Book Hotels in Upstate South Carolina, SC

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Top Upstate South Carolina hotels

Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
Free WiFi in public areas is available at this cottage.
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Opens in a new windowWooded Cottage - 3 Mi to Clemson University
Homewood Suites by Hilton Greenville Downtown

Homewood Suites by Hilton Greenville Downtown

3 out of 5
950 South Main Street Greenville SC
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $147 total per night from Jan 11 to Jan 12
$147 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
We enjoyed our stay very much. The front desk staff was welcoming and accommodating to our special requests. Our room was spacious, clean and quiet and the beds were comfortable. We also enjoyed seeing the sunset over the mountains out of our bedroom window. Will definitely recommend and keep in ...

Reviewed on Jan 5, 2026

Opens in a new windowHomewood Suites by Hilton Greenville Downtown
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$235 nightly
The price is $259 total per night from Jan 28 to Jan 29
$259 total
Jan 28 - Jan 29
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
Lovely property in the heart of downtown Greenville. Rooms are spacious and well appointed, we found beds to be rather soft and not very supportive. We had a partial view of the river and Falls Park. The hotel has several solaces dedicated to artwork, a restaurant and bar. Good was fine. We were ...

Reviewed on Jan 7, 2026

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
The Westin Poinsett Greenville

The Westin Poinsett Greenville

4 out of 5
120 South Main St Greenville SC
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $197 total per night from Jan 25 to Jan 26
$197 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...
Yes the bar & the staff that worked at mid shift were excellent. The breakfast & presentation with the staff coordination exceeded my expectations...

Reviewed on Jan 2, 2026

Opens in a new windowThe Westin Poinsett Greenville
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $104 total per night from Jan 25 to Jan 26
$104 total
Jan 25 - Jan 26
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
It was wonderful, staff was very nice

Reviewed on Jan 5, 2026

Opens in a new windowEmbassy Suites Greenville Golf Resort & Conference Center
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

3 out of 5
11 Ketron Court Greenville SC
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $94 total per night from Jan 11 to Jan 12
$94 total
Jan 11 - Jan 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast and free WiFi. Traveling on business? Take advantage of the 24-hour business center and ...
Staff was very nice. Perfect location. Breakfast was good. Room was clean, no carpet, and didn’t smell like mold.

Reviewed on Jan 4, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $163 total per night from Jan 18 to Jan 19
$163 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Great

Reviewed on Jan 7, 2026

Opens in a new windowHyatt Regency Greenville
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $110 total per night from Jan 25 to Jan 26
$110 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Breakfast is extra

Reviewed on Jan 2, 2026

Opens in a new windowHilton Greenville
Best Western Greenville Airport Inn

Best Western Greenville Airport Inn

2.5 out of 5
5009 Pelham Road Greenville SC
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $79 total per night from Jan 9 to Jan 10
$79 total
Jan 9 - Jan 10
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Free perks include full breakfast, free self parking, and a roundtrip airport shuttle. A 24-hour business ...
It was clean nice peaceful and quiet no disturbance rest well great

Reviewed on Dec 24, 2025

Opens in a new windowBest Western Greenville Airport Inn
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Upstate South Carolina hotels

Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson

128 Interstate Blvd Anderson SC
$60 nightly
The price is $66 total per night from Jan 18 to Jan 19
$66 total
Jan 18 - Jan 19
Total with taxes and fees
7/10 Good! (847 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Hyatt Regency Greenville

Hyatt Regency Greenville

5 out of 5
Posted 13 hours ago
Travelocity Verified Review
"Great"
A verified traveler stayed at Hyatt Regency Greenville
Hyatt Regency Greenville

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