Book Hotels in Upstate South Carolina, SC

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Top Upstate South Carolina hotels

Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson
Free WiFi in public areas is available at this cottage. Take advantage of the free self parking.
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Wooded Cottage - 3 Mi to Clemson University
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY, Greenville, SC
$242 nightly
The price is $266 total per night from Sep 14 to Sep 15
$266 total
Sep 14 - Sep 15
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
Beautiful hotel. Housekeeping could use some help.
"The 2 ladies at check in were beyond amazing The room was clean and nice. Everything was up to standards besides housekeeping. We left the room before 11 and came back after three and the room was not made up. We saw the housekeeper and she said that we could wait downstairs and she would do the ..."

Reviewed on Aug 21, 2025

Grand Bohemian Lodge Greenville, Autograph Collection
Courtyard by Marriott Greenville Haywood Mall

Courtyard by Marriott Greenville Haywood Mall

3 out of 5
70 Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $121 total per night from Aug 25 to Aug 26
$121 total
Aug 25 - Aug 26
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
"Bed was super comfortable! Beautiful bathroom."

Reviewed on Aug 14, 2025

Courtyard by Marriott Greenville Haywood Mall
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Aug 24 to Aug 25
$153 total
Aug 24 - Aug 25
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Staff was fantastic, room was clean & perfect for a getaway!"

Reviewed on Aug 18, 2025

Hyatt Regency Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd, Greenville, SC
Fully refundable
$95 nightly
The price is $105 total per night from Aug 24 to Aug 25
$105 total
Aug 24 - Aug 25
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Great hotel , would stay again ."

Reviewed on Aug 16, 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Woodspring Suites Greenville Airport

Woodspring Suites Greenville Airport

2.5 out of 5
205 Entertainment Blvd, Greenville, SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $92 total per night from Aug 24 to Aug 25
$92 total
Aug 24 - Aug 25
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage and laundry facilities are also provided.
"Convenient location within walking distance to a fun plex with bowling arcade billiards & dining. Right next to Top Golf too. The room was promoted as an efficiency with full kitchen. While there was indeed a full kitchen it was not stocked with anything we would expect to find. There were no dishes ..."

Reviewed on Aug 16, 2025

Woodspring Suites Greenville Airport
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $117 total per night from Sep 3 to Sep 4
$117 total
Sep 3 - Sep 4
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Great place to stay for me while working at the University. Quiet, great staff, clean and a great breakfast selection. As well as a restaurant on site. Made it easy. Also a par 30 golf course only 10 minutes away. And a gas station/ convenience store essentially in the parking lot."

Reviewed on Aug 19, 2025

Best Western Plus Clemson Hotel & Conference Center
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from Sep 4 to Sep 5
$99 total
Sep 4 - Sep 5
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
"Todo perfecto"

Reviewed on Aug 19, 2025

Hilton Greenville
La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

3 out of 5
65 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $80 total per night from Aug 24 to Aug 25
$80 total
Aug 24 - Aug 25
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. ...
"The room was spacious and the bed was comfortable. I was disappointed that the room didn't have a microwave in it. The front elevator being repaired was inconvenient, but I don't expect that to be an ongoing problem. The breakfast was limited in choices and not at the same standard of similar properties ..."

Reviewed on Aug 18, 2025

La Quinta Inn & Suites by Wyndham Greenville Haywood
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Upstate South Carolina hotels

Baymont by Wyndham Anderson Clemson

Baymont by Wyndham Anderson Clemson

128 Interstate Blvd, Anderson, SC
$68 nightly
The price is $75 total per night from Sep 12 to Sep 13
$75 total
Sep 12 - Sep 13
Total with taxes and fees
6.8/10 (812 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Great place to stay for me while working at the University. Quiet, great staff, clean and a great breakfast selection. As well as a restaurant on site. Made it easy. Also a par 30 golf course only 10 minutes away. And a gas station/ convenience store essentially in the parking lot. "
A verified traveler stayed at Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
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