Explore top 2026 4 Star Hotels in Southeastern Indiana

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Top Southeastern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $173 total per night from Aug 3 to Aug 4
$173 total
Aug 3 - Aug 4
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9/10 Wonderful! (4,150 reviews)
"The front desk staff was amazing. I stayed in the West Tower and the room was very nice. The only issue we had was the restaurant Walker's Exchange wasn't open. I wanted a Kentucky Hotbrown so that was disappointing."

Reviewed on Jul 4, 2026

Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $187 total per night from Jul 6 to Jul 7
$187 total
Jul 6 - Jul 7
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.4/10 Exceptional! (1,965 reviews)
"The hotel was very nice and clean. There was an upscale food court. The pool area was very nice. The hotel was in a great location to Whiskey Row, casino and multiple restaurants and Bars."

Reviewed on Jul 4, 2026

Opens in a new windowOmni Louisville Hotel
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $184 total per night from Jul 26 to Jul 27
$184 total
Jul 26 - Jul 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.4/10 Exceptional! (1,002 reviews)
"I’ve always wanted to stay in a 21C hotel and I am glad I made the decision to in Louisville. Not only was the art awe inspiring, but the hotel and its staff were amazing. They were very accommodating, everything was clean and cute, and they even give you a free nightcap shot of bourbon. The location ..."

Reviewed on Jun 30, 2026

Opens in a new window21c Museum Hotel Louisville
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $144 total per night from Jul 27 to Jul 28
$144 total
Jul 27 - Jul 28
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
9/10 Wonderful! (1,286 reviews)
"Everything was clean and well kept"

Reviewed on Jul 4, 2026

Opens in a new windowEmbassy Suites Louisville Downtown
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $169 total per night from Aug 1 to Aug 2
$169 total
Aug 1 - Aug 2
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.8/10 Excellent! (1,002 reviews)
"Very nice clean hotel, staff was nice property was beautiful. I enjoyed my stay and love being around all the activities n restaurants close by."

Reviewed on Jul 3, 2026

Opens in a new windowHyatt Regency Louisville
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $197 total per night from Aug 2 to Aug 3
$197 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,001 reviews)
"Beautiful hotel"

Reviewed on Jul 1, 2026

Opens in a new windowLouisville Marriott Downtown
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $206 total per night from Jul 6 to Jul 7
$206 total
Jul 6 - Jul 7
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
9.4/10 Exceptional! (1,003 reviews)
"Excellent hotel with a great restaurant which adds to the experience and ambience. Feels more like a small apartment than a hotel room. Very home like feeling and very comfortable bed."

Reviewed on Jul 3, 2026

Opens in a new windowThe Grady
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

4 out of 5
143 West Market St Louisville KY
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $202 total per night from Aug 2 to Aug 3
$202 total
Aug 2 - Aug 3
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 3 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the business center, ...
9.4/10 Exceptional! (122 reviews)
"Only thing I didn’t like is when you order at the pool and pay with cash they don’t have change."

Reviewed on Jul 4, 2026

Opens in a new windowHotel Bourré Bonne Louisville, Curio Collection by Hilton
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4 out of 5
101 West Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$202 nightly
The price is $237 total per night from Aug 2 to Aug 3
$237 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.6/10 Exceptional! (477 reviews)
"We had a wonderful stay at the Hotel Distil in Louisville. From the moment we arrived, the staff was exceptionally polite, welcoming, and always willing to help with anything we needed. Our room was spotless, very comfortable, and offered a beautiful view of the river, making our stay even more enjoyable. ..."

Reviewed on Jun 30, 2026

Opens in a new windowHotel Distil, Autograph Collection
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $201 total per night from Aug 4 to Aug 5
$201 total
Aug 4 - Aug 5
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.4/10 Exceptional! (1,264 reviews)
"The Brown is one of our favorite places to stay when downtown Louisville"

Reviewed on Jul 4, 2026

Opens in a new windowThe Brown Hotel
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4 Star Hotels Southeastern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southeastern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southeastern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southeastern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Southeastern Indiana hotel reviews by fellow wanderers

Comfort Inn & Suites Clarksville - Louisville North

Comfort Inn & Suites Clarksville - Louisville North

4 out of 5
Posted 10 hours ago
Travelocity Verified Review
"The AC worked but had a very irritating sound associated with it running. We stayed there for 3 days and I notified staff and nothing was done. Other than that…very nice and clean for the price."
A verified traveler stayed at Comfort Inn & Suites Clarksville - Louisville North
Comfort Inn & Suites Clarksville - Louisville North

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