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Top hotels in South Main

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$241 nightly
The price is $282 total per night from Jul 7 to Jul 8
$282 total
Jul 7 - Jul 8
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
"The staff were very helpful and kind. The room was very unique and clean. The bed was perfect."

Reviewed on Jul 5, 2026

Opens in a new windowHotel Zaza Houston Museum District
Marriott Marquis Houston

Marriott Marquis Houston

4 out of 5
1777 Walker Street Houston TX
Fully refundableReserve now, pay when you stay
$223 nightly
The price is $261 total per night from Jul 30 to Jul 31
$261 total
Jul 30 - Jul 31
Total with taxes and fees
A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"Excellent hotel, awesome rooftop pool, great vibe"

Reviewed on Jul 6, 2026

Opens in a new windowMarriott Marquis Houston
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $172 total per night from Jul 12 to Jul 13
$172 total
Jul 12 - Jul 13
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
"We stayed for the world cup game, morocco against Canada , big up to the staff! We has wonderful stay"

Reviewed on Jul 6, 2026

Opens in a new windowBlossom Hotel Houston, Curio Collection by Hilton
The Moran CITYCENTRE

The Moran CITYCENTRE

4 out of 5
800 Sorella Court Houston TX
Fully refundableReserve now, pay when you stay
$204 nightly
The price is $239 total per night from Jul 12 to Jul 13
$239 total
Jul 12 - Jul 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Great property with many good restaurants within 1-5 minutes walking distance"

Reviewed on Jul 6, 2026

Opens in a new windowThe Moran CITYCENTRE
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Jul 15 to Jul 16
$110 total
Jul 15 - Jul 16
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"Thanks to you, I had a good time."

Reviewed on Jul 5, 2026

Opens in a new windowClub Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $148 total per night from Jul 31 to Aug 1
$148 total
Jul 31 - Aug 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...
"The room where very clean and staff were very nice and helpful"

Reviewed on Jul 5, 2026

Opens in a new windowDoubleTree by Hilton Hotel & Suites Houston by the Galleria
Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $125 total per night from Jul 13 to Jul 14
$125 total
Jul 13 - Jul 14
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...
"Good bar. Pool and room not too clean."

Reviewed on Jul 5, 2026

Opens in a new windowGrand Tuscany Hotel
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

3 out of 5
15510 JFK Blvd Houston TX
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $93 total per night from Jul 12 to Jul 13
$93 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport ...
"I booked for two nights stay Fri night and Saturday night. As my flight was only arriving at 5am on Saturday morning I booked Fri night also so that I could check in immediately on arrival. I messaged the property of this and got as n acknowledgment and phone no to call on arrival. Despite this my ..."

Reviewed on Jul 6, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Houston Bush IAH South
Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $104 total per night from Aug 6 to Aug 7
$104 total
Aug 6 - Aug 7
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Hotel was fine, but I think its a little outdated. Loved the fact that was walking distance to the stadium."

Reviewed on Jul 6, 2026

Opens in a new windowWyndham Houston near NRG Park/Medical Center
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

South Main Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on South Main area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near South Main to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near South Main are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent South Main hotel reviews by fellow wanderers

Marriott Marquis Houston

Marriott Marquis Houston

5 out of 5
Posted 7 hours ago
Travelocity Verified Review
"Excellent hotel, awesome rooftop pool, great vibe"
A verified traveler stayed at Marriott Marquis Houston
Marriott Marquis Houston

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