Mississippi County Vacation Packages 2026

Top Mississippi County hotels deals

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

Free Cancellation

Reserve now, pay when you stay

$61 nightly

$68 total

Jun 1 - Jun 2

Total with taxes and fees

This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. There's a computer station and multilingual staff can provide around-the-clock assistance.

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO

Free Cancellation

Reserve now, pay when you stay

$75 nightly

$83 total

May 9 - May 10

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business center and free internet in public areas. A safe deposit box is provided and the front desk is staffed around-the-clock.

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$111 nightly

$128 total

May 12 - May 13

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$102 nightly

$115 total

May 17 - May 18

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. A 24-hour business center, a snack bar/deli, and express check-out are also on offer.

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$81 nightly

$92 total

May 20 - May 21

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour business center, a grocery/convenience store, and express check-out are also on offer.

Peaceful secluded cabin located near Horseshoe Lake

Miller City IL

$189 nightly

$200 total

May 10 - May 11

Total with taxes and fees

This cabin features barbecue grills.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Photos of local treasures

Browse Mississippi County vacation photos for more inspiration

MAY 17 2019, HERMANN MISSOURI USA - The Hermann Bridge was a cantilevered truss bridge over the Missouri River at Hermann, Missouri between Gasconade and Montgomery County

Frequently asked questions

How much are vacation packages to Mississippi County?

With vacation packages on offer for only , it's not necessary to drain your bank balance for your trip to Mississippi County. Travelocity is here to help. Bundle up experiences, hotels and flights into a package and receive some excellent discounts. The more you book, the more you save.

Where can I get the best vacation package deals for Mississippi County?

No matter what you enjoy doing, Travelocity can help you get your hands on the best Mississippi County package deal. The only thing you have to do is select a combination from our 400 airlines and 1,000,000 properties around the world.

Why should I book my Mississippi County vacation bundle with Travelocity?

By booking your hotel, flights, activities and car rental all in one place, you'll save time and money. We have a dedicated team of experts available 24/7, and you'll know that you'll always score the lowest price possible with our Price Match Guarantee. So, what are you waiting for? Book your dream getaway today and get packing!

Can I save money on my Mississippi County car rental if I bundle it with my hotel or flight?

You certainly can with our Mississippi County vacation packages. With one of these, there are plenty of ways to stretch your travel budget further. Bundle any two or more car, hotel, flight and tour bookings and watch your savings pile up. With your own ride, all the main sights around Mississippi County are within your reach.

Which airport is best for Mississippi County?

If you're going to fly into Mississippi County, it's likely you'll be touching down at Cape Girardeau Municipal Airport (CGI) or Barkley Regional Airport (PAH).