Explore 41 Luxury Hotels in Southern Indiana
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Best Luxury Hotels in Southern Indiana
21c Museum Hotel Louisville
"Unique and fun place to stay. Loved the art works displayed throughout the property. Appreciated the sense of humor with the red penguins that surprised us appearing at different locations every day. Staff was professional and friendly. Small fridge in the room would have been nice."
Reviewed on Oct 13, 2026
Embassy Suites Louisville Downtown
"Leading up to the trip communication was amazing. I thought the staff at the desk was pleasant & helpful. And the hotel is beautiful & clean. Our only complaint was the shuttle. We followed the information provided for using it & were told upon arrival at the airport that we would need to wait as ..."
Reviewed on Oct 11, 2026
Seelbach Hilton Louisville Downtown
"Lovely 100+ years old place right in downtown. Big bathroom with great shower and lovely thick towels. Lots of room in the room--comfy beds, plenty of pillows, nice desk, plenty of outlets. Coffee, tea, complimentary water."
Reviewed on Oct 9, 2026
Econo Lodge Louisville Downtown
"This is the second time I have stayed here. Very clean. The hairdryer in room stopped working and I called the front desk. I was very impressed by how fast they came to my room and took care of my needs. A+. Also, the room was Very clean. Great housekeeping. The only complaint I had was the vending ..."
Reviewed on Oct 12, 2026
West Baden Springs Hotel
The Brown Hotel
Galt House Hotel Trademark Collection by Wyndham
Baymont by Wyndham Corydon
More 4 star hotels in Southern Indiana
The Pepin Mansion Historic B&B
Southern Indiana Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southern Indiana luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Southern Indiana to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Southern Indiana will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southern Indiana, and plan your next opulent escape.
Southern Indiana hotels essential information
Accommodation | 1,631 hotels |
|---|---|
Lowest Price | $79 |
Highest Price | $238 |
Popular hotels | 21c Museum Hotel Louisville, West Baden Springs Hotel, The Brown Hotel, Galt House Hotel Trademark Collection by Wyndham, Embassy Suites Louisville Downtown, Econo Lodge Louisville Downtown, Seelbach Hilton Louisville Downtown, Baymont by Wyndham Corydon |
Popular Luxury Stays in Southern Indiana
Recent Southern Indiana Hotel Reviews By Fellow Wanderers
Hampton Inn New Albany Louisville West
"Front desk girl could put a smile on anybody’s face"