Book Hotels in Clarksdale, MO
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Top Clarksdale hotels

Fairfield Inn & Suites by Marriott St. Joseph
4779 Tuscany Drive St. Joseph MO
Fully refundableReserve now, pay when you stay
The price is $123 total per night from Feb 1 to Feb 2
$123 total
per night
Feb 1 - Feb 2
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free ...
Breakfast was very good, Staff was friendly and helpful
Reviewed on Jan 15, 2026

Drury Inn & Suites St Joseph
4213 Frederick Ave St. Joseph MO
Fully refundableReserve now, pay when you stay
The price is $116 total per night from Jan 25 to Jan 26
$116 total
per night
Jan 25 - Jan 26
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
I ALWAYS stay at here when in St. Joseph! The place is super clean and the staff goes above and beyond. Hot breakfast and dinner served every day as well as popcorn and THREE mixed drinks. All included in the daily price. Convenient location.
Reviewed on Jan 19, 2026

My Place Hotel St Joseph MO
3621 N Village Dr St. Joseph MO
Fully refundableReserve now, pay when you stay
The price is $93 total per night from Feb 8 to Feb 9
$93 total
per night
Feb 8 - Feb 9
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the 24-hour business center. ...
It was a clean place to stay.
Reviewed on Jan 17, 2026

Stoney Creek Hotel St. Joseph
1201 N Woobine Rd St. Joseph MO
Fully refundableReserve now, pay when you stay
The price is $117 total per night from Jan 25 to Jan 26
$117 total
per night
Jan 25 - Jan 26
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
Bar offer a good selection making my stay so comfortable
Reviewed on Jan 14, 2026

Red Roof Inn Cameron
501 Northland Drive Cameron MO
Fully refundableReserve now, pay when you stay
The price is $84 total per night from Jan 25 to Jan 26
$84 total
per night
Jan 25 - Jan 26
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like continental breakfast and WiFi ...
Yes. All good.
Reviewed on Jan 17, 2026

SureStay Hotel by Best Western Cameron
2210 US Highway 36 Cameron MO
Fully refundableReserve now, pay when you stay
The price is $77 total per night from Jan 28 to Jan 29
$77 total
per night
Jan 28 - Jan 29
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Staff at the 24-hour front desk can provide ...
Good one night stay experience
Reviewed on Jan 10, 2026

Hampton Inn St. Joseph
3928 Frederick Ave St. Joseph MO
Fully refundableReserve now, pay when you stay
The price is $107 total per night from Jan 25 to Jan 26
$107 total
per night
Jan 25 - Jan 26
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
Nice
Reviewed on Jan 4, 2026

AmeriStay Inn
4502 SE US HWY 169 St. Joseph MO
Fully refundableReserve now, pay when you stay
The price is $99 total per night from Feb 5 to Feb 6
$99 total
per night
Feb 5 - Feb 6
This hotel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free continental breakfast each morning. Express check-out, ...
The staff was amazing and friendly. It is an older hotel, needs a little TLC. But clean and comfortable enough to be a good option.
Reviewed on Nov 25, 2025

Motel 6 Saint Joseph, MO
4021 Frederick Ave St. Joseph MO
Fully refundableReserve now, pay when you stay
The price is $69 total per night from Feb 1 to Feb 2
$69 total
per night
Feb 1 - Feb 2
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. A snack bar/deli and laundry facilities are also provided.
Staff was very nice, very clean, pet friendly. Will definitely stay here again
Reviewed on Dec 22, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Clarksdale hotel reviews by fellow wanderers

Drury Inn & Suites St Joseph
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"I ALWAYS stay at here when in St. Joseph! The place is super clean and the staff goes above and beyond. Hot breakfast and dinner served every day as well as popcorn and THREE mixed drinks. All included in the daily price. Convenient location. "
A verified traveler stayed at Drury Inn & Suites St Joseph
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