Book Hotels in Clarksdale, MO
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Top Clarksdale hotels

Drury Inn & Suites St Joseph
4213 Frederick Ave St. Joseph MO
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $126 total per night from Apr 29 to Apr 30
$126 total
Apr 29 - Apr 30
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Great place to stay! Will definitely be back.
Reviewed on Apr 21, 2026

Stoney Creek Hotel St. Joseph
1201 N Woobine Rd St. Joseph MO
$124 nightly
The price is $143 total per night from Apr 23 to Apr 24
$143 total
Apr 23 - Apr 24
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
Great sray. Clean and welcoming
Reviewed on Apr 20, 2026

My Place Hotel St Joseph MO
3621 N Village Dr St. Joseph MO
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $94 total per night from May 17 to May 18
$94 total
May 17 - May 18
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the 24-hour business center. ...
Clean room and friendly
Reviewed on Apr 21, 2026

Red Roof Inn Cameron
501 Northland Drive Cameron MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $100 total per night from Apr 26 to Apr 27
$100 total
Apr 26 - Apr 27
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like continental breakfast and WiFi ...
Nice staff, very clean room and facility, great breakfast.
Reviewed on Apr 17, 2026

Super 8 by Wyndham Cameron
1710 N Walnut St Cameron MO
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $88 total per night from Apr 28 to Apr 29
$88 total
Apr 28 - Apr 29
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
Ok stay for one night, breakfast was bland. Needs more flavor. Coffee was bad
Reviewed on Apr 20, 2026

Quality Inn Cameron
1803 Comfort Ln Cameron MO
Fully refundable
$111 nightly
The price is $123 total per night from May 21 to May 22
$123 total
May 21 - May 22
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free buffet breakfast each morning. A computer station, luggage ...
Yes everything was great!
Reviewed on Apr 19, 2026

Hampton Inn St. Joseph
3928 Frederick Ave St. Joseph MO
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $99 total per night from May 17 to May 18
$99 total
May 17 - May 18
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Unfortunately, my experience did not meet expectations, particularly for a stay longer than two days. The beds were extremely hard, which made it uncomfortable over the course of my visit. Additionally, the pool was out of service. I only learned during my stay that it had been unavailable for quite ...
Reviewed on Apr 21, 2026

SureStay Hotel by Best Western Cameron
2210 US Highway 36 Cameron MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $77 total per night from Apr 28 to Apr 29
$77 total
Apr 28 - Apr 29
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Staff at the 24-hour front desk can provide ...
It was difficult to find the office. The cleaners were cleaning our room while we checked in and we had to wait for them even though we arrived an hour and a half after check in time. The room conditions were run down and in need of repair. The door did not fit correctly when closed. The cleaning ...
Reviewed on Apr 14, 2026

AmeriStay Inn
4502 SE US HWY 169 St. Joseph MO
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $89 total per night from Apr 29 to Apr 30
$89 total
Apr 29 - Apr 30
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free continental breakfast each morning. Express check-out, ...
Our overall stay was good.
Reviewed on Apr 16, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Clarksdale hotel reviews by fellow wanderers

Drury Inn & Suites St Joseph
5 out of 5
Posted 13 hours ago
Travelocity Verified Review
"Great place to stay! Will definitely be back."
A verified traveler stayed at Drury Inn & Suites St Joseph
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