Book Hotels in Prairie Home, MO
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Prairie Home hotels

Drury Plaza Hotel Columbia East
3100 Interstate 70 Dr. SE, Columbia, MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Nov 2 to Nov 3
$106 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Great"
Reviewed on Oct 8, 2025

Country Inn & Suites by Radisson, Columbia, MO
817 N Keene St, Columbia, MO
Fully refundable
$83 nightly
The price is $93 total per night from Nov 2 to Nov 3
$93 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Stayed in town for an early morning appointment. This place was a great stay for the price. Rooms were clean!"
Reviewed on Oct 11, 2025

Wingate by Wyndham - Columbia
3101 Wingate Ct, Columbia, MO
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $104 total per night from Oct 21 to Oct 22
$104 total
Oct 21 - Oct 22
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
"Staff was very helpful, prompt and professional. Great place to stay."
Reviewed on Oct 10, 2025

Best Western Plus Columbia Inn
2904 Clark Lane, Columbia, MO
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $81 total per night from Oct 20 to Oct 21
$81 total
Oct 20 - Oct 21
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
"Other than traffic noise from the big highway, a very good stay in all areas."
Reviewed on Oct 7, 2025

Stoney Creek Hotel Columbia
2601 S Providence Rd, Columbia, MO
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $134 total per night from Nov 2 to Nov 3
$134 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling for business? Take advantage of the free WiFi in public areas, laundry service, and conference ...
"N/A"
Reviewed on Oct 8, 2025

Wyndham Executive Center Columbia
2200 I-70 Drive SW, Columbia, MO
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $121 total per night from Nov 2 to Nov 3
$121 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Staff was great and bed was awesome. They don’t have local cable for some reason, but adding that would be great"
Reviewed on Oct 10, 2025

Baymont by Wyndham Columbia, MO
2500 I 70 Dr Sw, Columbia, MO
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $69 total per night from Nov 2 to Nov 3
$69 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Room was clean, well taken care of, reasonably priced, staff great, checkin and out very smoothly and effectively done."
Reviewed on Oct 11, 2025

Ramada by Wyndham Columbia
901 Conley Rd, Columbia, MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Oct 15 to Oct 16
$72 total
Oct 15 - Oct 16
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Clean room. Next to lots of businesses. Sufficient breakfast."
Reviewed on Oct 8, 2025

Quality Inn & Suites Columbia I-70
801 Keene St, Columbia, MO
Fully refundableReserve now, pay when you stay
$62 nightly
The price is $70 total per night from Oct 19 to Oct 20
$70 total
Oct 19 - Oct 20
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Business travelers can take advantage of the free WiFi in public areas. Guests will appreciate ...
"Quiet it was great"
Reviewed on Oct 8, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Prairie Home hotel reviews by fellow wanderers

Baymont by Wyndham Columbia, MO
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Room was clean, well taken care of, reasonably priced, staff great, checkin and out very smoothly and effectively done."
A verified traveler stayed at Baymont by Wyndham Columbia, MO
Explore More Ways to Travel with Travelocity
- Hotels near Faurot Field at Memorial Stadium
- Hotels near Main Street Baptist Church
- Hotels near Stephens College
- Apartments in Columbia
- B&B in Columbia
- Cabins in Columbia
- Condos in Columbia
- Casino Resorts & in Columbia
- Cheap Hotels in Columbia
- Kid Friendly Hotels in Columbia
- Golf Resorts & in Columbia
- Hotels with Hot Tubs in Columbia
- Hotels with an Indoor Pool in Columbia
- Luxury Hotels in Columbia
- Pet Friendly Hotels in Columbia
- Columbia Hotels
- Motels in Columbia
- Hotels near Rock Bridge Memorial State Park
- Hotels near Women's and Children's Hospital
- Windsor Place Hotels
- Hotels near Daniel Boone Regional Library
- B&B in New Franklin
- Casino Resorts & in New Franklin
- New Franklin Hotels
- Motels in New Franklin
- Speed Hotels
- Apartments in Boonville
- B&B in Boonville
- Condos in Boonville
- Extended Stay Hotels in Boonville
- Guest Houses in Boonville
- Adventure Hotels in Boonville
- Convention Center Hotels in Boonville
- Hotels with Bar in Boonville
- Hotels with Free Parking in Boonville
- Hotels with Hot Tubs in Boonville
- Luxury Hotels in Boonville
- Pet Friendly Hotels in Boonville
- Romantic Getaways & Hotels in Boonville
- Spa Resorts & in Boonville
- Hotel Wedding Venues Hotels in Boonville
- Boonville Hotels
- Motels in Boonville
- Lupus Hotels
- Hotels near Lions Park Aquatic Center
- Hotels near Columbia Regional
- Hartsburg Hotels
- Eagle Bluffs Conservation Area Hotels
- Central Missouri Hotels
- Apartments in Wooldridge
- B&B in Wooldridge
- Thornbrook Hotels
- Hotels with Pools in Boone County
- Boone County Hotels
- Hotels near Mizzou Arena
- Hotels near Harley Park
- Hotels near Columbia Mall
- Hotels near Columbia College
- Ashland Hotels
- Tipton Hotels
- Motels in Tipton
- Hotels near University of Missouri
- B&B in California
- Cabins in California
- Hotels with Free Parking in California
- Pet Friendly Hotels in California
- California Hotels
- Vacation Homes in California
- Hotels near Warm Springs Ranch
- Cabins in Rocheport
- Rocheport Hotels
- Vacation Homes in Rocheport
- Hotels near Isle of Capri Casino
- Farmstay in Jamestown
- Cabins in Jamestown
- B&B in Bunceton
- Car rental Columbia
- Luxury Car Rentals in Columbia
- Minivan Car Rentals in Columbia
- Pickup Car Rentals in Columbia
- Van Car Rentals in Columbia
- Car rental New Franklin
- Car rental Boonville
- Minivan Car Rentals in Boonville
- Pickup Car Rentals in Boonville
- Standard Car Rentals in Boonville
- Van Car Rentals in Boonville
- Car rental Tipton
- Van Car Rentals in Tipton
- Car rental California
- Minivan Car Rentals in California