Explore top 2026 4 Star Hotels in Southern Indiana

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Top Southern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $173 total per night from Aug 14 to Aug 15
$173 total
Aug 14 - Aug 15
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $187 total per night from Aug 2 to Aug 3
$187 total
Aug 2 - Aug 3
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
Opens in a new windowOmni Louisville Hotel
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $140 total per night from Aug 6 to Aug 7
$140 total
Aug 6 - Aug 7
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.8/10 Excellent! (1,007 reviews)
"Very nice hotel."

Reviewed on Jul 27, 2026

Opens in a new windowHyatt Regency Louisville
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $184 total per night from Aug 23 to Aug 24
$184 total
Aug 23 - Aug 24
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
Opens in a new window21c Museum Hotel Louisville
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $208 total per night from Aug 4 to Aug 5
$208 total
Aug 4 - Aug 5
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.4/10 Exceptional! (1,285 reviews)
"This is an old-school luxury hotel. The room was massive for what I paid and lots of classy antique decorations and furniture."

Reviewed on Jul 28, 2026

Opens in a new windowThe Brown Hotel
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $207 total per night from Aug 9 to Aug 10
$207 total
Aug 9 - Aug 10
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
9.4/10 Exceptional! (1,015 reviews)
"This hotel is in a perfect spot for walking to distilleries and restaurants. It’s decorated beautifully. The rooms are spacious and also wonderfully decorated. The staff was knowledgeable and friendly."

Reviewed on Jul 27, 2026

Opens in a new windowThe Grady
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $144 total per night from Aug 16 to Aug 17
$144 total
Aug 16 - Aug 17
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
9/10 Wonderful! (1,316 reviews)
"Malísima atención te roban el dinero de tu Targeta hasta por nada calor mucha calor las camas malas"

Reviewed on Jul 28, 2026

Opens in a new windowEmbassy Suites Louisville Downtown
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $197 total per night from Aug 16 to Aug 17
$197 total
Aug 16 - Aug 17
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Opens in a new windowLouisville Marriott Downtown
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

4 out of 5
730 E Market St Louisville KY
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Aug 3 to Aug 4
$159 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.
Opens in a new windowHotel Genevieve part of JdV by Hyatt
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

4 out of 5
143 West Market St Louisville KY
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $207 total per night from Aug 20 to Aug 21
$207 total
Aug 20 - Aug 21
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 3 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the business center, ...
9.4/10 Exceptional! (133 reviews)
"Hello, The hotel is clean and the staff is very nice .the reason for the 3 stars is how loud it is ,you can hear everything outside all night long .and the auto night lights that you can't turn off."

Reviewed on Jul 27, 2026

Opens in a new windowHotel Bourré Bonne Louisville, Curio Collection by Hilton
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4 Star Hotels Southern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Southern Indiana hotel reviews by fellow wanderers

Santas Lodge and Resort

Santas Lodge and Resort

5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"The staff were great! A perfect place to stay after spending the day at Holiday World!"
A verified traveler stayed at Santas Lodge and Resort
Santas Lodge and Resort

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