Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Hotel Hartness
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$225 nightly
The price is $247 total per night from Oct 25 to Oct 26
$247 total
Oct 25 - Oct 26
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
"This property was more than expected, gorgeous, clean and very accommodating! Perfect southern charm 😍"
Reviewed on Oct 3, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$401 nightly
The price is $441 total per night from Oct 11 to Oct 12
$441 total
Oct 11 - Oct 12
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"Fantastic in every way!"
Reviewed on Oct 4, 2026
Mint House Greenville Downtown by Kasa
101 Falls Park Dr Greenville SC
$149 nightly
The price is $164 total per night from Nov 1 to Nov 2
$164 total
Nov 1 - Nov 2
Total with taxes and fees
A 24-hour gym, self parking, and laundry facilities are featured at this apartment. Express check-in and express check-out are also provided.
"Three bedroom and two bath unit was beautiful and within 2-3 minute walking distance of the falls and downtown. Easy to book, and the check-in and check-out instructions was easy. Within 6-8 driving minutes to Bon Secours Wellness Arena. Loved our stay."
Reviewed on Oct 3, 2026
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $129 total per night from Oct 18 to Oct 19
$129 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
"Room was clean and comfortable. Restaurant was surprisingly good. Staff were friendly and efficient."
Reviewed on Oct 4, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$99 nightly
The price is $110 total per night from Oct 18 to Oct 19
$110 total
Oct 18 - Oct 19
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
$108 nightly
The price is $120 total per night from Oct 11 to Oct 12
$120 total
Oct 11 - Oct 12
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $95 total per night from Oct 19 to Oct 20
$95 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
1BR Dog-friendly Home w/ In-unit Laundry
Landrum SC
Free WiFi in public areas is available at this cottage.
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $84 total per night from Oct 18 to Oct 19
$84 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
33 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
Hyatt Place Greenville Downtown
5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Hotel was in a great location. We were able to walk everywhere. The staff were all very friendly and helpful when we asked for restaurant recommendations."
A verified traveler stayed at Hyatt Place Greenville Downtown
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