Explore top 2025 4 Star Hotels in Southern Indiana

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Top Southern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$133 nightly
The price is $157 total per night from Nov 25 to Nov 26
$157 total
Nov 25 - Nov 26
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.8/10 Excellent! (3,774 reviews)
Clean room

Reviewed on Nov 16, 2025

Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $234 total per night from Nov 30 to Dec 1
$234 total
Nov 30 - Dec 1
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (1,672 reviews)
Beautiful hotel! So large with so many amenities. Restaurant with really good food, coffee shop, pastries shop, breakfast and lunch sandwich shop and a convenient grocery store. Room was very clean and comfortable and service staff were so friendly and helpful.

Reviewed on Nov 10, 2025

Opens in a new windowOmni Louisville Hotel
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $140 total per night from Nov 26 to Nov 27
$140 total
Nov 26 - Nov 27
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and WiFi in public areas. Valet ...
8.8/10 Excellent! (1,060 reviews)
Great location

Reviewed on Nov 14, 2025

Opens in a new windowEmbassy Suites Louisville Downtown
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $198 total per night from Nov 18 to Nov 19
$198 total
Nov 18 - Nov 19
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.2/10 Wonderful! (1,110 reviews)
Not applicable

Reviewed on Nov 13, 2025

Opens in a new windowThe Brown Hotel
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

4 out of 5
730 E Market St Louisville KY
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Nov 19 to Nov 20
$159 total
Nov 19 - Nov 20
Total with taxes and fees
This hotel features 2 restaurants and 3 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.
9.2/10 Wonderful! (1,004 reviews)
We enjoyed our stay and appreciated the service we received. Every employee was very kind and greeted us warmly. We felt very well taken care of. We will return. Thank you for a wonderful night.

Reviewed on Nov 15, 2025

Opens in a new windowHotel Genevieve part of JdV by Hyatt
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$183 nightly
The price is $216 total per night from Nov 19 to Nov 20
$216 total
Nov 19 - Nov 20
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,003 reviews)
Excellent in every way. The art museum was an added bonus!!!

Reviewed on Nov 15, 2025

Opens in a new window21c Museum Hotel Louisville
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $152 total per night from Nov 19 to Nov 20
$152 total
Nov 19 - Nov 20
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.6/10 Excellent! (1,000 reviews)
Perfectly located in the middle of so many fun things to do. The staff is great, there’s a restaurant, bar and Starbucks inside. We had a great time!

Reviewed on Nov 9, 2025

Opens in a new windowHyatt Regency Louisville
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Fully refundableReserve now, pay when you stay
$188 nightly
The price is $221 total per night from Nov 23 to Nov 24
$221 total
Nov 23 - Nov 24
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
9.2/10 Wonderful! (1,001 reviews)
Nice hotel in a nice location, but not worth the cost.

Reviewed on Nov 13, 2025

Opens in a new windowThe Grady
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $201 total per night from Nov 21 to Nov 22
$201 total
Nov 21 - Nov 22
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,000 reviews)
Room was great, but the service by the attendant that wait on me was exceptional in what she done for me.

Reviewed on Nov 8, 2025

Opens in a new windowLouisville Marriott Downtown
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4 out of 5
101 West Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $206 total per night from Nov 30 to Dec 1
$206 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (423 reviews)
Very modern and comfortable hotel. Great bar and attached restaurant. Location excellent.

Reviewed on Nov 8, 2025

Opens in a new windowHotel Distil, Autograph Collection
Don't see what you're looking for?
See all available properties in Southern Indiana
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Southern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Southern Indiana hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity