Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$298 nightly
The price is $327 total per night from Jul 5 to Jul 6
$327 total
Jul 5 - Jul 6
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"Terrific stay"
Reviewed on Jul 3, 2026
Drury Inn & Suites Greenville
10 Carolina Point Pkwy Greenville SC
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $131 total per night from Jul 12 to Jul 13
$131 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Very clean. Great breakfast"
Reviewed on Jul 3, 2026
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $101 total per night from Jul 5 to Jul 6
$101 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Very clean - helpful staff - comfy beds - great breakfast!"
Reviewed on Jul 3, 2026
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
$109 nightly
The price is $120 total per night from Aug 2 to Aug 3
$120 total
Aug 2 - Aug 3
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Location and friendly staff"
Reviewed on Jul 2, 2026
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $172 total per night from Jul 12 to Jul 13
$172 total
Jul 12 - Jul 13
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Great hotel overall. The night we stayed they were booked to capacity and our AC wasn’t working below 75. After being in the heat for a concert, it was really inconvenient."
Reviewed on Jun 30, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$95 nightly
The price is $105 total per night from Aug 2 to Aug 3
$105 total
Aug 2 - Aug 3
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Hard to get house keeping, service desk unhelpful"
Reviewed on Jul 2, 2026
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Jul 26 to Jul 27
$121 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
"Clean quiet"
Reviewed on Jul 2, 2026
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jul 5 to Jul 6
$106 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Great location, great price for room. Beds were super comfy. the room was clean and well stocked with everythingwe needed. The AC was nice & cold! The breakfast was really good with a lot of options. The only complaints which were not too big of a deal, pool needed cleaning (leaves and bugs) and ..."
Reviewed on Jul 3, 2026
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from Aug 3 to Aug 4
$99 total
Aug 3 - Aug 4
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Nice rooms, good locations and breakfast was good"
Reviewed on Jul 1, 2026
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
35 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
Best Western Plus Greenville I-385 Inn & Suites
5 out of 5
Posted 13 hours ago
Travelocity Verified Review
"Very clean - helpful staff - comfy beds - great breakfast!"
A verified traveler stayed at Best Western Plus Greenville I-385 Inn & Suites
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