Explore 118 Luxury Hotels in Northeast Missouri

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Best Luxury Hotels in Northeast Missouri

The Ritz-Carlton, St. Louis

100 Carondelet Plaza, St. Louis, MO

Fully refundableReserve now, pay when you stay

$579 nightly

$674 total

Jul 27 - Jul 28

Total includes taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.2/10 Wonderful! (539 reviews)

"Excellent"

Reviewed on Jul 18, 2025

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway, St. Louis, MO

Fully refundableReserve now, pay when you stay

$211 nightly

$249 total

Aug 24 - Aug 25

Total includes taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

8.8/10 Excellent! (1,016 reviews)

"The valet people were amazing. Brenda the hostess was so friendly to talk to!!"

Reviewed on Jul 22, 2025

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue, St. Louis, MO

Fully refundableReserve now, pay when you stay

$94 nightly

$110 total

Aug 3 - Aug 4

Total includes taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...

8.8/10 Excellent! (2,942 reviews)

"This is my favorite hotel ever since I discovered it years ago I must always stay with them. The staff are nice. The rooms are extremely clean and I love their breakfast buffet. They have a parking on the back, which is easy to get to your room from and love that there’s a lot of restaurants ..."

Reviewed on Jul 23, 2025

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St, St. Louis, MO

Fully refundableReserve now, pay when you stay

$103 nightly

$122 total

Aug 18 - Aug 19

Total includes taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...

8.6/10 Excellent! (1,015 reviews)

"The staff was very helpful. The building has a lot of charm. I would stay there again."

Reviewed on Jul 22, 2025

The Westin St. Louis

811 Spruce St, St. Louis, MO

Fully refundableReserve now, pay when you stay

$127 nightly

$148 total

Aug 3 - Aug 4

Total includes taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.4/10 Very Good! (1,012 reviews)

Would recommend

"Check-in was wonderful! The room was spacious and comfortable. The bathroom maybe a little upgrade.. but still comfy! Orlando, the valet was just amazing!!!!! Give that man a raise! The bar staff, well just one man, was kind but not very energetic- (trying to be kind). But- stillWould ..."

Reviewed on Jul 20, 2025

Ameristar Casino Resort and Spa

1 Ameristar Blvd, St. Charles, MO

Fully refundableReserve now, pay when you stay

$183 nightly

$214 total

Aug 10 - Aug 11

Total includes taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside ...

8.2/10 Very Good! (1,017 reviews)

"The hotel room was comfortable and well-kept - it’s a good spot for a weekend getaway or a night before flying out from the airport. Good mix of slots and tables."

Reviewed on Jul 24, 2025

Quincy Inn and Suites

224 N 36th Street, Quincy, IL

Fully refundableReserve now, pay when you stay

$90 nightly

$103 total

Jul 27 - Jul 28

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the express check-in. A grocery/convenience ...

6.8/10 (1,001 reviews)

"The beds were clean but the overall feeling of the hotel was not very clean. We didn’t have a shower curtain which they got for us quickly. The carpets seemed very dirty, but we paid for what we’re got."

Reviewed on Jul 13, 2025

Moberly Inn and Suites

1200 Highway 24 East, Moberly, MO

This luxury hotel features 2 restaurants, a bar/lounge, and an outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public ...

"We did not stay there the motel was condemed The website needs to be took down"

Reviewed on Nov 12, 2018

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More 4 star hotels in Northeast Missouri

River City Casino & Hotel

777 River City Casino Blvd, St. Louis, MO

$132 nightly

$154 total

Aug 3 - Aug 4

Total includes taxes and fees

9/10 Wonderful! (1,297 reviews)

5 star hotels in Northeast Missouri

The Ritz-Carlton, St. Louis

100 Carondelet Plaza, St. Louis, MO

$579 nightly

$674 total

Jul 27 - Jul 28

Total includes taxes and fees

9.2/10 Wonderful! (539 reviews)

Northeast Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Northeast Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Northeast Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Northeast Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Northeast Missouri, and plan your next opulent escape.

Northeast Missouri hotels essential information

Accommodation	2,770 hotels
Lowest Price	$103
Highest Price	$674
Popular hotels	The Royal Sonesta Chase Park Plaza St. Louis, Ameristar Casino Resort and Spa, The Ritz-Carlton, St. Louis, Moberly Inn and Suites, Quincy Inn and Suites, Clayton Plaza Hotel & Extended Stay, The Westin St. Louis, Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Popular Luxury Stays in Northeast Missouri

5 Stars Luxury stays in Northeast Missouri

Luxury stays in Northeast Missouri with spa

Recent Northeast Missouri Hotel Reviews By Fellow Wanderers

Renaissance St. Louis Airport Hotel

5 out of 5

Posted 1 day ago

Travelocity Verified Review

"The staff was great but the server we had at the restaurant was phenomenal and we will be back soon."

A verified traveler stayed at Renaissance St. Louis Airport Hotel

Pear Tree Inn St. Louis Near Union Station

5 out of 5

Posted 2 days ago

Travelocity Verified Review

"This is the second time I've stayed here this year, and again I am 100% satisfied. The people (especially Quincy and Doris) are so helpful and friendly. The facilities are very nice and comfortable. Definitely family friendly. If I find myself in St. Louis again, this is where I will stay."

A verified traveler stayed at Pear Tree Inn St. Louis Near Union Station