Explore top 2025 5 Star Hotels in Upstate New York

Name: Curtiss Hotel, an Ascend Collection Hotel
Price range: $256 total
Rating: 9.2

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Top Upstate New York 5 Star hotels

Curtiss Hotel, an Ascend Collection Hotel

210 Franklin St, Buffalo, NY

$219 nightly

$256 total

Oct 26 - Oct 27

Total with taxes and fees

This smoke-free hotel features a full-service spa, hot springs, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free ...

9.2/10 Wonderful! (1,000 reviews)

Our stay was excellent. Room was great we will be back

Reviewed on Oct 19, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Upstate New York Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Upstate New York to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Upstate New York 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Upstate New York before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.