Explore 41 Luxury Hotels in Southern Indiana

Name: Baymont by Wyndham Corydon
Price range: $96 total
Rating: 7.6

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Best Luxury Hotels in Southern Indiana

21c Museum Hotel Louisville

700 W Main Street Louisville KY

Fully refundableReserve now, pay when you stay

$156 nightly

$184 total

Jun 21 - Jun 22

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.4/10 Exceptional! (1,001 reviews)

"Hotel was wonderful - unfortunately our vehicle was broken into in the parking garage but the hotel staff helped us clean up the glass and cover the window and took a report. Bar staff was super fun and friendly and loved the overall vibe."

Reviewed on May 11, 2026

The Brown Hotel

335 W Broadway Louisville KY

Fully refundableReserve now, pay when you stay

$163 nightly

$192 total

Jun 28 - Jun 29

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...

9.4/10 Exceptional! (1,231 reviews)

"The Hotel it's self is beautiful inside. The outside needs some up keep. The main dining area had a very strong musty smell couldn't eat in there. Had a chef table experience, nice service but way over priced."

Reviewed on May 27, 2026

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$144 nightly

$170 total

Jun 7 - Jun 8

Total with taxes and fees

A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...

9/10 Wonderful! (4,173 reviews)

"The Galt Hotel was a lovely place to stay during our trip for a family event. I traveled with my child, and overall we had a great experience. Upon arrival, the valet area was a bit confusing. The staff seemed to wait for us rather than approaching the vehicle to assist with check-in, but perhaps ..."

Reviewed on May 28, 2026

Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

Fully refundableReserve now, pay when you stay

$106 nightly

$124 total

Jun 14 - Jun 15

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...

9/10 Wonderful! (1,251 reviews)

"The property looks great at first glance, but was super hot in the hallways and walls and carpets dirty. My room when went to lay down had mold on sheets cakes it was like 1a and they threw new sheets in car at me didn't offer to make the bed and I mentioned it was hot had to game security come at ..."

Reviewed on May 26, 2026

Seelbach Hilton Louisville Downtown

500 S 4th St Louisville KY

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Jun 4 - Jun 5

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...

8.6/10 Excellent! (1,001 reviews)

"Had to ask for a room service menu which came on a door hanger Shortage of baggage carts Closet hangers only had lower row No place to hang long dresses, outdated tub and shower combo Dropoff at front of hotel overwhelmed by two weddings with deliveries and guests trying to valet park - told it was ..."

Reviewed on May 27, 2026

Baymont by Wyndham Corydon

2495 Landmark Avenue NE Corydon IN

Fully refundableReserve now, pay when you stay

$87 nightly

$96 total

Jun 6 - Jun 7

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...

7.6/10 Good! (1,002 reviews)

"Everything was great"

Reviewed on May 25, 2026

Econo Lodge Louisville Downtown

401 S 2nd St Louisville KY

Fully refundableReserve now, pay when you stay

$67 nightly

$79 total

Jun 10 - Jun 11

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the express check-out. ...

7.2/10 Good! (1,003 reviews)

"Good stay and location. Easy access to my destinations."

Reviewed on May 28, 2026

West Baden Springs Hotel

8538 W Baden Ave West Baden Springs IN

This luxury resort features a casino, a full-service spa, and 15 restaurants. Bring the family and enjoy the children's club, along with horse riding/rentals. ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Southern Indiana

stayAPT Suites Louisville North-Clarksville

1628 Leisure Way Clarksville IN

$149 nightly

$168 total

May 29 - May 30

Total with taxes and fees

9.8/10 Exceptional! (49 reviews)

Southern Indiana Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southern Indiana luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southern Indiana to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southern Indiana will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southern Indiana, and plan your next opulent escape.

Southern Indiana hotels essential information

Accommodation	1,627 hotels
Lowest Price	$79
Highest Price	$242
Popular hotels	21c Museum Hotel Louisville, West Baden Springs Hotel, The Brown Hotel, Galt House Hotel Trademark Collection by Wyndham, Embassy Suites Louisville Downtown, Econo Lodge Louisville Downtown, Seelbach Hilton Louisville Downtown, Baymont by Wyndham Corydon

Popular Luxury Stays in Southern Indiana

5 Stars Luxury stays in Southern Indiana

Luxury stays in Southern Indiana with spa

Recent Southern Indiana Hotel Reviews By Fellow Wanderers

Hampton Inn New Albany Louisville West

3 out of 5

Posted less than an hour ago

Travelocity Verified Review

"You get what you pay for. Not in the very best area, but not so sketchy that you're terrified to walk in. Pulled into the parking lot and got hit with a strong smell of marijuana in the parking lot (obviously not the hotel's fault). Most of the parking is behind the building, and I was a little too worried that late night to park back there and have to walk around alone. I ended up parking in the raggedy building right next to it's parking lot. I had a pretty late check-in (around 11PM) and the night staff was nice enough and provided an easy check-in. The room was clean enough, but it could use a couple repairs. The biggest issue I had was the crack in the ceiling of my bathroom leaking down on me and dropping water on my head/back while I was trying to use the toilet. A few rough patches on walls and the bathroom door could have used a freshen up. The breakfast was actually quite good, along with the coffee. Not a terrible experience for only a $100 in a King Bed room, but not something I'd go to for a vacation. Thankfully I was just there for a quick sleep on a work trip. Morning staff at check out was pleasant also."

A verified traveler stayed at Hampton Inn New Albany Louisville West