Book Hotels in Upstate South Carolina, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
Mar 26 - Mar 27
Tomorrow
Mar 27 - Mar 28
This weekend
Mar 27 - Mar 29
Next weekend
Apr 3 - Apr 5

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Upstate South Carolina hotels

Hotel Hartness

Hotel Hartness

4 out of 5
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $219 total per night from Apr 5 to Apr 6
$219 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
Relaxing and beautiful property with many areas to explore, inside& out.

Reviewed on Mar 25, 2026

Opens in a new windowHotel Hartness
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$349 nightly
The price is $383 total per night from Mar 29 to Mar 30
$383 total
Mar 29 - Mar 30
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
Yes, very

Reviewed on Mar 21, 2026

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Drury Inn & Suites Greenville

Drury Inn & Suites Greenville

3 out of 5
10 Carolina Point Pkwy Greenville SC
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $126 total per night from Apr 4 to Apr 5
$126 total
Apr 4 - Apr 5
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Everything was great

Reviewed on Mar 23, 2026

Opens in a new windowDrury Inn & Suites Greenville
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $93 total per night from Apr 5 to Apr 6
$93 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Nice friendly staff, clean rooms, very efficient! Will use this location again!

Reviewed on Mar 23, 2026

Opens in a new windowBest Western Plus Greenville I-385 Inn & Suites
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $107 total per night from Apr 5 to Apr 6
$107 total
Apr 5 - Apr 6
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Clean room.

Reviewed on Mar 24, 2026

Opens in a new windowEmbassy Suites Greenville Golf Resort & Conference Center
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $163 total per night from Apr 5 to Apr 6
$163 total
Apr 5 - Apr 6
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Check in was easy. Front desk staff was very friendly.

Reviewed on Mar 24, 2026

Opens in a new windowHyatt Regency Greenville
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Apr 12 to Apr 13
$109 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Property was very clean throughout stay. Very convenient to getting on/off highway. Minutes from downtown

Reviewed on Mar 25, 2026

Opens in a new windowHilton Greenville
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $115 total per night from Apr 3 to Apr 4
$115 total
Apr 3 - Apr 4
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Everything was nice

Reviewed on Mar 24, 2026

Opens in a new windowBest Western Plus Clemson Hotel & Conference Center
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

3 out of 5
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $101 total per night from Apr 2 to Apr 3
$101 total
Apr 2 - Apr 3
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
My only complaint was really the noise and not as clean as I would have expected it to be, air conditioning unit was not very powerful and made it very stuffy and no air circulation so it kind of smelled funky, but overall it was a good stay

Reviewed on Mar 25, 2026

Opens in a new windowHyatt Place Greenville/Haywood
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

3 out of 5
Posted 12 hours ago
Travelocity Verified Review
"My only complaint was really the noise and not as clean as I would have expected it to be, air conditioning unit was not very powerful and made it very stuffy and no air circulation so it kind of smelled funky, but overall it was a good stay "
A verified traveler stayed at Hyatt Place Greenville/Haywood
Hyatt Place Greenville/Haywood

Explore More Ways to Travel with Travelocity