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Top hotels in Medical Center District
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $151 total per night from Jul 6 to Jul 7
$151 total
Jul 6 - Jul 7
Total with taxes and fees
2 hot tubs, an outdoor pool, and an indoor pool are all featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public ...
"Just overall Awesome!!"
Reviewed on Jun 30, 2026
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
$158 nightly
The price is $185 total per night from Jul 10 to Jul 11
$185 total
Jul 10 - Jul 11
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
"The hotel has valet parking for $67 a night. We decided to park around the corner for $15 a night. At a garage parking lot. And just like every other hotel, just expect more charges on your way out we stayed there three nights and got charged an additional $150 for taxes for destination charges, ..."
Reviewed on Jun 30, 2026
Drury Inn & Suites San Antonio Northwest Medical Center
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $106 total per night from Jul 5 to Jul 6
$106 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Some paint and cracks in bathroom and room need attention but small details."
Reviewed on Jun 29, 2026
JW Marriott San Antonio Hill Country Resort & Spa
23808 Resort Pkwy San Antonio TX
$443 nightly
The price is $517 total per night from Jul 1 to Jul 2
$517 total
Jul 1 - Jul 2
Total with taxes and fees
This luxury hotel features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, and ...
"Clean rooms, excellent courteous staff, great water rides and awesome Lazy River."
Reviewed on Jun 30, 2026
Courtyard by Marriott Medical Center San Antonio
8585 Marriott Dr San Antonio TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Jul 10 to Jul 11
$105 total
Jul 10 - Jul 11
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Staff was very nice"
Reviewed on Jun 30, 2026
Menger Hotel
204 Alamo Plaza San Antonio TX
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $113 total per night from Jul 7 to Jul 8
$113 total
Jul 7 - Jul 8
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet ...
"It felt like stepping back in time. The antique decor and rooms were so elegant. The courtyard was beautiful and it was just steps away from the Alamo abs river center mall"
Reviewed on Jun 30, 2026
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $130 total per night from Jul 31 to Aug 1
$130 total
Jul 31 - Aug 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the laundry service and WiFi in public areas. There's ...
"Room was nice and service was good. Our stay was interrupted by a power outage in the whole hotel and after the outage our air conditioner wouldn't blow cool air. I did address it to the staff and it was going to be relayed to maintenance but the hot air made it uncomfortable to sleep."
Reviewed on Jun 29, 2026
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Jul 5 to Jul 6
$105 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling for business? Take advantage of the free WiFi in public areas, express check-out, and conference center. ...
"Because breakfast hours were an hour later due to a holiday and I had an early appointment, I was not able to eat breakfast. It was Juneteenth"
Reviewed on Jun 30, 2026
Riverwalk Plaza
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $117 total per night from Jul 5 to Jul 6
$117 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. Valet parking, a 24-hour business center, ...
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Medical Center District Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Medical Center District hotel reviews by fellow wanderers
Drury Plaza Hotel San Antonio Riverwalk
5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Just overall Awesome!!"
A verified traveler stayed at Drury Plaza Hotel San Antonio Riverwalk
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