Explore top 2026 4 Star Hotels in Southeastern Indiana

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Top Southeastern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $175 total per night from Feb 3 to Feb 4
$175 total
Feb 3 - Feb 4
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.8/10 Excellent! (4,009 reviews)
Great

Reviewed on Jan 25, 2026

Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $244 total per night from Feb 8 to Feb 9
$244 total
Feb 8 - Feb 9
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (1,764 reviews)
Amazing stay!

Reviewed on Jan 27, 2026

Opens in a new windowOmni Louisville Hotel
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $144 total per night from Feb 15 to Feb 16
$144 total
Feb 15 - Feb 16
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
8.8/10 Excellent! (1,153 reviews)
We were treated by a kind and professional young woman at the front desk. We added two to our party and she was incredibly helpful in changing our suite and giving us suggestions for dinner. Our suite was very clean and comfortable. We had a wonderful time. I can’t say enough great things about the ...

Reviewed on Jan 28, 2026

Opens in a new windowEmbassy Suites Louisville Downtown
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $198 total per night from Jan 31 to Feb 1
$198 total
Jan 31 - Feb 1
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.2/10 Wonderful! (1,181 reviews)
Beautiful hotel and friendly staff! Room was large & comfortable.

Reviewed on Jan 28, 2026

Opens in a new windowThe Brown Hotel
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

4 out of 5
730 E Market St Louisville KY
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $147 total per night from Feb 1 to Feb 2
$147 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features 2 restaurants and 3 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.
9.2/10 Wonderful! (1,034 reviews)
We loved our stay for a quick getaway. We arrived on a Sunday. Our only wish was that the market and coffee shop were open for a snack before dinner. Other than that it was wonderful!

Reviewed on Jan 20, 2026

Opens in a new windowHotel Genevieve part of JdV by Hyatt
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $180 total per night from Jan 31 to Feb 1
$180 total
Jan 31 - Feb 1
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,003 reviews)
Great location for Whiskey Row in Downtown Louisville. Hotel was clean, artsy and has a great restaurant on site.

Reviewed on Jan 25, 2026

Opens in a new window21c Museum Hotel Louisville
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $184 total per night from Feb 15 to Feb 16
$184 total
Feb 15 - Feb 16
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.6/10 Excellent! (1,004 reviews)
Excellent

Reviewed on Jan 21, 2026

Opens in a new windowHyatt Regency Louisville
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $179 total per night from Feb 1 to Feb 2
$179 total
Feb 1 - Feb 2
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
9.4/10 Exceptional! (1,005 reviews)
The Grady was wonderful. Staff was friendly, the hotel was clean and charming. We will definitely be returning to the Grady in the future.

Reviewed on Jan 20, 2026

Opens in a new windowThe Grady
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$204 nightly
The price is $240 total per night from Feb 7 to Feb 8
$240 total
Feb 7 - Feb 8
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,000 reviews)
Room was spotless. Staff was top notch. Amenities as expected but I did expect a microwave in the room. There wasn't one. 9/10 experience. Will definitely book again!

Reviewed on Jan 16, 2026

Opens in a new windowLouisville Marriott Downtown
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4 out of 5
101 West Main Street Louisville KY
$193 nightly
The price is $227 total per night from Feb 15 to Feb 16
$227 total
Feb 15 - Feb 16
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (441 reviews)
Beautiful room! Clean and the service at the front desk was great! So kind!

Reviewed on Jan 28, 2026

Opens in a new windowHotel Distil, Autograph Collection
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4 Star Hotels Southeastern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southeastern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southeastern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southeastern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Southeastern Indiana hotel reviews by fellow wanderers

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