Explore top 2026 4 Star Hotels in Southern Indiana

Name: Hotel Genevieve part of JdV by Hyatt
Price range: $168 total

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Top Southern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$136 nightly

$160 total

Nov 15 - Nov 16

Total with taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

The Brown Hotel

335 W Broadway Louisville KY

Fully refundableReserve now, pay when you stay

$130 nightly

$153 total

Nov 25 - Nov 26

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

Omni Louisville Hotel

400 S. 2nd Street Louisville KY

Fully refundableReserve now, pay when you stay

$131 nightly

$155 total

Nov 6 - Nov 7

Total with taxes and fees

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

Louisville Marriott Downtown

280 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$117 nightly

$138 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

Hyatt Regency Louisville

320 West Jefferson Street Louisville KY

Fully refundableReserve now, pay when you stay

$125 nightly

$147 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$130 nightly

$153 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...

The Grady

601 W Main St Louisville KY

Fully refundableReserve now, pay when you stay

$173 nightly

$204 total

Nov 15 - Nov 16

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.

9.4/10 Exceptional! (1,006 reviews)

"Property and location are outstanding. The wild swan restaurant is amazing and if you have the chance to meet Mark, you get the history of the hotel and get to have the service you would want. Mark was fantastic and was the highlight of the hotel for us. Everything is spotless and clean. Great service ..."

Reviewed on Nov 4, 2026

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$165 nightly

$194 total

Nov 29 - Nov 30

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.4/10 Exceptional! (1,001 reviews)

"Nice room. It was very clean and comfortable."

Reviewed on Nov 4, 2026

Hotel Distil, Autograph Collection

101 West Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$202 nightly

$237 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

Hotel Genevieve part of JdV by Hyatt

730 E Market St Louisville KY

Fully refundableReserve now, pay when you stay

$143 nightly

$168 total

Nov 8 - Nov 9

Total with taxes and fees

This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Southern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.