Explore top 2026 4 Star Hotels in Southern Indiana

Name: Hotel Distil, Autograph Collection
Price range: $216 total
Rating: 9.4

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Top Southern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$134 nightly

$158 total

Jan 28 - Jan 29

Total with taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

8.8/10 Excellent! (3,999 reviews)

The breakfast was delicious, the staff was amazing to be with and supper attended.

Reviewed on Jan 20, 2026

Omni Louisville Hotel

400 S. 2nd Street Louisville KY

Fully refundableReserve now, pay when you stay

$167 nightly

$197 total

Jan 23 - Jan 24

Total with taxes and fees

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.2/10 Wonderful! (1,761 reviews)

Stayed NYE. Moderately priced much to our surprise. Our group had a fantastic dinner @ Bobs. Highly recommend. Will be back!

Reviewed on Jan 16, 2026

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$122 nightly

$144 total

Feb 8 - Feb 9

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...

8.8/10 Excellent! (1,140 reviews)

Great staff, Clean comfortable rooms. Convenient for our purpose. Great breakfast.

Reviewed on Jan 9, 2026

The Brown Hotel

335 W Broadway Louisville KY

Fully refundableReserve now, pay when you stay

$168 nightly

$198 total

Jan 23 - Jan 24

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

9.2/10 Wonderful! (1,167 reviews)

Staff was incredibly kind and helpful. Hotel is beautiful!

Reviewed on Jan 11, 2026

Hotel Genevieve part of JdV by Hyatt

730 E Market St Louisville KY

Fully refundableReserve now, pay when you stay

$118 nightly

$139 total

Jan 28 - Jan 29

Total with taxes and fees

This hotel features 2 restaurants and 3 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.

9.2/10 Wonderful! (1,034 reviews)

We loved our stay for a quick getaway. We arrived on a Sunday. Our only wish was that the market and coffee shop were open for a snack before dinner. Other than that it was wonderful!

Reviewed on Jan 20, 2026

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$145 nightly

$170 total

Jan 25 - Jan 26

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.2/10 Wonderful! (1,000 reviews)

Staff very helpful. Rooms are spacious and clean. Lobby exhibits unique and interesting. Hotel well situated in downtown to access popular tourist attractions. Enjoyed our stay.

Reviewed on Jan 20, 2026

Hyatt Regency Louisville

320 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$135 nightly

$159 total

Jan 31 - Feb 1

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

8.6/10 Excellent! (1,002 reviews)

This is our second time staying at this hotel. The service is great and the rooms are clean. It's close to everything. I would stay here again.

Reviewed on Jan 19, 2026

The Grady

601 W Main St Louisville KY

Fully refundableReserve now, pay when you stay

$161 nightly

$189 total

Feb 1 - Feb 2

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.

9.4/10 Exceptional! (1,005 reviews)

The Grady was wonderful. Staff was friendly, the hotel was clean and charming. We will definitely be returning to the Grady in the future.

Reviewed on Jan 20, 2026

Louisville Marriott Downtown

280 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$180 nightly

$211 total

Feb 8 - Feb 9

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9/10 Wonderful! (1,003 reviews)

Room was spotless. Staff was top notch. Amenities as expected but I did expect a microwave in the room. There wasn't one. 9/10 experience. Will definitely book again!

Reviewed on Jan 16, 2026

Hotel Distil, Autograph Collection

101 West Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$184 nightly

$216 total

Feb 8 - Feb 9

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

9.4/10 Exceptional! (435 reviews)

Clean, well appointed, convenient to restaurants and downtown Louisville.

Reviewed on Jan 3, 2026

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4 Star Hotels Southern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.