Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Hotel Hartness
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $252 total per night from Aug 24 to Aug 25
$252 total
Aug 24 - Aug 25
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
"Amazing!"
Reviewed on Aug 16, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$361 nightly
The price is $396 total per night from Sep 8 to Sep 9
$396 total
Sep 8 - Sep 9
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"It was amazing! Check in took a while though. Everyone was waiting around in the lobby for their rooms. We got ours just before 4 pm -which was tight for our 5:30 pm event."
Reviewed on Aug 14, 2026
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $91 total per night from Aug 30 to Aug 31
$91 total
Aug 30 - Aug 31
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Property was decent visually but..BEDS ARE TERRIBLE I MEAN TERRIBLE I NEVER COMPLAINED ABOUT A BED IN 8 years as a Expedia customer.. breakfast was decent.. staff seemed cool not much interaction with them but.. my room was definitely sub par if I must say.. dated.. but it was relatively cheap I ..."
Reviewed on Aug 17, 2026
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $111 total per night from Aug 30 to Aug 31
$111 total
Aug 30 - Aug 31
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Loved it. Always lovely and the staff are wonderful. Clean and great breakfast as usual."
Reviewed on Aug 18, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$90 nightly
The price is $100 total per night from Sep 3 to Sep 4
$100 total
Sep 3 - Sep 4
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Tiny room, bathrooms were bland and not updated. Really 2 star quality , motel 6. Breakfast not included. The only good thing about this hotel is the large lobby. Front desk staff was not pleasant either"
Reviewed on Aug 17, 2026
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $112 total per night from Aug 21 to Aug 22
$112 total
Aug 21 - Aug 22
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"This was the most enjoyable stay I’ve had in Clemson! Everything was great. I will stay here again next year!"
Reviewed on Aug 18, 2026
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $91 total per night from Aug 31 to Sep 1
$91 total
Aug 31 - Sep 1
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $172 total per night from Sep 6 to Sep 7
$172 total
Sep 6 - Sep 7
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Hyatt Place Greenville Downtown
128 East Broad Street Greenville SC
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $148 total per night from Sep 7 to Sep 8
$148 total
Sep 7 - Sep 8
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
29 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
Hilton Greenville
5 out of 5
Posted 7 hours ago
Travelocity Verified Review
"Great location, staff, condition. Thanks. I’ll be back"
A verified traveler stayed at Hilton Greenville
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