways & Hotels in Fort White
- Fort White Hotels
- Motels in Fort White
- Vacation Homes in Fort White
- Rv Parks in Fort White
- Hotels near Southside Sports Complex
- Flights to Live Oak
- Flights from Atlanta to Live Oak
- Flights from Kansas City to Live Oak
- Flights from Raleigh to Live Oak
- Flights from Madison to Live Oak
- Flights to Mayo
- Flights to Wellborn
- Flights to Branford
- Flights to Fort White
- Flights from Edmonton to Fort White
- Flights from Birmingham to Fort White






