Explore top 2026 4 Star Hotels in Southern Indiana

Name: Hotel Distil, Autograph Collection
Price range: $279 total

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Top Southern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$162 nightly

$191 total

Oct 4 - Oct 5

Total with taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9/10 Wonderful! (4,289 reviews)

"Great properly in a great location!"

Reviewed on Sep 15, 2026

Omni Louisville Hotel

400 S. 2nd Street Louisville KY

Fully refundableReserve now, pay when you stay

$279 nightly

$329 total

Sep 30 - Oct 1

Total with taxes and fees

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

The Brown Hotel

335 W Broadway Louisville KY

Fully refundableReserve now, pay when you stay

$161 nightly

$189 total

Sep 20 - Sep 21

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

9.4/10 Exceptional! (1,305 reviews)

"Really enjoyed our stay here and the historical look of the hotel."

Reviewed on Sep 14, 2026

Hyatt Regency Louisville

320 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$182 nightly

$214 total

Oct 4 - Oct 5

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$163 nightly

$192 total

Oct 11 - Oct 12

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...

9/10 Wonderful! (1,361 reviews)

"Great location! Breakfast was better than expected with an omelette station. Loved the convenience of the airport shuttle. Only complaint was where the TV was on the wall and the position of the bed."

Reviewed on Sep 13, 2026

Hotel Genevieve part of JdV by Hyatt

730 E Market St Louisville KY

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Oct 4 - Oct 5

Total with taxes and fees

This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.

9.2/10 Wonderful! (1,100 reviews)

"I liked the staff. They were responsive and friendly. The management was quick to respect my concerns and find an amenable solution."

Reviewed on Sep 14, 2026

Louisville Marriott Downtown

280 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$214 nightly

$252 total

Oct 4 - Oct 5

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9/10 Wonderful! (1,000 reviews)

"The staff was amazing and the hotel was very nice and clean however, the biggest issues was the hotel was incredibly hot everywhere! The ladies restrooms were like saunas and it was difficult to maintain a decent temperature. The hotel really needs to address the temperature issues."

Reviewed on Sep 14, 2026

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$183 nightly

$216 total

Sep 20 - Sep 21

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.4/10 Exceptional! (1,003 reviews)

"Mini fridge in room is full of paid items. No room to store any left overs or drinks. Otherwise everything was very nice. Clean room and rr, water pressure was great, museum was a nice spot to wander around and learn a bit. Easy in and out."

Reviewed on Sep 14, 2026

The Grady

601 W Main St Louisville KY

$198 nightly

$233 total

Oct 11 - Oct 12

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.

Hotel Distil, Autograph Collection

101 West Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$237 nightly

$279 total

Oct 11 - Oct 12

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

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4 Star Hotels Southern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Southern Indiana hotel reviews by fellow wanderers

Derby Hotel & Suites

4 out of 5

Posted 13 hours ago

Travelocity Verified Review

"There is only 1 community microwave by the lobby. They claim to be a 100% non smoking hotel but our room smelled like cigarettes each time we went inside. The ac would cut on and off at random times(no it wasn’t on eco)"

A verified traveler stayed at Derby Hotel & Suites