Explore 41 Luxury Hotels in Southern Indiana

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Best Luxury Hotels in Southern Indiana

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$183 nightly

$216 total

Nov 19 - Nov 20

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.2/10 Wonderful! (1,003 reviews)

Excellent in every way. The art museum was an added bonus!!!

Reviewed on Nov 15, 2025

The Brown Hotel

335 W Broadway Louisville KY

Fully refundableReserve now, pay when you stay

$118 nightly

$139 total

Dec 2 - Dec 3

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

9.2/10 Wonderful! (1,110 reviews)

Not applicable

Reviewed on Nov 13, 2025

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$105 nightly

$123 total

Dec 2 - Dec 3

Total with taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

8.8/10 Excellent! (3,774 reviews)

Clean room

Reviewed on Nov 16, 2025

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$119 nightly

$140 total

Nov 24 - Nov 25

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and WiFi in public areas. Valet ...

8.8/10 Excellent! (1,060 reviews)

Great location

Reviewed on Nov 14, 2025

Seelbach Hilton Louisville Downtown

500 S 4th St Louisville KY

Fully refundableReserve now, pay when you stay

$127 nightly

$149 total

Nov 26 - Nov 27

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...

8.6/10 Excellent! (1,001 reviews)

Spacious room in a quiet place in the hotel. The property is a little dated, but if you prefer history, friendly people and an exception bar, then this is a great property.

Reviewed on Nov 12, 2025

Baymont by Wyndham Corydon

2495 Landmark Avenue NE, Corydon, IN

Fully refundableReserve now, pay when you stay

$69 nightly

$76 total

Dec 14 - Dec 15

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...

7.4/10 Good! (1,004 reviews)

Was great.bed hard.breakfast nice have fruits.it work for is.

Reviewed on Nov 16, 2025

Econo Lodge Louisville Downtown

401 S 2nd St Louisville KY

Fully refundableReserve now, pay when you stay

$62 nightly

$73 total

Dec 4 - Dec 5

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the express check-out. ...

7/10 Good! (1,004 reviews)

The location was great , the rates were fair . Overall it was a great place to stay ! Thanks !

Reviewed on Nov 16, 2025

West Baden Springs Hotel

8538 W Baden Ave West Baden Springs IN

This luxury resort features a casino, a full-service spa, and 15 restaurants. Bring the family and enjoy the children's club, along with horse riding/rentals. ...

The hotel West Baden is awesome they have 24 hour trolley that runs every 15 minutes and will take you anywhere in the area.

Reviewed on Dec 25, 2018

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Southern Indiana

Stellar Suites

822 E Market St Louisville KY

$154 nightly

$179 total

Dec 7 - Dec 8

Total with taxes and fees

9.6/10 Exceptional! (113 reviews)

Southern Indiana Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southern Indiana luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southern Indiana to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southern Indiana will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southern Indiana, and plan your next opulent escape.

Southern Indiana hotels essential information

Accommodation	1,583 hotels
Lowest Price	$73
Highest Price	$216
Popular hotels	21c Museum Hotel Louisville, West Baden Springs Hotel, The Brown Hotel, Galt House Hotel Trademark Collection by Wyndham, Embassy Suites Louisville Downtown, Econo Lodge Louisville Downtown, Seelbach Hilton Louisville Downtown, Baymont by Wyndham Corydon