Book a hotel near Main Street Cultural District, Ames
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top hotels close to Main Street Cultural District

Comfort Inn and Suites Ames near ISU Campus
603 South 16th Street, Ames, IA
Free Cancellation
Reserve now, pay when you stay
1.13 mi from Main Street Cultural District
$86 nightly
The price is $97 total per night
$97 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like full breakfast and free self parking.

GrandStay Hotel & Suites
1606 S Kellogg Ave, Ames, IA
Free Cancellation
Reserve now, pay when you stay
1.22 mi from Main Street Cultural District
$109 nightly
The price is $122 total per night
$122 total
Nov 17 - Nov 18
Total with taxes and fees
This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like on-the-go breakfast and free self parking.

SpringHill Suites by Marriott Ames
1810 SE 16TH STREET, Ames, IA
Free Cancellation
Reserve now, pay when you stay
1.78 mi from Main Street Cultural District
$93 nightly
The price is $104 total per night
$104 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the laundry service. Enjoy the indoor pool and conveniences like a 24-hour front desk and laundry facilities.

Microtel Inn & Suites by Wyndham Ames
2216 Se 16th St, Ames, IA
Free Cancellation
Reserve now, pay when you stay
2.04 mi from Main Street Cultural District
$67 nightly
The price is $75 total per night
$75 total
Nov 17 - Nov 18
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. Enjoy the 24-hour gym and conveniences like a 24-hour front desk and laundry facilities.

Best Western Plus University Park Inn & Suites
2500 University Blvd., Ames, IA
Free Cancellation
Reserve now, pay when you stay
2.05 mi from Main Street Cultural District
$82 nightly
The price is $92 total per night
$92 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Gateway Hotel and Conference Center at Iowa State University
2100 Green Hills Drive, Ames, IA
2.1 mi from Main Street Cultural District
$94 nightly
The price is $106 total per night
$106 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. Enjoy the gym and perks like free self parking.
Pool
Hot Tub

Country Inn & Suites by Radisson, Ames, IA
2605 Se 16th St, Ames, IA
Free Cancellation
2.15 mi from Main Street Cultural District
$84 nightly
The price is $94 total per night
$94 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.
Pool
Hot Tub

Hilton Garden Inn Ames
1325 Dickinson Ave, Ames, IA
Free Cancellation
Reserve now, pay when you stay
3.47 mi from Main Street Cultural District
$99 nightly
The price is $111 total per night
$111 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the gym and perks like free self parking and free WiFi. A 24-hour business center, a terrace, and a garden are also on offer.
Pool
Pet friendly

Qube Hotel
300 Boulder Pointe, Polk City, IA
Free Cancellation
Reserve now, pay when you stay
17.91 mi from Main Street Cultural District
$85 nightly
The price is $95 total per night
$95 total
Nov 12 - Nov 13
Total with taxes and fees
A gym, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. A business center, a terrace, and a garden are also on offer.

Comfort Inn & Suites Ankeny - Des Moines
215 Ne Delaware Ave, Ankeny, IA
Free Cancellation
Reserve now, pay when you stay
20.23 mi from Main Street Cultural District
$82 nightly
The price is $92 total per night
$92 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

Quality Inn & Suites Ankeny - Des Moines
201 Se Delaware Ave, Ankeny, IA
Free Cancellation
Reserve now, pay when you stay
20.4 mi from Main Street Cultural District
$67 nightly
The price is $76 total per night
$76 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.

