Explore top 2026 4 Star Hotels in Southeastern Indiana

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Top Southeastern Indiana 4 Star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $175 total per night from Mar 30 to Mar 31
$175 total
Mar 30 - Mar 31
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9/10 Wonderful! (4,071 reviews)
Very clean and spacious room. Our stay was lovely

Reviewed on Mar 18, 2026

Opens in a new windowGalt House Hotel Trademark Collection by Wyndham
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $134 total per night from Apr 5 to Apr 6
$134 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. ...
9/10 Wonderful! (1,174 reviews)
Great experience

Reviewed on Mar 18, 2026

Opens in a new windowEmbassy Suites Louisville Downtown
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $210 total per night from Apr 2 to Apr 3
$210 total
Apr 2 - Apr 3
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
9.4/10 Exceptional! (1,186 reviews)
This hotel is easily worth the money, and everyone must try the Hot Brown. I visited with my elderly mother, with the idea that local relatives would visit us there. They did. The lobby is excellent for this, and the room offered a sumptuous sofa, which also fit the bill. The Cafe has a limited menu, ...

Reviewed on Mar 17, 2026

Opens in a new windowThe Brown Hotel
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

4 out of 5
730 E Market St Louisville KY
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $158 total per night from Mar 22 to Mar 23
$158 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and a snack bar/deli are also offered.
9.2/10 Wonderful! (1,057 reviews)
Charming hotel with great amenities. Located in the perfect location in NuLu. Staff was extremely accommodating. Staying here again the next time we visit.

Reviewed on Mar 17, 2026

Opens in a new windowHotel Genevieve part of JdV by Hyatt
Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
280 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $197 total per night from Apr 5 to Apr 6
$197 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,000 reviews)
Great!

Reviewed on Mar 15, 2026

Opens in a new windowLouisville Marriott Downtown
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$183 nightly
The price is $216 total per night from Mar 30 to Mar 31
$216 total
Mar 30 - Mar 31
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.4/10 Exceptional! (1,000 reviews)
Prices are exceptionally high (probably the same as everywhere) for what you get in the restaurants.

Reviewed on Mar 17, 2026

Opens in a new window21c Museum Hotel Louisville
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $158 total per night from Apr 4 to Apr 5
$158 total
Apr 4 - Apr 5
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.8/10 Excellent! (1,000 reviews)
The hotel overall was a disappointment this time around. Room was not cleaned all the way through small papers on the floor and other small objects on the couch. Woke up early to loud music at 6am and construction/remodeling banging shortly followed.

Reviewed on Mar 10, 2026

Opens in a new windowHyatt Regency Louisville
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4 out of 5
101 West Main Street Louisville KY
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $206 total per night from Apr 5 to Apr 6
$206 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.6/10 Exceptional! (456 reviews)
Great location

Reviewed on Mar 8, 2026

Opens in a new windowHotel Distil, Autograph Collection
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $200 total per night from Apr 1 to Apr 2
$200 total
Apr 1 - Apr 2
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
9.4/10 Exceptional! (1,002 reviews)
The hotel is beautiful and really conveniently located to bourbon stops, bars and restaurants. We didn't eat at the bar/restaurant but did have cocktails and Travis was amazing. Our room was perfect and we'd definitely stay here again. My only very small piece of feedback was related to the valet. ...

Reviewed on Mar 18, 2026

Opens in a new windowThe Grady
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

4 out of 5
143 West Market St Louisville KY
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $169 total per night from Apr 3 to Apr 4
$169 total
Apr 3 - Apr 4
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 3 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (83 reviews)
Very friendly and helpful staff. Hotel is clean and wonderful.

Reviewed on Mar 16, 2026

Opens in a new windowHotel Bourré Bonne Louisville, Curio Collection by Hilton
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4 Star Hotels Southeastern Indiana

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Southeastern Indiana 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Southeastern Indiana will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Southeastern Indiana, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Southeastern Indiana hotel reviews by fellow wanderers

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