
$169 Cheap American Airlines flights from Chicago to Knoxville (ORD to TYS)
Find The Best Day To Fly from Chicago to Knoxville
Amazing American Airlines ORD to TYS Flight Deals
The cheapest flights to McGhee Tyson found within the past 7 days were $189 round trip and $169 one way. Prices and availability subject to change. Additional terms may apply.
TYS From ORD Economy Coach Packages on Similar Airlines



Frequently asked questions
Discover our best American Airlines flight from Chicago ORD to Knoxville TYS
To find the best deals on flights to Chicago from Knoxville with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from Chicago ORD to Knoxville TYS with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $189 to $219, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from Chicago ORD to Knoxville TYS
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Chicago to Knoxville costs from $169. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Knoxville TYS from Chicago ORD with American Airlines
To find a cheap American Airlines flight from Chicago ORD to Knoxville TYS, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from Chicago ORD to Knoxville TYS
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as October, or if you book a flight with a stopover.
Find nonstop flights from Chicago ORD to Knoxville TYS with American Airlines
If you’re keen to be on Knoxville soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from Chicago ORD to Knoxville TYS
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Knoxville TYS from Chicago ORD with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
Airport code | Country | Airport name | Number of flights |
---|---|---|---|
DFW | USA | Dallas-Fort Worth Intl. | 599 |
CLT | USA | Charlotte-Douglas Intl. | 536 |
ORD | USA | O'Hare Intl. | 317 |
PHL | USA | Philadelphia Intl. | 247 |
MIA | USA | Miami Intl. | 193 |
DCA | USA | Ronald Reagan Washington National | 152 |
PHX | USA | Sky Harbor Intl. | 141 |
LAX | USA | Los Angeles Intl. | 81 |
LGA | USA | LaGuardia | 72 |
BOS | USA | Logan Intl. | 57 |
Travelers ❤️ these 🏨 after their flight to Knoxville

Hilton Knoxville Airport
Reviewed on Jul 26, 2025

La Quinta Inn & Suites by Wyndham Knoxville Airport
Reviewed on Jul 27, 2025

Best Western Knoxville Airport/Alcoa
Reviewed on Jul 26, 2025
Popular American Airlines Flight Routes from ORD
- American Airlines ORD to ATH
- American Airlines ORD to TPA
- American Airlines ORD to MIA
- American Airlines ORD to RSW
- American Airlines ORD to JFK
- American Airlines ORD to BOS
- American Airlines ORD to PHX
- American Airlines ORD to LAX
- American Airlines ORD to CUN
- American Airlines ORD to FCO
- American Airlines ORD to SAN
Top American Airlines Flight Routes from TYS
Top Flights for American Airlines originating from ORD
Domestic
- New York to Orlando (JFK - MCO)
- New York to Santiago (JFK - STI)
- Orlando to San Juan (MCO - SJU)
- Philadelphia to Orlando (PHL - MCO)
- Newark Liberty Intl. Airport to Las Vegas (EWR - LAS)
- Boston to Orlando (BOS - MCO)
- Boston to Orlando (BOS - MCO)
- Chicago to Las Vegas (ORD - LAS)
- Chicago to Las Vegas (ORD - LAS)
- Newark Liberty Intl. Airport to San Juan (EWR - SJU)
International
- New York to Santiago (JFK - STI)
- New York to San Juan (JFK - SJU)
- Newark Liberty Intl. Airport to San Juan (EWR - SJU)
- Chicago to Mexico City (ORD - MEX)
- Newark Liberty Intl. Airport to Miami (EWR - MIA)
- Orlando to San Juan (MCO - SJU)
- San Juan to Orlando (SJU - MCO)
- Orlando to San Juan (MCO - SJU)
- Philadelphia to San Juan (PHL - SJU)
- Philadelphia to Orlando (PHL - MCO)
Most Popular
- PHX to ORD Flights
- LAX to ORD Flights
- DFW to BNA Flights
- PHL to ORD Flights
- LAX to BNA Flights
- BNA to JFK Flights
- JetBlue Airways Boston (BOS) to Nashville (BNA) flights
- ORD to MIA Flights
- PHL to BNA Flights
- ORD to DCA Flights
- ORD to MCO Flights
- ORD to TPA Flights
- BNA to LAX Flights
- ORD to MEX Flights
- JetBlue Airways New York (JFK) to Nashville (BNA) flights
- ORD to PHX Flights
- ORD to DFW Flights
- BNA to MCO Flights
- ORD to ATL Flights
- ORD to BNA Flights
- ORD to PHL Flights
- ORD to SFO Flights
- TPA to ORD Flights
- DFW to ORD Flights
- ORD to BOS Flights
- MCO to ORD Flights
- SFO to ORD Flights
- DEN to ORD Flights
- ORD to LAX Flights
- ORD to CUN Flights