Explore top 2026 4 Star Hotels in Upstate South Carolina

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
Apr 6 - Apr 7
Tomorrow
Apr 7 - Apr 8
This weekend
Apr 10 - Apr 12
Next weekend
Apr 17 - Apr 19

Top Upstate South Carolina 4 Star hotels

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$288 nightly
The price is $316 total per night from Apr 26 to Apr 27
$316 total
Apr 26 - Apr 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.6/10 Exceptional! (470 reviews)
The property was excellently maintained!

Reviewed on Apr 2, 2026

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Hotel Hartness

Hotel Hartness

4 out of 5
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$209 nightly
The price is $230 total per night from Apr 26 to Apr 27
$230 total
Apr 26 - Apr 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
9.8/10 Exceptional! (690 reviews)
Easy direction to get to the location & love then butler that opened the door and greeted me.

Reviewed on Apr 4, 2026

Opens in a new windowHotel Hartness
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
$199 nightly
The price is $221 total per night from Apr 12 to Apr 13
$221 total
Apr 12 - Apr 13
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...
Opens in a new windowThe Shepherd Hotel Downtown Clemson
Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

4 out of 5
101 Falls Park Dr Greenville SC
$104 nightly
The price is $114 total per night from May 4 to May 5
$114 total
May 4 - May 5
Total with taxes and fees
A 24-hour gym, self parking, and laundry facilities are featured at this apartment. Express check-in and express check-out are also provided.
9.2/10 Wonderful! (808 reviews)
Excellent

Reviewed on Apr 3, 2026

Opens in a new windowMint House Greenville Downtown by Kasa
The Westin Poinsett Greenville

The Westin Poinsett Greenville

4 out of 5
120 South Main St Greenville SC
Fully refundableReserve now, pay when you stay
$209 nightly
The price is $230 total per night from May 3 to May 4
$230 total
May 3 - May 4
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...
9.2/10 Wonderful! (1,002 reviews)
Wonderful location for downtown walks

Reviewed on Apr 5, 2026

Opens in a new windowThe Westin Poinsett Greenville
Greenville Marriott

Greenville Marriott

4 out of 5
One Parkway E Greenville SC
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $139 total per night from Apr 19 to Apr 20
$139 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, ...
8.6/10 Excellent! (636 reviews)
Clean rooms, great atmosphere

Reviewed on Mar 29, 2026

Opens in a new windowGreenville Marriott
The Abernathy of Clemson

The Abernathy of Clemson

4 out of 5
157 Old Greenville Hwy Clemson SC
$177 nightly
The price is $197 total per night from Apr 14 to Apr 15
$197 total
Apr 14 - Apr 15
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...
9.6/10 Exceptional! (585 reviews)
Amazing hotel, amazing location. Highly recommended.

Reviewed on Apr 3, 2026

Opens in a new windowThe Abernathy of Clemson
The Station by Compo Hotels

The Station by Compo Hotels

4 out of 5
745 Old Buncombe Rd Travelers Rest SC
$289 nightly
The price is $318 total per night from Apr 7 to Apr 8
$318 total
Apr 7 - Apr 8
Total with taxes and fees
This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Barbecue grills are provided for your convenience.
10/10 Exceptional! (19 reviews)
Swamp rabbit trail and restaurants very close

Reviewed on Apr 2, 2026

Opens in a new windowThe Station by Compo Hotels
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

4 out of 5
621 S Mechanic St Pendleton SC
$186 nightly
The price is $206 total per night from Apr 16 to Apr 17
$206 total
Apr 16 - Apr 17
Total with taxes and fees
This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free full breakfast each morning. A garden, express ...
10/10 Exceptional! (87 reviews)
The property is curated to perfection. The gardens, the living areas, everything. The host, Angela, is so nice, friendly and kind. The room was decorated nicely. The phone chargers, the sound machine! Love! The breakfast was amazing. I needed a reset and this gave it to me.

Reviewed on Mar 27, 2026

Opens in a new windowLiberty Hall Bed and Breakfast
Hotel Domestique

Hotel Domestique

4 out of 5
10 Road of Vines Travelers Rest SC
$429 nightly
The price is $472 total per night from May 5 to May 6
$472 total
May 5 - May 6
Total with taxes and fees
This hotel features a restaurant, an outdoor tennis court, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like cooked-to-order breakfast and ...
Opens in a new windowHotel Domestique
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Upstate South Carolina

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Upstate South Carolina 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Upstate South Carolina will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Upstate South Carolina, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Drury Inn & Suites Greenville

Drury Inn & Suites Greenville

5 out of 5
Posted 13 hours ago
Travelocity Verified Review
"Hot tub was nice and beds were comfy "
A verified traveler stayed at Drury Inn & Suites Greenville
Drury Inn & Suites Greenville

Explore More Ways to Travel with Travelocity