Explore top 2026 4 Star Hotels in Southern Indiana

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Top Southern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $158 total per night from Jan 28 to Jan 29
$158 total
Jan 28 - Jan 29
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.8/10 Excellent! (3,999 reviews)
The breakfast was delicious, the staff was amazing to be with and supper attended.

Reviewed on Jan 20, 2026

Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $197 total per night from Jan 23 to Jan 24
$197 total
Jan 23 - Jan 24
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (1,761 reviews)
Stayed NYE. Moderately priced much to our surprise. Our group had a fantastic dinner @ Bobs. Highly recommend. Will be back!

Reviewed on Jan 16, 2026

Opens in a new windowOmni Louisville Hotel
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $144 total per night from Feb 8 to Feb 9
$144 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
8.8/10 Excellent! (1,140 reviews)
Great staff, Clean comfortable rooms. Convenient for our purpose. Great breakfast.

Reviewed on Jan 9, 2026

Opens in a new windowEmbassy Suites Louisville Downtown
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $198 total per night from Jan 23 to Jan 24
$198 total
Jan 23 - Jan 24
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.2/10 Wonderful! (1,167 reviews)
Staff was incredibly kind and helpful. Hotel is beautiful!

Reviewed on Jan 11, 2026

Opens in a new windowThe Brown Hotel
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

4 out of 5
730 E Market St Louisville KY
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $139 total per night from Jan 28 to Jan 29
$139 total
Jan 28 - Jan 29
Total with taxes and fees
This hotel features 2 restaurants and 3 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.
9.2/10 Wonderful! (1,034 reviews)
We loved our stay for a quick getaway. We arrived on a Sunday. Our only wish was that the market and coffee shop were open for a snack before dinner. Other than that it was wonderful!

Reviewed on Jan 20, 2026

Opens in a new windowHotel Genevieve part of JdV by Hyatt
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$145 nightly
The price is $170 total per night from Jan 25 to Jan 26
$170 total
Jan 25 - Jan 26
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,000 reviews)
Staff very helpful. Rooms are spacious and clean. Lobby exhibits unique and interesting. Hotel well situated in downtown to access popular tourist attractions. Enjoyed our stay.

Reviewed on Jan 20, 2026

Opens in a new window21c Museum Hotel Louisville
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Jan 31 to Feb 1
$159 total
Jan 31 - Feb 1
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.6/10 Excellent! (1,002 reviews)
This is our second time staying at this hotel. The service is great and the rooms are clean. It's close to everything. I would stay here again.

Reviewed on Jan 19, 2026

Opens in a new windowHyatt Regency Louisville
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $189 total per night from Feb 1 to Feb 2
$189 total
Feb 1 - Feb 2
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
9.4/10 Exceptional! (1,005 reviews)
The Grady was wonderful. Staff was friendly, the hotel was clean and charming. We will definitely be returning to the Grady in the future.

Reviewed on Jan 20, 2026

Opens in a new windowThe Grady
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$180 nightly
The price is $211 total per night from Feb 8 to Feb 9
$211 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,003 reviews)
Room was spotless. Staff was top notch. Amenities as expected but I did expect a microwave in the room. There wasn't one. 9/10 experience. Will definitely book again!

Reviewed on Jan 16, 2026

Opens in a new windowLouisville Marriott Downtown
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4 out of 5
101 West Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $216 total per night from Feb 8 to Feb 9
$216 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (435 reviews)
Clean, well appointed, convenient to restaurants and downtown Louisville.

Reviewed on Jan 3, 2026

Opens in a new windowHotel Distil, Autograph Collection
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4 Star Hotels Southern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Southern Indiana hotel reviews by fellow wanderers

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