Explore top 2026 4 Star Hotels in Upstate South Carolina

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Top Upstate South Carolina 4 Star hotels

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $273 total per night from Jul 5 to Jul 6
$273 total
Jul 5 - Jul 6
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.6/10 Exceptional! (503 reviews)
"Great room in a beautiful facility!"

Reviewed on Jun 5, 2026

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $169 total per night from Jun 16 to Jun 17
$169 total
Jun 16 - Jun 17
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...
9.8/10 Exceptional! (813 reviews)
"Great place to stay"

Reviewed on Jun 7, 2026

Opens in a new windowThe Shepherd Hotel Downtown Clemson
Hotel Hartness

Hotel Hartness

4 out of 5
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$219 nightly
The price is $241 total per night from Jun 21 to Jun 22
$241 total
Jun 21 - Jun 22
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
9.8/10 Exceptional! (733 reviews)
"This was a home large home at one point they added on additional wing. It’s southern country charm boutique hotel in the neighborhood of an up and coming expensive housing development"

Reviewed on Jun 7, 2026

Opens in a new windowHotel Hartness
Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

4 out of 5
101 Falls Park Dr Greenville SC
$129 nightly
The price is $142 total per night from Jul 8 to Jul 9
$142 total
Jul 8 - Jul 9
Total with taxes and fees
A 24-hour gym, self parking, and laundry facilities are featured at this apartment. Express check-in and express check-out are also provided.
9.2/10 Wonderful! (835 reviews)
"The location was close to a lot of restaurants and activities."

Reviewed on Jun 7, 2026

Opens in a new windowMint House Greenville Downtown by Kasa
The Westin Poinsett Greenville

The Westin Poinsett Greenville

4 out of 5
120 South Main St Greenville SC
Fully refundableReserve now, pay when you stay
$180 nightly
The price is $198 total per night from Jun 14 to Jun 15
$198 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...
9.2/10 Wonderful! (1,006 reviews)
"Great location. Comfortable stay."

Reviewed on Jun 7, 2026

Opens in a new windowThe Westin Poinsett Greenville
Greenville Marriott

Greenville Marriott

4 out of 5
One Parkway E Greenville SC
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $145 total per night from Jun 29 to Jun 30
$145 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, ...
Opens in a new windowGreenville Marriott
The Abernathy of Clemson

The Abernathy of Clemson

4 out of 5
157 Old Greenville Hwy Clemson SC
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $149 total per night from Jul 1 to Jul 2
$149 total
Jul 1 - Jul 2
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...
9.6/10 Exceptional! (604 reviews)
"Loved this hotel, location, staff, amenities, all A+"

Reviewed on Jun 8, 2026

Opens in a new windowThe Abernathy of Clemson
Doubletree By Hilton Greenville Airport

Doubletree By Hilton Greenville Airport

4 out of 5
125 The Parkway Greer SC
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $118 total per night from Jun 30 to Jul 1
$118 total
Jun 30 - Jul 1
Total with taxes and fees
A 24-hour gym is available at this hotel. Take advantage of the free self parking.
10/10 Exceptional! (5 reviews)
"The staff was polite and accommodating, especially the woman in the breakfast bar. The room was clean and quiet."

Reviewed on May 25, 2026

Opens in a new windowDoubletree By Hilton Greenville Airport
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

4 out of 5
621 S Mechanic St Pendleton SC
$183 nightly
The price is $203 total per night from Jun 18 to Jun 19
$203 total
Jun 18 - Jun 19
Total with taxes and fees
This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free full breakfast each morning. A garden, express ...
10/10 Exceptional! (90 reviews)
"This was my second stay at Liberty Hall and it honestly doesn’t get better than this. Quiet, great location, friendly … but the star was my breakfast. Not an understatement- two of the best breakfasts I’ve ever had. Unique dishes, flavor packed, healthy. Our room was clean, the property was clean ..."

Reviewed on Jun 7, 2026

Opens in a new windowLiberty Hall Bed and Breakfast
Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek

4 out of 5
3000 Daventry Cir Greer SC
This apartment features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...
Opens in a new windowLanding Apartments Greer - Sugar Creek
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4 Star Hotels Upstate South Carolina

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Upstate South Carolina 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Upstate South Carolina will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Upstate South Carolina, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Upstate South Carolina hotel reviews by fellow wanderers

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