$213 Cheap American Airlines flights from Charlotte to Knoxville (CLT to TYS)

Find The Best Day To Fly from Charlotte to Knoxville

Amazing American Airlines CLT to TYS Flight Deals

The cheapest flights to McGhee Tyson found within the past 7 days were $367 round trip and $213 one way. Prices and availability subject to change. Additional terms may apply.

Sat, Oct 4 - Wed, Oct 8
CLT
Charlotte
TYS
Knoxville
$367 Roundtrip, found 2 days ago
$367
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Oct 4 from Charlotte to Knoxville, returning Wed, Oct 8, priced at $367 found 2 days ago
Sat, Oct 4 - Wed, Oct 8
CLT
Charlotte
TYS
Knoxville
$388 Roundtrip, found 2 days ago
$388
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Oct 4 from Charlotte to Knoxville, returning Wed, Oct 8, priced at $388 found 2 days ago
Tue, Sep 30 - Tue, Oct 7
CLT
Charlotte
TYS
Knoxville
$407 Roundtrip, found 4 days ago
$407
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Sep 30 from Charlotte to Knoxville, returning Tue, Oct 7, priced at $407 found 4 days ago
Fri, Oct 31 - Tue, Nov 4
CLT
Charlotte
TYS
Knoxville
$444 Roundtrip, found 5 days ago
$444
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Oct 31 from Charlotte to Knoxville, returning Tue, Nov 4, priced at $444 found 5 days ago
Sat, Oct 4 - Wed, Oct 8
CLT
Charlotte
TYS
Knoxville
$447 Roundtrip, found 2 days ago
$447
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Oct 4 from Charlotte to Knoxville, returning Wed, Oct 8, priced at $447 found 2 days ago
Mon, Oct 6 - Sat, Oct 11
CLT
Charlotte
TYS
Knoxville
$449 Roundtrip, found 3 days ago
$449
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Oct 6 from Charlotte to Knoxville, returning Sat, Oct 11, priced at $449 found 3 days ago

Frequently asked questions

Can I catch a flight from Charlotte Airport to TYS right now?
It's always wise to find out about any quarantine requirements and travel advice reports in effect in your destination. Ensure you check out our Covid-19 Travel Advisor for up-to-date info on catching a flight to McGhee Tyson Airport (TYS) from Charlotte Airport.
What terminal is American Airlines at Charlotte Airport?
If you're flying with American Airlines from Charlotte Airport, you'll generally be boarding from the main terminal. If you're jetting to TYS from here, you're likely to be arriving at the main terminal.
Are there American Airlines non-stop flights from CLT to TYS?
If you're going from CLT to TYS and prefer to fly direct, American Airlines will sort you out. Choose your favorite seat now and you'll be vacationing at your destination before long.
How long is an American Airlines flight from CLT to TYS?
If conditions are good and there are no air traffic delays, your American Airlines flight from CLT to TYS should take roughly 2 hours and 15 minutes. Make use of that short journey to fine tune your travel itinerary before you disembark.
What type of aircraft does American Airlines fly from CLT to TYS?
Looking for a flight between Charlotte-Douglas Intl. Airport (CLT) and McGhee Tyson Airport (TYS) with American Airlines? On this route, you'll probably be climbing aboard the Bombardier CRJ900 or the Airbus A319 type aircraft.
How many direct and indirect flights does American Airlines fly from CLT to TYS?
You'll find there are about 4 American Airlines flights every day from CLT to TYS.
If I am not able to travel due to COVID-19, can I change my booking to a later date?
For more info about changing your flight to McGhee Tyson Airport (TYS), please visit our Customer Service Portal.
What is the best day to buy a plane ticket?
This just in! Airfares offered on Thursdays tend to be the cheapest, according to flight demand on Travelocity in 2021. Tuesday and Wednesday prices are also good, but you may want to prepare your budget if booking during the weekend, as data shows that is when prices are generally at their highest.
What are the cheapest days to fly?
Frequent travelers may already know this, but earlier in the week can be the cheapest time to fly. In 2021, flights departing on a Monday were generally the cheapest of the week, whereas you may pay a premium for weekend flights when demand is usually high. On average, tickets were most expensive for Saturday departures, so if you need to fly out on a weekend, you might look for deals ahead of time.
How far in advance can you book a flight?
Trying to figure out how early you should book your flight? It's possible to start comparing international airfares on Travelocity up to 12 months in advance. However, it does depend on the carrier as not all airlines release their prices that far out. According to our 2021 flight demand trends, last minute planners can still bag a bargain with some of the cheapest fares appearing 0-2 weeks prior to their travel dates.*According to flight demand on Travelocity.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Discover our best American Airlines flight from Charlotte CLT to Knoxville TYS 

To find the best deals on flights to Charlotte from Knoxville with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find 7 flights to choose from and can sort by price, flight duration, and arrival or departure time.  

 

Return flights from Charlotte CLT to Knoxville TYS with American Airlines 

If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $367 to $449, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply. 

 

Book one-way American Airlines flights from Charlotte CLT to Knoxville TYS 

A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Charlotte to Knoxville costs from $213. Prices and availability subject to change. Additional terms may apply. 

 

The easy way to find cheap flights to Knoxville TYS from  Charlotte CLT with American Airlines 

To find a cheap American Airlines flight from Charlotte CLT to Knoxville TYS, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference. 

 

How to find our best airfare deals on American Airlines flights from Charlotte CLT to Knoxville TYS 

If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as October, or if you book a flight with a stopover. 

 

Find nonstop flights from Charlotte CLT to Knoxville TYS with American Airlines 

If you’re keen to be on Knoxville soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around 1 hour(s) 0 min(s) – so you’ll be there before you know it. 

 

Flexible airline tickets for American Airlines flights from Charlotte CLT to Knoxville TYS 

Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.  

 

There are a lot of reasons to book your flights to Knoxville TYS from  Charlotte CLT with American Airlines on Travelocity 

At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.

American Airlines Airports
Hop on a(n) American Airlines flight today by flying to many destinations out of these domestic and international airports:
Airport code
Country
Airport name
Number of flights
DFWUSADallas-Fort Worth Intl.599
CLTUSACharlotte-Douglas Intl.536
ORDUSAO'Hare Intl.317
PHLUSAPhiladelphia Intl.247
MIAUSAMiami Intl.193
DCAUSARonald Reagan Washington National152
PHXUSASky Harbor Intl.141
LAXUSALos Angeles Intl.81
LGAUSALaGuardia72
BOSUSALogan Intl.57

Travelers ❤️ these 🏨 after their flight to Knoxville

Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy, Alcoa, TN
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,012 reviews)
Top notch hotel
"This was a great way to end my vacation, since my flight arrived at a late hour into TYS. It is an easy and straight walk from baggage claim to the Hilton,or they will come get you in their shuttle. The hotel is great. Pool is fun, too, Restaurant and bar on site."

Reviewed on Jul 26, 2025

Hilton Knoxville Airport
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road, Alcoa, TN
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free ...
8.6/10 Excellent! (1,505 reviews)
"Very friendly staff, quite nice place to stay"

Reviewed on Jul 27, 2025

La Quinta Inn & Suites by Wyndham Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd, Alcoa, TN
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport ...
8.4/10 Very Good! (1,009 reviews)
"The room was nice and clean, and the beds were very comfortable!"

Reviewed on Jul 26, 2025

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.