Explore 35 Luxury Hotels in Key West Historic District

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Best Luxury Hotels in Key West Historic District

H2O Suites - Adults Only

H2O Suites - Adults Only

1212 Simonton Street Key West FL
$499 nightly
The price is $561 total per night from May 26 to May 27
$561 total
May 26 - May 27
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Business travelers can take advantage of the laundry service. There's a gym on site, and ...
9.8/10 Exceptional! (599 reviews)
This resort was in the perfect location for exploring Key West. Highly recommend!

Reviewed on Apr 23, 2026

Opens in a new windowH2O Suites - Adults Only
The Gardens Hotel

The Gardens Hotel

526 Angela Street Key West FL
$233 nightly
The price is $262 total per night from May 28 to May 29
$262 total
May 28 - May 29
Total with taxes and fees
2 outdoor pools, 2 bars/lounges, and a restaurant are among this bed & breakfast's featured amenities. Business travelers can take advantage of the free WiFi ...
9.8/10 Exceptional! (1,000 reviews)
This was one of the nicest places we have ever stayed. It felt like a tropical oasis but was only a block over from Duval. Wine tasting room was great and the hotel cat, Lucy, was the sweetest! Breakfast each morning was amazing! We would definitely stay here again when we come back to visit!

Reviewed on Apr 26, 2026

Opens in a new windowThe Gardens Hotel
The Marquesa Hotel

The Marquesa Hotel

600 Fleming Street Key West FL
$379 nightly
The price is $426 total per night from May 31 to Jun 1
$426 total
May 31 - Jun 1
Total with taxes and fees
This hotel features 3 outdoor pools, a restaurant, and a bar/lounge. Business travelers can take advantage of the laundry service. Self parking, a terrace, and ...
9.8/10 Exceptional! (1,000 reviews)
Wow! The property was absolutely breathtaking! The staff was amazing! Keith, Gemma and Andoli were the best. They took the best care of us. Love them. ❤️

Reviewed on Apr 20, 2026

Opens in a new windowThe Marquesa Hotel
Silver Palms Inn

Silver Palms Inn

830 Truman Ave Key West FL
Fully refundableReserve now, pay when you stay
$230 nightly
The price is $259 total per night from May 31 to Jun 1
$259 total
May 31 - Jun 1
Total with taxes and fees
An outdoor pool is featured at this hotel, along with free WiFi in public areas and luggage storage. Enjoy the free continental breakfast each morning. There's ...
9.4/10 Exceptional! (1,028 reviews)
Our room was spacious and very clean. Staff were helpful and professional. Amazing free breakfast with a made to order omelet bar made to order by chef. Free parking, but spaces could e tight if you had a larger vehicle. I would definitely recommend this site in Key West

Reviewed on Apr 29, 2026

Opens in a new windowSilver Palms Inn
Duval House

Duval House

815 Duval St Key West FL
$200 nightly
The price is $222 total per night from May 3 to May 4
$222 total
May 3 - May 4
Total with taxes and fees
This bed & breakfast features a terrace, concierge services, and self parking. A garden, a picnic area, and express check-in are also on offer.
9.4/10 Exceptional! (1,027 reviews)
Excellent place to stay right in Duval street! Everything is walkable. The breakfast was great! Nice, clean rooms and friendly staff. We will definitely stay again on our next visit to Key West!

Reviewed on Apr 29, 2026

Opens in a new windowDuval House
The Marker Key West Harbor Resort

The Marker Key West Harbor Resort

200 William Street Key West FL
Fully refundable
$340 nightly
The price is $382 total per night from May 25 to May 26
$382 total
May 25 - May 26
Total with taxes and fees
This smoke-free hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
9.2/10 Wonderful! (1,003 reviews)
Fourth time in Key West…first time at The Marker. Absolutely loved our stay. Fun atmosphere, great staff - especially at the bar - and well appointed rooms with comfortable beds. All in a great location with gorgeous views. Will definitely be back.

Reviewed on Apr 26, 2026

Opens in a new windowThe Marker Key West Harbor Resort
The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only

413 Applerouth Lane Key West FL
Fully refundableReserve now, pay when you stay
$205 nightly
The price is $231 total per night from May 25 to May 26
$231 total
May 25 - May 26
Total with taxes and fees
This guesthouse features an outdoor pool and a hot tub. Enjoy the free continental breakfast each morning. Self parking, a terrace, and a garden are also ...
8.8/10 Excellent! (1,006 reviews)
Breakfast was good. Staff very courteous, helpful and friendly

Reviewed on Apr 27, 2026

Opens in a new windowThe Cabana Inn Key West - Adults Only
La Concha Key West, Autograph Collection

La Concha Key West, Autograph Collection

430 Duval St Key West FL
Fully refundableReserve now, pay when you stay
$284 nightly
The price is $320 total per night from May 13 to May 14
$320 total
May 13 - May 14
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
Opens in a new windowLa Concha Key West, Autograph Collection
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More 4 star hotels in Key West Historic District

Key West Historic District Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Key West Historic District luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Key West Historic District to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Key West Historic District will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Key West Historic District, and plan your next opulent escape.


Key West Historic District hotels essential information

Accommodation
1,697 hotels
Lowest Price
$222
Highest Price
$561
Popular hotels
The Marker Key West Harbor Resort, H2O Suites - Adults Only, La Concha Key West, Autograph Collection, Silver Palms Inn, Duval House, The Cabana Inn Key West - Adults Only, The Gardens Hotel, The Marquesa Hotel

Popular Luxury Stays in Key West Historic District

Recent Key West Historic District Hotel Reviews By Fellow Wanderers

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