Explore 41 Luxury Hotels in Southern Indiana
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Best Luxury Hotels in Southern Indiana

21c Museum Hotel Louisville
"Hotel was wonderful - unfortunately our vehicle was broken into in the parking garage but the hotel staff helped us clean up the glass and cover the window and took a report. Bar staff was super fun and friendly and loved the overall vibe."
Reviewed on May 11, 2026

The Brown Hotel
"The Hotel it's self is beautiful inside. The outside needs some up keep. The main dining area had a very strong musty smell couldn't eat in there. Had a chef table experience, nice service but way over priced."
Reviewed on May 27, 2026

Galt House Hotel Trademark Collection by Wyndham
"The Galt Hotel was a lovely place to stay during our trip for a family event. I traveled with my child, and overall we had a great experience. Upon arrival, the valet area was a bit confusing. The staff seemed to wait for us rather than approaching the vehicle to assist with check-in, but perhaps ..."
Reviewed on May 28, 2026

Embassy Suites Louisville Downtown
"The property looks great at first glance, but was super hot in the hallways and walls and carpets dirty. My room when went to lay down had mold on sheets cakes it was like 1a and they threw new sheets in car at me didn't offer to make the bed and I mentioned it was hot had to game security come at ..."
Reviewed on May 26, 2026

Seelbach Hilton Louisville Downtown
"Had to ask for a room service menu which came on a door hanger Shortage of baggage carts Closet hangers only had lower row No place to hang long dresses, outdated tub and shower combo Dropoff at front of hotel overwhelmed by two weddings with deliveries and guests trying to valet park - told it was ..."
Reviewed on May 27, 2026

Baymont by Wyndham Corydon
"Everything was great"
Reviewed on May 25, 2026

Econo Lodge Louisville Downtown
"Good stay and location. Easy access to my destinations."
Reviewed on May 28, 2026

West Baden Springs Hotel
More 4 star hotels in Southern Indiana

stayAPT Suites Louisville North-Clarksville
Southern Indiana Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southern Indiana luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Southern Indiana to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Southern Indiana will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southern Indiana, and plan your next opulent escape.
Southern Indiana hotels essential information
Accommodation | 1,627 hotels |
|---|---|
Lowest Price | $79 |
Highest Price | $242 |
Popular hotels | 21c Museum Hotel Louisville, West Baden Springs Hotel, The Brown Hotel, Galt House Hotel Trademark Collection by Wyndham, Embassy Suites Louisville Downtown, Econo Lodge Louisville Downtown, Seelbach Hilton Louisville Downtown, Baymont by Wyndham Corydon |
Popular Luxury Stays in Southern Indiana
Recent Southern Indiana Hotel Reviews By Fellow Wanderers

Hampton Inn New Albany Louisville West
"You get what you pay for. Not in the very best area, but not so sketchy that you're terrified to walk in. Pulled into the parking lot and got hit with a strong smell of marijuana in the parking lot (obviously not the hotel's fault). Most of the parking is behind the building, and I was a little too worried that late night to park back there and have to walk around alone. I ended up parking in the raggedy building right next to it's parking lot. I had a pretty late check-in (around 11PM) and the night staff was nice enough and provided an easy check-in. The room was clean enough, but it could use a couple repairs. The biggest issue I had was the crack in the ceiling of my bathroom leaking down on me and dropping water on my head/back while I was trying to use the toilet. A few rough patches on walls and the bathroom door could have used a freshen up. The breakfast was actually quite good, along with the coffee. Not a terrible experience for only a $100 in a King Bed room, but not something I'd go to for a vacation. Thankfully I was just there for a quick sleep on a work trip. Morning staff at check out was pleasant also."
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