Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Wooded Cottage - 3 Mi to Clemson University
Clemson SC
Free WiFi in public areas is available at this cottage.
Homewood Suites by Hilton Greenville Downtown
950 South Main Street Greenville SC
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $135 total per night from Jan 1 to Jan 2
$135 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Beautiful hotel
Reviewed on Dec 21, 2025
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$322 nightly
The price is $355 total per night from Jan 15 to Jan 16
$355 total
Jan 15 - Jan 16, 2026
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
The hotel was beautiful. The room was clean. The water pressure in the shower was very low. It took quite a while for the hot water to come. The breakfast was mediocre. Coffee was cold. None of the breakfast was really hot. Location is fantastic.
Reviewed on Dec 15, 2025
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $84 total per night from Dec 28 to Dec 29
$84 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Parking was easy, staff was very pleasant and accommodating. Breakfast was better than most hotels we have stayed in on past trips.
Reviewed on Dec 19, 2025
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $108 total per night from Jan 4 to Jan 5
$108 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Classey hotel, great suite, fabulous breakfast with an omelette station!! Great price too
Reviewed on Dec 20, 2025
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Jan 1 to Jan 2
$153 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Great staff and the valet is awesome. Very courteous and accommodating
Reviewed on Dec 21, 2025
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
11 Ketron Court Greenville SC
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $85 total per night from Dec 29 to Dec 30
$85 total
Dec 29 - Dec 30
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free breakfast and free WiFi. Traveling on business? Take advantage of the 24-hour business center and ...
Clean room nice staff
Reviewed on Dec 24, 2025
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $110 total per night from Dec 29 to Dec 30
$110 total
Dec 29 - Dec 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Awesome and super clean
Reviewed on Dec 19, 2025
Best Western Greenville Airport Inn
5009 Pelham Road Greenville SC
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $75 total per night from Dec 29 to Dec 30
$75 total
Dec 29 - Dec 30
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Free perks include full breakfast, free self parking, and a roundtrip airport shuttle. A 24-hour business ...
Good
Reviewed on Dec 18, 2025
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
11 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Room clean, we had a 15 ft U-Haul towing a vehicle and the property was safe, the staff was friendly breakfast was good"
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
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