Find a Hotel in Matlacha Isles

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top hotels in Matlacha Isles

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina

4 out of 5
275 Estero Blvd Fort Myers Beach FL
$298 nightly
The price is $332 total per night from Nov 15 to Nov 16
$332 total
Nov 15 - Nov 16
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Enjoy the 3 outdoor pools and free buffet breakfast each morning. Enjoy the ...
"The Pink Shell has a great location and is fantastic for families. It has great food and the staff are generally happy to help. But if you're looking for a relaxing, quiet stay then I would recommend elsewhere as the pool music was incredibly loud and if you stay on the 9th floor of the main building ..."

Reviewed on Nov 9, 2026

Opens in a new windowPink Shell Beach Resort and Marina
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
$224 nightly
The price is $250 total per night from Nov 11 to Nov 12
$250 total
Nov 11 - Nov 12
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink ...
"Lovely stay. Great staff and relaxing environment."

Reviewed on Nov 9, 2026

Opens in a new windowSanibel Island Beach Resort
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3 out of 5
12600 University Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $113 total per night from Nov 16 to Nov 17
$113 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Excellent location and customer service"

Reviewed on Nov 9, 2026

Opens in a new windowHilton Garden Inn Ft Myers
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $196 total per night from Dec 7 to Dec 8
$196 total
Dec 7 - Dec 8
Total with taxes and fees
This smoke-free hotel features 3 restaurants, 3 beach bars, and 6 bars/lounges. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Enjoy ...
"We enjoyed our stay overall. The positives: great location, wonderful bars and restaurants right on the beach, helpful/friendly staff, and fun and laid back people staying there. Con: they need to invest in new sheets and bedding, art work of some kind in the room, new chairs/pillows/etc in the pool ..."

Reviewed on Nov 9, 2026

Opens in a new windowLani Kai Beachfront Resort
The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites

3 out of 5
1051 5th St Fort Myers Beach FL
$140 nightly
The price is $157 total per night from Nov 16 to Nov 17
$157 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Relax with a drink at the poolside bar and enjoy perks like free self parking and free WiFi. ...
"I knew about the elevators, not news, but we had to go up four flights of stairs and it was a very confusing hotel. We arrived to our room where the TV was not working, which took over an hour to get fixed. we finally made it down to grab lunch, which was very good and Jamie the bartender was very ..."

Reviewed on Nov 9, 2026

Opens in a new windowThe Lighthouse Resort Inn & Suites
Baymont by Wyndham Fort Myers Central

Baymont by Wyndham Fort Myers Central

2.5 out of 5
4850 S Cleveland Ave Fort Myers FL
Fully refundableReserve now, pay when you stay
$53 nightly
The price is $59 total per night from Nov 11 to Nov 12
$59 total
Nov 11 - Nov 12
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
"This is a low-budget hotel and you get what you pay for. The bathroom light was so dim i could barely see the shower. However, when I told the front desk, they repaired it that same day. The repair lasted two days and when I returned, a very nice gentleman was repairing it again. This time without ..."

Reviewed on Nov 8, 2026

Opens in a new windowBaymont by Wyndham Fort Myers Central
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4 out of 5
17260 Harbour Pointe Dr Fort Myers FL
$255 nightly
The price is $284 total per night from Nov 23 to Nov 24
$284 total
Nov 23 - Nov 24
Total with taxes and fees
A full-service spa, 4 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the 5 outdoor tennis courts and indoor pool, and unwind ...
Opens in a new windowMarriott Sanibel Harbour Resort & Spa
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $237 total per night from Nov 29 to Nov 30
$237 total
Nov 29 - Nov 30
Total with taxes and fees
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
Opens in a new windowMargaritaville Beach Resort Fort Myers
Quality Inn Fort Myers Cape Coral

Quality Inn Fort Myers Cape Coral

2 out of 5
4760 S Cleveland Ave Fort Myers FL
Fully refundable
$58 nightly
The price is $64 total per night from Nov 30 to Dec 1
$64 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the laundry service. There's ...
Opens in a new windowQuality Inn Fort Myers Cape Coral
Don't see what you're looking for?
See all available properties in Matlacha Isles
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Matlacha Isles Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Matlacha Isles area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Matlacha Isles to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Matlacha Isles are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Matlacha Isles hotel reviews by fellow wanderers

Sanibel Island Beach Resort

Sanibel Island Beach Resort

5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Lovely stay. Great staff and relaxing environment."
A verified traveler stayed at Sanibel Island Beach Resort
Sanibel Island Beach Resort

Explore More Ways to Travel with Travelocity