Book Hotels in Upstate South Carolina, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
May 11 - May 12
Tomorrow
May 12 - May 13
This weekend
May 15 - May 17
Next weekend
May 22 - May 24

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Upstate South Carolina hotels

Hotel Hartness

Hotel Hartness

4 out of 5
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$209 nightly
The price is $230 total per night from May 27 to May 28
$230 total
May 27 - May 28
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
Beautiful property

Reviewed on May 8, 2026

Opens in a new windowHotel Hartness
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$361 nightly
The price is $396 total per night from May 31 to Jun 1
$396 total
May 31 - Jun 1
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
The hotel is centrally located- the staff is attentive, they love my dog!!! The place is clean and the outdoor bar is lovely. Would definitely recommend-

Reviewed on May 9, 2026

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $92 total per night from May 31 to Jun 1
$92 total
May 31 - Jun 1
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
El personal muy amable

Reviewed on May 9, 2026

Opens in a new windowBest Western Plus Greenville I-385 Inn & Suites
Hyatt Place Greenville Downtown

Hyatt Place Greenville Downtown

3 out of 5
128 East Broad Street Greenville SC
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $149 total per night from May 25 to May 26
$149 total
May 25 - May 26
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
I had a pleasant stay. The staff was friendly and helpful. Room was nice and clean and I had a city view, which was great. The only downside (and it's not that extreme) was their breakfast. It wasn't bad but just not may choices. I just prefer hot breakfast if I'm going to eat. I would definitely ...

Reviewed on May 10, 2026

Opens in a new windowHyatt Place Greenville Downtown
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $131 total per night from May 24 to May 25
$131 total
May 24 - May 25
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Everything was awesome

Reviewed on May 10, 2026

Opens in a new windowEmbassy Suites Greenville Golf Resort & Conference Center
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $163 total per night from May 17 to May 18
$163 total
May 17 - May 18
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
The hotel is somewhat outdated 70’s - 80’s era could use a makeover. The staff is incredible and definitely the strong point of the hotel. Location is great, Greenville is on the rise very safe and clean lots of great businesses retail and restaurant. I once felt this way about Asheville but it lost ...

Reviewed on May 10, 2026

Opens in a new windowHyatt Regency Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd Greenville SC
Fully refundable
$105 nightly
The price is $116 total per night from May 17 to May 18
$116 total
May 17 - May 18
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Great

Reviewed on May 10, 2026

Opens in a new windowCrowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $117 total per night from May 24 to May 25
$117 total
May 24 - May 25
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Great stay

Reviewed on May 10, 2026

Opens in a new windowHilton Greenville
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $122 total per night from May 13 to May 14
$122 total
May 13 - May 14
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Very accommodating

Reviewed on May 8, 2026

Opens in a new windowBest Western Plus Clemson Hotel & Conference Center
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

2 out of 5
Posted 5 hours ago
Travelocity Verified Review
"I will say the most important part was the bed was comfortable. After a long trip that was definitely welcomed. The room seemed a little dated and paint was peeling all over the door to the bathroom. The room was clean and the staff was friendly, but it was incredibly noisy for the money it’s worth it I suppose."
A verified traveler stayed at Comfort Inn Greenville - Haywood Mall
Comfort Inn Greenville - Haywood Mall

Explore More Ways to Travel with Travelocity