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Top hotels in Matlacha Isles

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

2.5 out of 5
11171 Summerlin Square Drive Fort Myers Beach FL
Fully refundable
$116 nightly
The price is $129 total per night from Apr 9 to Apr 10
$129 total
Apr 9 - Apr 10
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Yes

Reviewed on Mar 25, 2026

Opens in a new windowHoliday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
$306 nightly
The price is $339 total per night from Apr 26 to Apr 27
$339 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink ...
Everything was excellent and access for the activities we were involved in was perfect.

Reviewed on Mar 25, 2026

Opens in a new windowSanibel Island Beach Resort
DiamondHead Beach Resort

DiamondHead Beach Resort

3.5 out of 5
2000 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$370 nightly
The price is $413 total per night from Apr 22 to Apr 23
$413 total
Apr 22 - Apr 23
Total with taxes and fees
This smoke-free resort features 2 hot tubs, an outdoor pool, and a restaurant. Dine at the beachfront restaurant and relax with beach umbrellas. Enjoy the gym ...
Onsite restaurants were really good.

Reviewed on Mar 25, 2026

Opens in a new windowDiamondHead Beach Resort
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
$360 nightly
The price is $402 total per night from Apr 19 to Apr 20
$402 total
Apr 19 - Apr 20
Total with taxes and fees
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Relax with a drink at one of the 4 bars/lounges and get perks ...
Newly constructed, pristine hotel. I was most worried about the valet but it was super easy. Note they do add resort fees and valet fees at check out. I would stay here again! Pool and beach area are great!!

Reviewed on Mar 26, 2026

Opens in a new windowMargaritaville Beach Resort Fort Myers
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$298 nightly
The price is $333 total per night from Apr 22 to Apr 23
$333 total
Apr 22 - Apr 23
Total with taxes and fees
This smoke-free hotel features 3 restaurants, 3 beach bars, and 6 bars/lounges. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Enjoy ...
Nice resort with everything you need on site. Staff was very nice and accommodating. Would stay here again.

Reviewed on Mar 25, 2026

Opens in a new windowLani Kai Beachfront Resort
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3 out of 5
12600 University Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $124 total per night from Apr 19 to Apr 20
$124 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Neat and clean. Enjoyed our stay.

Reviewed on Mar 24, 2026

Opens in a new windowHilton Garden Inn Ft Myers
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4 out of 5
17260 Harbour Pointe Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$380 nightly
The price is $424 total per night from Apr 12 to Apr 13
$424 total
Apr 12 - Apr 13
Total with taxes and fees
A full-service spa, 4 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the 5 outdoor tennis courts and indoor pool, and unwind ...
Really enjoyed our stay, rooms were clean and amenities were great!

Reviewed on Mar 23, 2026

Opens in a new windowMarriott Sanibel Harbour Resort & Spa
Hyatt Place Fort Myers/at The Forum

Hyatt Place Fort Myers/at The Forum

3 out of 5
2600 Champion Ring Rd Fort Myers FL
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $133 total per night from Apr 5 to Apr 6
$133 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
The room had a dead bug in the restroom and wad of long hair in a clot on the floor. Of our 8 day stay, the cleaning staff only cleaned our room 3 nights, which I was not happy about. We gad to go to the front desk for towels and toilet paper, due to this. For the $2500 price tag, I would expect ...

Reviewed on Mar 24, 2026

Opens in a new windowHyatt Place Fort Myers/at The Forum
Baymont by Wyndham Fort Myers Central

Baymont by Wyndham Fort Myers Central

2.5 out of 5
4850 S Cleveland Ave Fort Myers FL
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $100 total per night from Apr 1 to Apr 2
$100 total
Apr 1 - Apr 2
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
our room wasnt that clean. the breakfast is a joke.

Reviewed on Mar 25, 2026

Opens in a new windowBaymont by Wyndham Fort Myers Central
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Matlacha Isles Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Matlacha Isles area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Matlacha Isles to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Matlacha Isles are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

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