Book Hotels in Matlacha Isles-Matlacha Shores, FL
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Top Matlacha Isles-Matlacha Shores hotels

Pink Shell Beach Resort and Marina
275 Estero Blvd Fort Myers Beach FL
$295 nightly
The price is $329 total per night from May 13 to May 14
$329 total
May 13 - May 14
Total with taxes and fees
A marina, 3 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the gym and free buffet breakfast each morning. Enjoy the hot ...
Great breakfast! Great room and balcony view! Great beach with chairs, umbrellas, and cocktail service. Horrible bar staff!! They act like you are bothering them when ordering. And because your tip is automatic, they don’t care about the poor customer service they are providing.
Reviewed on Apr 12, 2026

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
1538 Cape Coral Pkwy E Cape Coral FL
Fully refundable
$101 nightly
The price is $113 total per night from May 10 to May 11
$113 total
May 10 - May 11
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Breakfast was good, coffee was excellent. Everything was fine. A slight inconvenience, the room phone did not work and wifi kept dropping.
Reviewed on Apr 14, 2026

Sanibel Island Beach Resort
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
$262 nightly
The price is $289 total per night from May 7 to May 8
$289 total
May 7 - May 8
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink ...
Very clean, great front desk service, nice restaurant and pool area. Tiki bar was great too. Great proximity to a nice area on the beach.
Reviewed on Apr 14, 2026

Margaritaville Beach Resort Fort Myers
251 Crescent Street Fort Myers Beach FL
$287 nightly
The price is $320 total per night from Apr 28 to Apr 29
$320 total
Apr 28 - Apr 29
Total with taxes and fees
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Relax with a drink at one of the 4 bars/lounges and get perks ...
AMAZING!!!! Rooms were clean and comfortable. Housekeeping was always available. Food-amazing. It is on the high price side, but you get tons of food if you walk-away hungry that is on you. Beach was great, you get 2 chairs with your stay, bar service available for delivery. Staff was so friendly ...
Reviewed on Apr 14, 2026

Lani Kai Beachfront Resort
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $199 total per night from May 4 to May 5
$199 total
May 4 - May 5
Total with taxes and fees
This smoke-free hotel features 3 restaurants, 3 beach bars, and 6 bars/lounges. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Enjoy ...
The Lani Kai looks great after hurricane repairs. The grounds in back, the pool area, and redesigned bars on the ground level look great. Rooms were nice and clean and the staff everywhere were very attentive and accommodating. Jayne in the Sun Deck and Island View restaurant is terrific. She works ...
Reviewed on Apr 14, 2026

Marriott Sanibel Harbour Resort & Spa
17260 Harbour Pointe Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$380 nightly
The price is $424 total per night from Apr 16 to Apr 17
$424 total
Apr 16 - Apr 17
Total with taxes and fees
A full-service spa, 4 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the 5 outdoor tennis courts and indoor pool, and unwind ...
Rooms need upgrading. The amenities are great!
Reviewed on Apr 14, 2026

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
20091 Summerlin Road Fort Myers FL
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $97 total per night from May 3 to May 4
$97 total
May 3 - May 4
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
The bed saved the day. It was a large king and very very comfortable. The room was too dark. Not enough lighting. The free breakfast is minimal. Eggs seemed made from powder.
Reviewed on Apr 14, 2026

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
10150 Daniels Pkwy Fort Myers FL
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $84 total per night from Apr 15 to Apr 16
$84 total
Apr 15 - Apr 16
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Everything
Reviewed on Apr 12, 2026

Baymont by Wyndham Fort Myers Central
4850 S Cleveland Ave Fort Myers FL
Fully refundableReserve now, pay when you stay
$53 nightly
The price is $59 total per night from May 10 to May 11
$59 total
May 10 - May 11
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
Need fixing in the room smell bad too much hanging out
Reviewed on Apr 14, 2026
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Recent Matlacha Isles-Matlacha Shores hotel reviews by fellow wanderers

Sanibel Island Beach Resort
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Very clean, great front desk service, nice restaurant and pool area. Tiki bar was great too. Great proximity to a nice area on the beach. "
A verified traveler stayed at Sanibel Island Beach Resort
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