Book Hotels in Upstate South Carolina, SC

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Top Upstate South Carolina hotels

Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
Free WiFi in public areas is available at this cottage.
Opens in a new windowWooded Cottage - 3 Mi to Clemson University
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
$287 nightly
The price is $315 total per night from Feb 22 to Feb 23
$315 total
Feb 22 - Feb 23
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
Beautiful as soon you walk in and the rooms were great. Great location.

Reviewed on Feb 7, 2026

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $122 total per night from Feb 28 to Mar 1
$122 total
Feb 28 - Mar 1
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Just a short stay and room was very clean staff was nice.

Reviewed on Feb 16, 2026

Opens in a new windowEmbassy Suites Greenville Golf Resort & Conference Center
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
$149 nightly
The price is $163 total per night from Mar 1 to Mar 2
$163 total
Mar 1 - Mar 2
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Room was great. Staff was very nice.

Reviewed on Feb 8, 2026

Opens in a new windowHyatt Regency Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd Greenville SC
Fully refundable
$91 nightly
The price is $100 total per night from Mar 1 to Mar 2
$100 total
Mar 1 - Mar 2
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
room spotless, less a damage mark on the desk. staff very friendly.

Reviewed on Feb 12, 2026

Opens in a new windowCrowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Mar 1 to Mar 2
$109 total
Mar 1 - Mar 2
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
The room was spotless and it was an overall great experience.

Reviewed on Feb 13, 2026

Opens in a new windowHilton Greenville
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $101 total per night from Feb 18 to Feb 19
$101 total
Feb 18 - Feb 19
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Great stay near the university

Reviewed on Feb 11, 2026

Opens in a new windowBest Western Plus Clemson Hotel & Conference Center
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

3 out of 5
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $103 total per night from Feb 23 to Feb 24
$103 total
Feb 23 - Feb 24
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Room good clean food excellent

Reviewed on Feb 13, 2026

Opens in a new windowHyatt Place Greenville/Haywood
Sleep Inn Spartanburg Southwest

Sleep Inn Spartanburg Southwest

2.5 out of 5
501 South Blackstock Rd Spartanburg SC
Fully refundable
$62 nightly
The price is $69 total per night from Mar 10 to Mar 11
$69 total
Mar 10 - Mar 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
room spotless, great service at the desk

Reviewed on Feb 12, 2026

Opens in a new windowSleep Inn Spartanburg Southwest
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