Explore top 2025 5 Star Hotels in Otay Mesa West

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Top Otay Mesa West 5 Star hotels

Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street, San Diego, CA
Fully refundableReserve now, pay when you stay
$310 nightly
The price is $360 total per night from Oct 12 to Oct 13
$360 total
Oct 12 - Oct 13
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (1,013 reviews)
"Great! Would stay again"

Reviewed on Sep 22, 2025

Opens in a new windowPendry San Diego
The US Grant, a Luxury Collection Hotel, San Diego

The US Grant, a Luxury Collection Hotel, San Diego

5 out of 5
326 Broadway, San Diego, CA
Fully refundableReserve now, pay when you stay
$278 nightly
The price is $322 total per night from Oct 12 to Oct 13
$322 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...
9/10 Wonderful! (1,003 reviews)
"I can’t say enough wonderful things about our stay at The U.S. Grant! We arrived a bit later than planned for our Thursday night celebration, and yet Manager Kim and the entire team went above and beyond to make it truly special for my wife and me. The food was absolutely delicious, and the service ..."

Reviewed on Sep 22, 2025

Opens in a new windowThe US Grant, a Luxury Collection Hotel, San Diego
The Bower Coronado

The Bower Coronado

5 out of 5
1417 Orange Ave, Coronado, CA
$279 nightly
The price is $302 total per night from Oct 5 to Oct 6
$302 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
9.2/10 Wonderful! (103 reviews)
"Simply a Great place to stay, clean, with friendly staff especially Lamath who was above and beyond in accommodating our needs. We had many walking distance dinning options."

Reviewed on Sep 18, 2025

Opens in a new windowThe Bower Coronado
Beach Village at The Del, LXR Hotels & Resorts

Beach Village at The Del, LXR Hotels & Resorts

5 out of 5
1500 Orange Avenue, Coronado, CA
Fully refundableReserve now, pay when you stay
$783 nightly
The price is $863 total per night from Oct 26 to Oct 27
$863 total
Oct 26 - Oct 27
Total with taxes and fees
A private beach, 7 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy beachfront dining and relax with beach cabanas and sun ...
9/10 Wonderful! (115 reviews)
"X"

Reviewed on Sep 24, 2025

Opens in a new windowBeach Village at The Del, LXR Hotels & Resorts
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