Explore the best 2025 4 Star Hotels Hotels in Upstate South Carolina

Top Upstate South Carolina 4 Star hotels

The Shepherd Hotel Downtown Clemson

110 Sloan St, Clemson, SC

Free Cancellation

Reserve now, pay when you stay

$189 nightly

$210 total

Aug 3 - Aug 4

Total includes taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also offered.

Pet friendly

Free WiFi

Grand Bohemian Lodge Greenville, Autograph Collection

44 EAST CAMPERDOWN WAY, Greenville, SC

Free Cancellation

Reserve now, pay when you stay

$242 nightly

$266 total

Aug 17 - Aug 18

Total includes taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free WiFi. Valet parking, a garden, and a lobby fireplace are also offered.

Spa

Pet friendly

The Westin Poinsett Greenville

120 South Main St, Greenville, SC

Free Cancellation

Reserve now, pay when you stay

$179 nightly

$197 total

Aug 3 - Aug 4

Total includes taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. Valet parking, a coffee shop, and a grocery/convenience store are also offered.

Free airport shuttle

Pet friendly

Mint House Greenville - Downtown

101 Falls Park Dr, Greenville, SC

$128 nightly

$140 total

Aug 17 - Aug 18

Total includes taxes and fees

A 24-hour gym is featured at this apartment, along with express check-in and express check-out. Laundry facilities are provided for your convenience.

Kitchen

Washer

Hotel Hartness

120 Halston Avenue, Greenville, SC

Free Cancellation

Reserve now, pay when you stay

$220 nightly

$242 total

Aug 17 - Aug 18

Total includes taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and free perks like full breakfast and free self parking. There's a bar/lounge on site, and concierge services and wedding services are also provided.

Pool

Breakfast included

Greenville Marriott

One Parkway E, Greenville, SC

Free Cancellation

Reserve now, pay when you stay

$135 nightly

$149 total

Jul 31 - Aug 1

Total includes taxes and fees

This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, and free airport shuttle. Relax with a drink at the bar/lounge and enjoy perks like free self parking.

Pool

Free airport shuttle

The Abernathy of Clemson

157 Old Greenville Hwy, Clemson, SC

Free Cancellation

Reserve now, pay when you stay

$156 nightly

$174 total

Aug 25 - Aug 26

Total includes taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self parking, express check-in, and dry cleaning are also offered.

Pet friendly

Parking included

Barsala At The American Spinning Mill Apartments

300 Hammett St, Greenville, SC

Get rates

This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A gym and a virtual front desk are also provided.

Kitchen

Washer

The Station by Compo Hotels

745 Old Buncombe Rd, Travelers Rest, SC

$261 nightly

$288 total

Jul 29 - Jul 30

Total includes taxes and fees

This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Barbecue grills are provided for your convenience.

Kitchen

Washer

Liberty Hall Bed and Breakfast

621 S Mechanic St, Pendleton, SC

$201 nightly

$223 total

Aug 4 - Aug 5

Total includes taxes and fees

This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free full breakfast each morning. A garden, express check-in, and express check-out are also on offer.

Breakfast included

Parking included

Hotel Domestique

10 Road of Vines, Travelers Rest, SC

$419 nightly

$461 total

Jul 28 - Jul 29

Total includes taxes and fees

This hotel features a restaurant, an outdoor tennis court, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like cooked-to-order breakfast and free self parking. Enjoy the sauna and conveniences like a 24-hour front desk and laundry facilities.

Pool

Breakfast included

Southern Sunshine Retreat

901 Huntington Rd, Easley, Sc 29642, Usa, Easley, SC

Get rates

This vacation home includes free WiFi in public areas and barbecue grills.

Kitchen

Washer

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Upstate South Carolina

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Upstate South Carolina 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Upstate South Carolina will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Upstate South Carolina, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Upstate South Carolina hotels essential information

Accommodation	2,787 hotels
Lowest Price	$140
Highest Price	$461
Popular hotels	The Shepherd Hotel Downtown Clemson, Grand Bohemian Lodge Greenville, Autograph Collection, The Westin Poinsett Greenville, Mint House Greenville - Downtown, Hotel Hartness, Greenville Marriott, The Abernathy of Clemson, Barsala At The American Spinning Mill Apartments, The Station by Compo Hotels, Liberty Hall Bed and Breakfast, Hotel Domestique, Southern Sunshine Retreat

Recent Upstate South Carolina hotel reviews by fellow wanderers

Woodspring Suites Greenville Airport

5 out of 5

Posted 1 day ago

Travelocity Verified Review

"It is more than worth the price considering the location within just a few minutes from downtown. The room has everything you need to cook your own meal or warm up food and to store your items that may need refrigeration. I have nothing but compliments. I have stayed at worse places that were not worth the price I paid. This places tops them by far. "

A verified traveler stayed at Woodspring Suites Greenville Airport