Explore top 2026 4 Star Hotels in Central West End

Name: Ameristar Casino Resort and Spa
Price range: $226 total
Rating: 8.4

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Top Central West End 4 Star hotels

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO

Fully refundableReserve now, pay when you stay

$97 nightly

$115 total

Jan 25 - Jan 26

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...

8.6/10 Excellent! (1,193 reviews)

Wonderful stay

Reviewed on Jan 8, 2026

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$149 nightly

$176 total

Jan 21 - Jan 22

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.4/10 Very Good! (4,046 reviews)

There was still an old coffee pod in the coffee maker. Hotels are creepy and weird. This one wasn’t any different. The view was nice. The beds and bathroom were clean.

Reviewed on Jan 19, 2026

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO

Fully refundableReserve now, pay when you stay

$116 nightly

$135 total

Feb 1 - Feb 2

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (1,000 reviews)

Enjoyable

Reviewed on Jan 3, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

Feb 9 - Feb 10

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,560 reviews)

Great hotel! Art, food and drinks were fantastic

Reviewed on Jan 18, 2026

The Cheshire

6300 Clayton Rd Richmond Heights MO

Fully refundableReserve now, pay when you stay

$126 nightly

$150 total

Jan 25 - Jan 26

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

8.6/10 Excellent! (1,010 reviews)

Loved the themes and the decor. Enjoyed the places to eat and drink without having to drive anywhere. Close to the park with the zoo and art museum.

Reviewed on Jan 19, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$118 nightly

$138 total

Jan 30 - Jan 31

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,066 reviews)

Our check in was flawless as always and the staff was very friendly

Reviewed on Jan 11, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO

Fully refundableReserve now, pay when you stay

$127 nightly

$149 total

Jan 21 - Jan 22

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...

8.8/10 Excellent! (1,053 reviews)

Easy check-

Reviewed on Jan 19, 2026

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$149 nightly

$177 total

Jan 25 - Jan 26

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.2/10 Wonderful! (1,108 reviews)

Amazing rooms that are clean with fantastic views. Valet staff was wonderful and attentive. Check in was a breeze with all the info we needed for our stay. Bartender at restaurant was wonderful and kind.

Reviewed on Jan 4, 2026

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$127 nightly

$148 total

Feb 1 - Feb 2

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.6/10 Excellent! (1,002 reviews)

Nice facility, spacious rooms, clean hotel, located next to Ballpark Village with lots of bars and restaurants

Reviewed on Jan 19, 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Fully refundableReserve now, pay when you stay

$193 nightly

$226 total

Jan 25 - Jan 26

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside ...

8.4/10 Very Good! (1,012 reviews)

Very clean

Reviewed on Jan 16, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.