My Place Hotel - Ankeny/ Des Moines, IA
2506 SE Tones Drive, Ankeny, IA
Free Cancellation
Reserve now, pay when you stay
22.22 mi from Main Street Cultural District
$80 nightly
The price is $90 total per night
$90 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling on business? Take advantage of the 24-hour business center and free internet in public areas. Free parking, a snack bar/deli, and a grocery/convenience store are also offered.
Don't see what you're looking for?
See all available properties in Main Street Cultural District
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Main Street Cultural District hotels essential information
Accommodation | 706 hotels |
|---|---|
Lowest Price | $75 |
Highest Price | $122 |
Popular hotels | Gateway Hotel and Conference Center at Iowa State University, Country Inn & Suites by Radisson, Ames, IA, Comfort Inn and Suites Ames near ISU Campus, GrandStay Hotel & Suites, SpringHill Suites by Marriott Ames, Best Western Plus University Park Inn & Suites, Microtel Inn & Suites by Wyndham Ames, Hilton Garden Inn Ames, Qube Hotel, Comfort Inn & Suites Ankeny - Des Moines, Quality Inn & Suites Ankeny - Des Moines, My Place Hotel - Ankeny/ Des Moines, IA |
Recent Main Street Cultural District hotel reviews by fellow wanderers

Qube Hotel
5 out of 5
Posted 6 days ago
Travelocity Verified Review
"great hotel. clean. friendly and close to Des Moines and Ames"
A verified traveler stayed at Qube Hotel
Explore More Ways to Travel with Travelocity
- Hotels near Hilton Coliseum
- Farmstay in Ames
- Apartments in Ames
- B&B in Ames
- Cabins in Ames
- Cottages in Ames
- Extended Stay Hotels in Ames
- Guest Houses in Ames
- All Inclusive Resorts & in Ames
- Casino Resorts & in Ames
- Cheap Hotels in Ames
- Convention Center Hotels in Ames
- Kid Friendly Hotels in Ames
- Golf Resorts & in Ames
- Historic Hotels in Ames
- Hotels with Pools in Ames
- Hotels with Balconies in Ames
- Hotels with Bar in Ames
- Hotels with Hot Tubs in Ames
- Hotels with an Indoor Pool in Ames
- Hotels with Waterslides in Ames
- Luxury Hotels in Ames
- Motel 6 Hotels in Ames
- Pet Friendly Hotels in Ames
- Romantic Getaways & Hotels in Ames
- Ski Resorts and in Ames
- Spa Resorts & in Ames
- Waterpark Hotels and Resorts in Ames
- Hotel Wedding Venues Hotels in Ames
- Winery Hotels in Ames
- Ames Hotels
- Inns in Ames
- Motels in Ames
- Vacation Homes in Ames
- Boone Hotels
- Hotels near McHose Park
- Hotels near Iowa Arboretum
- Hotels near Iowa State University
- Elkhart Hotels
- Hotels near Brunnier Art Museum
- Hotels near Veenker Memorial Golf Course
- Hotels near Iowa State Center
- Hotels near Center Grove Orchard
- Hotels near Boone Speedway
- Extended Stay Hotels in Cambridge
- Cambridge Hotels
- Motels in Cambridge
- Hotels near Furman Aquatic Center
- Colo Hotels
- Hotels near Ledges State Park
- Hotels near Big Creek State Park
- Mccallsburg Hotels
- B&B in Huxley
- Hotels near Stephens Auditorium
- Hotels near Jack Trice Stadium
- Apartments in Nevada
- Nevada Hotels
- Motels in Nevada
- Hotels near Seven Oaks Recreation
- Hotels near Boone and Scenic Valley Railroad and Museum
- 5 Star Hotels in Story City
- B&B in Story City
- Cheap Hotels in Story City
- Hotels with Pools in Story City
- Hotels with Bar in Story City
- Hotels with Hot Tubs in Story City
- Hotels with Room Service in Story City
- Pet Friendly Hotels in Story City
- Spa Resorts & in Story City
- Story City Hotels
- Hotels near Honey Creek Golf Club
- B&B in Central Iowa
- Cabins in Central Iowa
- All Inclusive Resorts & in Central Iowa
- Casino Resorts & in Central Iowa
- Waterpark Hotels and Resorts in Central Iowa
- Central Iowa Hotels
- Lodges in Central Iowa
- Madrid Hotels
- Hotels near Tournament Club of Iowa
- Hotels near Reiman Gardens
- B&B in Slater
- Slater Hotels





