Explore top 2026 4 Star Hotels in Southern Indiana

Name: Hotel Distil, Autograph Collection
Price range: $206 total
Rating: 9.6

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Top Southern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$149 nightly

$175 total

Mar 22 - Mar 23

Total with taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9/10 Wonderful! (4,081 reviews)

Helpful staff, easy navigation.

Reviewed on Mar 10, 2026

Omni Louisville Hotel

400 S. 2nd Street Louisville KY

Fully refundableReserve now, pay when you stay

$183 nightly

$216 total

Mar 29 - Mar 30

Total with taxes and fees

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (1,789 reviews)

I was very frusterated with the check-in process and the staff. We booked this hotel to have 2 queen beds and then at check-in which was just before 10pm at night they tried to tell me that they did not have any double queen rooms available and that I was getting switched into a kind room (which ...

Reviewed on Mar 10, 2026

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$115 nightly

$135 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...

9/10 Wonderful! (1,165 reviews)

The location was great! By everything we needed.

Reviewed on Mar 10, 2026

Hotel Genevieve part of JdV by Hyatt

730 E Market St Louisville KY

Fully refundableReserve now, pay when you stay

$135 nightly

$159 total

Mar 18 - Mar 19

Total with taxes and fees

This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.

9.2/10 Wonderful! (1,053 reviews)

Great location. Clean. Friendly staff.

Reviewed on Mar 7, 2026

The Brown Hotel

335 W Broadway Louisville KY

Fully refundableReserve now, pay when you stay

$178 nightly

$210 total

Mar 19 - Mar 20

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

9.4/10 Exceptional! (1,190 reviews)

Second time around for our anniversary. Room wasn’t as nice,but still comfortable. Restaurant bar and servers were great! I’m sure we’ll be back again.

Reviewed on Mar 2, 2026

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$183 nightly

$216 total

Mar 30 - Mar 31

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.4/10 Exceptional! (1,000 reviews)

Lovely hotel. Would stay there again.

Reviewed on Mar 5, 2026

Hyatt Regency Louisville

320 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$133 nightly

$156 total

Apr 5 - Apr 6

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

8.8/10 Excellent! (1,001 reviews)

The hotel overall was a disappointment this time around. Room was not cleaned all the way through small papers on the floor and other small objects on the couch. Woke up early to loud music at 6am and construction/remodeling banging shortly followed.

Reviewed on Mar 10, 2026

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

143 West Market St Louisville KY

Fully refundableReserve now, pay when you stay

$144 nightly

$169 total

Apr 3 - Apr 4

Total with taxes and fees

This smoke-free hotel's 2 restaurants, 3 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (81 reviews)

If you want to sleep don’t stay here. Insanely loud cars race down the street next to the hotel all night. Absolutely insane noise and then the way the room is lighted boggled my mind, all off on one switch it is the switch is on you have to shut them all off except the one under the bed attached ...

Reviewed on Mar 8, 2026

Louisville Marriott Downtown

280 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$168 nightly

$197 total

Apr 5 - Apr 6

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9/10 Wonderful! (1,001 reviews)

Awesome downtown location! Oliver and Hermina were extremely helpfu. Clean and nice rooms! Will definitely stay again!

Reviewed on Mar 10, 2026

Hotel Distil, Autograph Collection

101 West Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$175 nightly

$206 total

Apr 5 - Apr 6

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

9.6/10 Exceptional! (456 reviews)

Great location

Reviewed on Mar 8, 2026

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4 Star Hotels Southern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.