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Top hotels in Matlacha Isles

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$210 nightly
The price is $234 total per night from Nov 29 to Nov 30
$234 total
Nov 29 - Nov 30
Total with taxes and fees
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"Super friendly staff. Easy valet and check in. Rooms are amazing. Pools are beautiful. Restaurants are top notch!"

Reviewed on Nov 2, 2026

Opens in a new windowMargaritaville Beach Resort Fort Myers
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3 out of 5
12600 University Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $113 total per night from Nov 9 to Nov 10
$113 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"The breakfast is very expensive for what you get. I’ve had more options at breakfast included hotels. The bed was not comfortable, I realized on my last day there it was a king mattress on top of a queen or double boxspring!"

Reviewed on Nov 2, 2026

Opens in a new windowHilton Garden Inn Ft Myers
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $196 total per night from Dec 3 to Dec 4
$196 total
Dec 3 - Dec 4
Total with taxes and fees
This smoke-free hotel features 3 restaurants, 3 beach bars, and 6 bars/lounges. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Enjoy ...
"Ok"

Reviewed on Nov 3, 2026

Opens in a new windowLani Kai Beachfront Resort
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4 out of 5
17260 Harbour Pointe Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $266 total per night from Nov 17 to Nov 18
$266 total
Nov 17 - Nov 18
Total with taxes and fees
A full-service spa, 4 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the 5 outdoor tennis courts and indoor pool, and unwind ...
"Beautiful resort. The fitness center was well equipped and clean. The pools were wonderful. Dolphins were observed feeding just off the dock. The walking paths are nice. Even off season there were plenty of staff in restaurant and at the pool cafe. Great view off the balcony of our room. Be prepared ..."

Reviewed on Oct 30, 2026

Opens in a new windowMarriott Sanibel Harbour Resort & Spa
Baymont by Wyndham Fort Myers Central

Baymont by Wyndham Fort Myers Central

2.5 out of 5
4850 S Cleveland Ave Fort Myers FL
Fully refundableReserve now, pay when you stay
$53 nightly
The price is $59 total per night from Nov 5 to Nov 6
$59 total
Nov 5 - Nov 6
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
"Stains on sheets and smell right when I walked in the room. With the AC on 62° I was still sweating throughout the night. I would highly not recommend this place. Shady things go on in the parking lot as well."

Reviewed on Nov 1, 2026

Opens in a new windowBaymont by Wyndham Fort Myers Central
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
$224 nightly
The price is $250 total per night from Nov 5 to Nov 6
$250 total
Nov 5 - Nov 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink ...
Opens in a new windowSanibel Island Beach Resort
The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites

3 out of 5
1051 5th St Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $157 total per night from Dec 1 to Dec 2
$157 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Relax with a drink at the poolside bar and enjoy perks like free self parking and free WiFi. ...
Opens in a new windowThe Lighthouse Resort Inn & Suites
Quality Inn Fort Myers Cape Coral

Quality Inn Fort Myers Cape Coral

2 out of 5
4760 S Cleveland Ave Fort Myers FL
Fully refundable
$55 nightly
The price is $60 total per night from Nov 29 to Nov 30
$60 total
Nov 29 - Nov 30
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the laundry service. There's ...
Opens in a new windowQuality Inn Fort Myers Cape Coral
Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina

4 out of 5
275 Estero Blvd Fort Myers Beach FL
$298 nightly
The price is $332 total per night from Nov 15 to Nov 16
$332 total
Nov 15 - Nov 16
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Enjoy the 3 outdoor pools and free buffet breakfast each morning. Enjoy the ...
Opens in a new windowPink Shell Beach Resort and Marina
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Matlacha Isles Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Matlacha Isles area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Matlacha Isles to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Matlacha Isles are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Matlacha Isles hotel reviews by fellow wanderers

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

4 out of 5
Posted 8 hours ago
Travelocity Verified Review
"Ok"
A verified traveler stayed at Lani Kai Beachfront Resort
Lani Kai Beachfront Resort

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