Explore 41 Luxury Hotels in Southern Indiana

Name: Baymont by Wyndham Corydon
Price range: $75 total
Rating: 7.6

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Best Luxury Hotels in Southern Indiana

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$183 nightly

$216 total

Feb 27 - Feb 28

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.4/10 Exceptional! (1,002 reviews)

clean rooms, outgoing and friendly staff. The vibe is warm and fun, love the penguins

Reviewed on Feb 25, 2026

The Brown Hotel

335 W Broadway Louisville KY

$178 nightly

$210 total

Mar 19 - Mar 20

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

9.4/10 Exceptional! (1,203 reviews)

This is an amazing hotel. Will visit sgsin.

Reviewed on Feb 25, 2026

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$149 nightly

$176 total

Mar 22 - Mar 23

Total with taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9/10 Wonderful! (4,069 reviews)

Wonderful as always

Reviewed on Feb 25, 2026

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$115 nightly

$135 total

Mar 8 - Mar 9

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...

9/10 Wonderful! (1,168 reviews)

The room was excellent

Reviewed on Feb 25, 2026

Seelbach Hilton Louisville Downtown

500 S 4th St Louisville KY

Fully refundableReserve now, pay when you stay

$148 nightly

$174 total

Mar 15 - Mar 16

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...

8.6/10 Excellent! (1,001 reviews)

Fun and historical, great location!

Reviewed on Feb 18, 2026

Baymont by Wyndham Corydon

2495 Landmark Avenue NE Corydon IN

Fully refundableReserve now, pay when you stay

$68 nightly

$75 total

Mar 3 - Mar 4

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...

7.6/10 Good! (1,003 reviews)

Staff is very friendly. Water pressure is excellent. Breakfast and coffee provided the next morning.

Reviewed on Feb 19, 2026

Econo Lodge Louisville Downtown

401 S 2nd St Louisville KY

Fully refundableReserve now, pay when you stay

$67 nightly

$79 total

Mar 10 - Mar 11

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the express check-out. ...

7.2/10 Good! (1,001 reviews)

Front desk staff was very nice, helpful and polite. The water was scalding hot but the shower knob was a bit janky. The bed wasn’t ideal but did the job. Room was pretty clean. Overall the place was fine and while convenient, the location was awful; the surrounding noise level was the opposite of ...

Reviewed on Feb 23, 2026

West Baden Springs Hotel

8538 W Baden Ave West Baden Springs IN

This luxury resort features a casino, a full-service spa, and 15 restaurants. Bring the family and enjoy the children's club, along with horse riding/rentals. ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Southern Indiana

The Pepin Mansion Historic B&B

1003 E. Main St. New Albany IN

$94 nightly

$106 total

Feb 26 - Feb 27

Total with taxes and fees

9.8/10 Exceptional! (667 reviews)

Southern Indiana Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southern Indiana luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southern Indiana to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southern Indiana will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southern Indiana, and plan your next opulent escape.

Southern Indiana hotels essential information

Accommodation	1,630 hotels
Lowest Price	$75
Highest Price	$235
Popular hotels	21c Museum Hotel Louisville, West Baden Springs Hotel, The Brown Hotel, Galt House Hotel Trademark Collection by Wyndham, Embassy Suites Louisville Downtown, Econo Lodge Louisville Downtown, Seelbach Hilton Louisville Downtown, Baymont by Wyndham Corydon