Book a hotel near Main Street Cultural District, Ames

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Top hotels close to Main Street Cultural District

Comfort Inn and Suites Ames near ISU Campus

Comfort Inn and Suites Ames near ISU Campus

2.5 out of 5
603 South 16th Street Ames IA
Free Cancellation
Reserve now, pay when you stay
1.13 mi from Main Street Cultural District
$82 nightly
The price is $91 total per night
$91 total
Jan 23 - Jan 24, 2026
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like full breakfast and free self parking.
Pool
Breakfast included
SpringHill Suites by Marriott Ames

SpringHill Suites by Marriott Ames

2.5 out of 5
1810 SE 16TH STREET Ames IA
Free Cancellation
Reserve now, pay when you stay
1.78 mi from Main Street Cultural District
$93 nightly
The price is $104 total per night
$104 total
Dec 26 - Dec 27
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the laundry service. Enjoy the indoor pool and conveniences like a 24-hour front desk and laundry facilities.
Pool
Breakfast included
Hampton Inn & Suites Ames

Hampton Inn & Suites Ames

2.5 out of 5
2100 Southeast 16th Street Ames IA
Free Cancellation
Reserve now, pay when you stay
1.96 mi from Main Street Cultural District
$82 nightly
The price is $92 total per night
$92 total
Dec 30 - Dec 31
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. A business center, dry cleaning, and luggage storage are also on offer.
Pool
Breakfast included
Quality Inn & Suites Ames Conference Center Near ISU Campus

Quality Inn & Suites Ames Conference Center Near ISU Campus

2.5 out of 5
2601 E 13th St Ames IA
Free Cancellation
Reserve now, pay when you stay
1.99 mi from Main Street Cultural District
$66 nightly
The price is $73 total per night
$73 total
Dec 30 - Dec 31
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like self-serve breakfast and free self parking.
Pool
Breakfast included
Microtel Inn & Suites by Wyndham Ames

Microtel Inn & Suites by Wyndham Ames

2 out of 5
2216 Se 16th St Ames IA
2.04 mi from Main Street Cultural District
Get rates
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. Enjoy the 24-hour gym and conveniences like a 24-hour front desk and laundry facilities.
Breakfast included
Pet friendly
Best Western Plus University Park Inn & Suites

Best Western Plus University Park Inn & Suites

2.5 out of 5
2500 University Blvd. Ames IA
Free Cancellation
Reserve now, pay when you stay
2.05 mi from Main Street Cultural District
$75 nightly
The price is $84 total per night
$84 total
Dec 25 - Dec 26
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.
Pool
Hot Tub
Baymont by Wyndham Ames

Baymont by Wyndham Ames

2.5 out of 5
1605 S Dayton Ave Ames IA
Free Cancellation
Reserve now, pay when you stay
2.09 mi from Main Street Cultural District
$54 nightly
The price is $60 total per night
$60 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business center. Express check-out is provided and the front desk is staffed around-the-clock.
Breakfast included
Parking included
Gateway Hotel and Conference Center at Iowa State University

Gateway Hotel and Conference Center at Iowa State University

3 out of 5
2100 Green Hills Drive Ames IA
2.1 mi from Main Street Cultural District
$76 nightly
The price is $86 total per night
$86 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. Enjoy the gym and perks like free self parking.
Pool
Hot Tub
Country Inn & Suites by Radisson, Ames, IA

Country Inn & Suites by Radisson, Ames, IA

2.5 out of 5
2605 Se 16th St Ames IA
Free Cancellation
2.15 mi from Main Street Cultural District
$77 nightly
The price is $87 total per night
$87 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.
Pool
Hot Tub
AmericInn by Wyndham Ames

AmericInn by Wyndham Ames

2.5 out of 5
2507 SE 16th St. Ames IA
Free Cancellation
Reserve now, pay when you stay
2.17 mi from Main Street Cultural District
$69 nightly
The price is $77 total per night
$77 total
Dec 25 - Dec 26
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Hot Tub
Hilton Garden Inn Ames

Hilton Garden Inn Ames

3 out of 5
1325 Dickinson Ave Ames IA
Free Cancellation
Reserve now, pay when you stay
3.47 mi from Main Street Cultural District
$84 nightly
The price is $94 total per night
$94 total
Dec 30 - Dec 31
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the gym and perks like free self parking and free WiFi. A 24-hour business center, a terrace, and a garden are also on offer.
Pool
Pet friendly
Sleep Inn & Suites Ames near ISU Campus

Sleep Inn & Suites Ames near ISU Campus

2.5 out of 5
1310 Dickinson Avenue Ames IA
Free Cancellation
3.54 mi from Main Street Cultural District
$62 nightly
The price is $69 total per night
$69 total
Jan 15 - Jan 16, 2026
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.
Pool
Breakfast included
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Main Street Cultural District hotels essential information

Accommodation
761 hotels
Lowest Price
$60
Highest Price
$104
Popular hotels
Gateway Hotel and Conference Center at Iowa State University, Comfort Inn and Suites Ames near ISU Campus, SpringHill Suites by Marriott Ames, Country Inn & Suites by Radisson, Ames, IA, Microtel Inn & Suites by Wyndham Ames, Best Western Plus University Park Inn & Suites, Hampton Inn & Suites Ames, Quality Inn & Suites Ames Conference Center Near ISU Campus, AmericInn by Wyndham Ames, Baymont by Wyndham Ames, Sleep Inn & Suites Ames near ISU Campus, Hilton Garden Inn Ames

Recent Main Street Cultural District hotel reviews by fellow wanderers

Baymont by Wyndham Ames

Baymont by Wyndham Ames

5 out of 5
Posted 4 days ago
Travelocity Verified Review
"The room was clean and updated. The beds were comfortable. That’s important to us. "
A verified traveler stayed at Baymont by Wyndham Ames
Baymont by Wyndham Ames

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