
$210 Cheap American Airlines flights from Houston to Knoxville (HOU to TYS)
Find The Best Day To Fly from Houston to Knoxville
Amazing American Airlines HOU to TYS Flight Deals
The cheapest flights to McGhee Tyson found within the past 7 days were $229 round trip and $210 one way. Prices and availability subject to change. Additional terms may apply.
TYS From HOU Economy Coach Packages on Similar Airlines



Discover our best American Airlines flight from Houston HOU to Knoxville TYS
To find the best deals on flights to Houston from Knoxville with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from Houston HOU to Knoxville TYS with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $229 to $249, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from Houston HOU to Knoxville TYS
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Houston to Knoxville costs from $210. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Knoxville TYS from Houston HOU with American Airlines
To find a cheap American Airlines flight from Houston HOU to Knoxville TYS, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from Houston HOU to Knoxville TYS
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as September, or if you book a flight with a stopover.
Find nonstop flights from Houston HOU to Knoxville TYS with American Airlines
If you’re keen to be on Knoxville soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from Houston HOU to Knoxville TYS
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Knoxville TYS from Houston HOU with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
Airport code | Country | Airport name | Number of flights |
---|---|---|---|
DFW | USA | Dallas-Fort Worth Intl. | 599 |
CLT | USA | Charlotte-Douglas Intl. | 536 |
ORD | USA | O'Hare Intl. | 317 |
PHL | USA | Philadelphia Intl. | 247 |
MIA | USA | Miami Intl. | 193 |
DCA | USA | Ronald Reagan Washington National | 152 |
PHX | USA | Sky Harbor Intl. | 141 |
LAX | USA | Los Angeles Intl. | 81 |
LGA | USA | LaGuardia | 72 |
BOS | USA | Logan Intl. | 57 |
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Popular American Airlines Flight Routes from HOU
Top American Airlines Flight Routes from TYS
- American Airlines TYS to HNL
- American Airlines TYS to DEN
- American Airlines TYS to JFK
- American Airlines TYS to MCO
- American Airlines TYS to ORD
- American Airlines TYS to SNA
- American Airlines TYS to PIT
- American Airlines TYS to DCA
- American Airlines TYS to LGA
- American Airlines TYS to IAH
- American Airlines TYS to DFW
Top Flights for American Airlines originating from HOU
Domestic
- Dallas to Las Vegas (DFW - LAS)
- Ontario to San Salvador (ONT - SAL)
- Dallas to Las Vegas (DFW - LAS)
- Philadelphia to San Juan (PHL - SJU)
- Newark Liberty Intl. Airport to Santo Domingo (EWR - SDQ)
- Philadelphia to Orlando (PHL - MCO)
- New York to Montego Bay (JFK - MBJ)
- Chicago to Las Vegas (ORD - LAS)
- New York to Orlando (JFK - MCO)
- Orlando to San Juan (MCO - SJU)
International
- Newark Liberty Intl. Airport to Orlando (EWR - MCO)
- Los Angeles to Honolulu (LAX - HNL)
- Ontario to San Salvador (ONT - SAL)
- Newark Liberty Intl. Airport to Santiago (EWR - STI)
- Newark Liberty Intl. Airport to San Juan (EWR - SJU)
- New York to Santiago (JFK - STI)
- Ontario to San Salvador (ONT - SAL)
- Newark Liberty Intl. Airport to San Juan (EWR - SJU)
- New York to San Juan (LGA - SJU)
- Philadelphia to Orlando (PHL - MCO)