Explore 41 Luxury Hotels in Southern Indiana

Name: Baymont by Wyndham Corydon
Price range: $83 total
Rating: 7.6

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Best Luxury Hotels in Southern Indiana

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$194 total

per night

May 10 - May 11

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.4/10 Exceptional! (1,003 reviews)

I'm conflicted about this hotel. One the one hand, it's very stylish and looks modern. The art is a nice touch. The rooms are comfortable. Staff is nice. But ... what a terrible night. The walls are paper thin. Heard our neighbors use the bathroom, make love, moan, listen to their TVs. Had such a ...

Reviewed on Apr 8, 2026

The Brown Hotel

335 W Broadway Louisville KY

Fully refundableReserve now, pay when you stay

$192 total

per night

Apr 13 - Apr 14

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

9.4/10 Exceptional! (1,173 reviews)

One of my favorite places to stay.

Reviewed on Apr 11, 2026

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$211 total

per night

Apr 19 - Apr 20

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9/10 Wonderful! (4,150 reviews)

Clean room. Nice staff. Brought up a crib

Reviewed on Apr 11, 2026

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$162 total

per night

May 4 - May 5

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...

9/10 Wonderful! (1,189 reviews)

I have stayed before with very pleasant stays. This time they were short staffed making this last stay not as pleasurable. Hopefully they can manage to get more staffing. Breakfast was good, parking we used valet.

Reviewed on Apr 10, 2026

Seelbach Hilton Louisville Downtown

500 S 4th St Louisville KY

Fully refundableReserve now, pay when you stay

$198 total

per night

May 4 - May 5

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...

8.6/10 Excellent! (1,001 reviews)

Great experience overall but woild have loved to explore the closed areas that make the Seelbach famous.

Reviewed on Apr 2, 2026

Baymont by Wyndham Corydon

2495 Landmark Avenue NE Corydon IN

Fully refundableReserve now, pay when you stay

$83 total

per night

Apr 26 - Apr 27

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...

7.6/10 Good! (1,000 reviews)

The room was ok. It had a weird smell. I stayed because I was there for one night if I was there longer would've went somewhere else.

Reviewed on Apr 2, 2026

Econo Lodge Louisville Downtown

401 S 2nd St Louisville KY

Fully refundableReserve now, pay when you stay

$79 total

per night

Apr 26 - Apr 27

This motel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the express check-out. ...

7.2/10 Good! (1,003 reviews)

You’re the most part the hotel was fine. The bed was super uncomfortable and you had to pay to stay there not just the room you had to pay to park there to stay there. Also there was a long hair that belonged to somebody else in the shower in Plainview.

Reviewed on Apr 6, 2026

West Baden Springs Hotel

8538 W Baden Ave West Baden Springs IN

This luxury resort features a casino, a full-service spa, and 15 restaurants. Bring the family and enjoy the children's club, along with horse riding/rentals. ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Southern Indiana

The Pepin Mansion Historic B&B

1003 E. Main St. New Albany IN

$84 nightly

$95 total

Apr 13 - Apr 14

Total with taxes and fees

9.8/10 Exceptional! (680 reviews)

Southern Indiana Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southern Indiana luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southern Indiana to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southern Indiana will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southern Indiana, and plan your next opulent escape.

Southern Indiana hotels essential information

Accommodation	1,605 hotels
Lowest Price	$79
Highest Price	$264
Popular hotels	21c Museum Hotel Louisville, West Baden Springs Hotel, The Brown Hotel, Galt House Hotel Trademark Collection by Wyndham, Embassy Suites Louisville Downtown, Econo Lodge Louisville Downtown, Seelbach Hilton Louisville Downtown, Baymont by Wyndham Corydon