Deals on vacations and trips to Mississippi County

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Mississippi County flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.
University Inn of Carbondale

University Inn of Carbondale

2.5 out of 5
Price was $623, price is now $615 per person
$615
per person
Nov 11 - Nov 14
found 1 day ago
Roundtrip non-stop flight included
Syracuse (SYR) to Cape Girardeau (CGI)
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide around-the-clock assistance.
Makanda Inn

Makanda Inn

3.5 out of 5
Price was $860, price is now $822 per person
$822
per person
Nov 11 - Nov 14
found 1 day ago
Roundtrip non-stop flight included
Syracuse (SYR) to Cape Girardeau (CGI)
A restaurant and a bar/lounge are featured at this bed & breakfast. Guests will appreciate free perks like free self parking and WiFi in public areas. A coffee shop, a terrace, and a lobby fireplace are also on offer.
Super 8 by Wyndham Carbondale

Super 8 by Wyndham Carbondale

2 out of 5
Price was $626, price is now $617 per person
$617
per person
Nov 11 - Nov 14
found 1 day ago
Roundtrip non-stop flight included
Syracuse (SYR) to Cape Girardeau (CGI)
This motel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Multilingual staff at the 24-hour front desk can provide around-the-clock assistance.
Comfort Inn & Suites Carbondale University Area

Comfort Inn & Suites Carbondale University Area

2.5 out of 5
Price was $672, price is now $663 per person
$663
per person
Nov 11 - Nov 14
found 1 day ago
Roundtrip non-stop flight included
Syracuse (SYR) to Cape Girardeau (CGI)
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Hampton Inn Carbondale

Hampton Inn Carbondale

2.5 out of 5
Price was $740, price is now $731 per person
$731
per person
Nov 11 - Nov 14
found 1 day ago
Roundtrip non-stop flight included
Syracuse (SYR) to Cape Girardeau (CGI)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like buffet breakfast and free self parking.

Top Mississippi County hotels deals

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
Free Cancellation
$66 nightly
The price is $74 total per night
$74 total
Oct 15 - Oct 16
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 24-hour business center and free internet in public areas. Enjoy the seasonal outdoor pool and conveniences like a 24-hour front desk and laundry facilities.
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Free Cancellation
Reserve now, pay when you stay
$60 nightly
The price is $67 total per night
$67 total
Oct 13 - Oct 14
Total with taxes and fees
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. There's a computer station and multilingual staff can provide around-the-clock assistance.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$94 nightly
The price is $108 total per night
$108 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$66 nightly
The price is $76 total per night
$76 total
Nov 1 - Nov 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$105 nightly
The price is $120 total per night
$120 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. A 24-hour business center, a snack bar/deli, and express check-out are also on offer.
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$85 nightly
The price is $97 total per night
$97 total
Nov 1 - Nov 2
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour business center, a grocery/convenience store, and express check-out are also on offer.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Mississippi County attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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Photos of local treasures

Browse Mississippi County vacation photos for more inspiration

A bridge over a muddy river with green trees and hills in the background.

Frequently asked questions

How much are vacation packages to Mississippi County?
With vacation packages on offer for only $615, it's not necessary to drain your bank balance for your trip to Mississippi County. Travelocity is here to help. Bundle up experiences, hotels and flights into a package and receive some excellent discounts. The more you book, the more you save.
Where can I get the best vacation package deals for Mississippi County?
No matter what you enjoy doing, Travelocity can help you get your hands on the best Mississippi County package deal. The only thing you have to do is select a combination from our 400 airlines and 1,000,000 properties around the world.
Why should I book my Mississippi County vacation bundle with Travelocity?
By booking your hotel, flights, activities and car rental all in one place, you'll save time and money. We have a dedicated team of experts available 24/7, and you'll know that you'll always score the lowest price possible with our Price Match Guarantee. So, what are you waiting for? Book your dream getaway today and get packing!
Can I save money on my Mississippi County car rental if I bundle it with my hotel or flight?
You certainly can with our Mississippi County vacation packages. With one of these, there are plenty of ways to stretch your travel budget further. Bundle any two or more car, hotel, flight and tour bookings and watch your savings pile up. With your own ride, all the main sights around Mississippi County are within your reach.
Which airport is best for Mississippi County?
If you're going to fly into Mississippi County, it's likely you'll be touching down at Cape Girardeau Municipal Airport (CGI) or Barkley Regional Airport (PAH).

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