$182 Cheap American Airlines flights from Memphis to Des Moines (MEM to DSM)

Find The Best Day To Fly from Memphis to Des Moines

Amazing American Airlines MEM to DSM Flight Deals

The cheapest flights to Des Moines Intl. found within the past 7 days were $458 round trip and $182 one way. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Can I catch a flight from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport right now?
It's always wise to know about any travel advice reports and quarantine requirements in place in your destination city. Be sure to check out the Covid-19 Travel Advisor for up-to-date info on booking a flight to Des Moines Intl. Airport.
What terminal is American Airlines at MEM?
Once you've been given the boarding pass for your flight from Memphis Intl. Airport (MEM) to DSM, you should be able to identify which terminals American Airlines flies in and out of. If not, contact your carrier or do some online research for that information.
Are there American Airlines non-stop flights from MEM to DSM?
If you're traveling with American Airlines from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM), you'll need to make at least one stop. While you're waiting for your connection, take the chance to pick up a snack or explore the airport shops.
How long is an American Airlines flight from MEM to DSM?
From the minute your American Airlines plane gets pushed back from the gate at MEM to the instant it taxis into Des Moines Intl. Airport (DSM), your plane ride will last around 3 hours and 53 minutes. With such a short and sweet flight time, it's a wonderful spur-of-the-moment escape.
How many direct and indirect flights does American Airlines fly from MEM to DSM?
You can take your pick of 2 American Airlines flights daily from MEM to DSM.
If I am not able to travel due to COVID-19, can I change my booking to a later date?
For more info about changing your flight to Des Moines Intl. Airport (DSM), please visit our Customer Service Portal.
What is the best day to buy a plane ticket?
This just in! Airfares offered on Thursdays tend to be the cheapest, according to flight demand on Travelocity in 2021. Tuesday and Wednesday prices are also good, but you may want to prepare your budget if booking during the weekend, as data shows that is when prices are generally at their highest.
What are the cheapest days to fly?
Frequent travelers may already know this, but earlier in the week can be the cheapest time to fly. In 2021, flights departing on a Monday were generally the cheapest of the week, whereas you may pay a premium for weekend flights when demand is usually high. On average, tickets were most expensive for Saturday departures, so if you need to fly out on a weekend, you might look for deals ahead of time.
How far in advance can you book a flight?
Trying to figure out how early you should book your flight? It's possible to start comparing international airfares on Travelocity up to 12 months in advance. However, it does depend on the carrier as not all airlines release their prices that far out. According to our 2021 flight demand trends, last minute planners can still bag a bargain with some of the cheapest fares appearing 0-2 weeks prior to their travel dates.*According to flight demand on Travelocity.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Discover our best American Airlines flight from Memphis MEM to Des Moines DSM 

To find the best deals on flights to Memphis from Des Moines with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.  

 

Return flights from Memphis MEM to Des Moines DSM with American Airlines 

If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $458 to $639, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply. 

 

Book one-way American Airlines flights from Memphis MEM to Des Moines DSM 

A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Memphis to Des Moines costs from $182. Prices and availability subject to change. Additional terms may apply. 

 

The easy way to find cheap flights to Des Moines DSM from  Memphis MEM with American Airlines 

To find a cheap American Airlines flight from Memphis MEM to Des Moines DSM, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference. 

 

How to find our best airfare deals on American Airlines flights from Memphis MEM to Des Moines DSM 

If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as May, or if you book a flight with a stopover. 

 

Find nonstop flights from Memphis MEM to Des Moines DSM with American Airlines 

If you’re keen to be on Des Moines soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it. 

 

Flexible airline tickets for American Airlines flights from Memphis MEM to Des Moines DSM 

Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.  

 

There are a lot of reasons to book your flights to Des Moines DSM from  Memphis MEM with American Airlines on Travelocity 

At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.

American Airlines Airports
Hop on a(n) American Airlines flight today by flying to many destinations out of these domestic and international airports:
Airport code
Country
Airport name
Number of flights
DFWUSADallas-Fort Worth Intl.599
CLTUSACharlotte-Douglas Intl.536
ORDUSAO'Hare Intl.317
PHLUSAPhiladelphia Intl.247
MIAUSAMiami Intl.193
DCAUSARonald Reagan Washington National152
PHXUSASky Harbor Intl.141
LAXUSALos Angeles Intl.81
LGAUSALaGuardia72
BOSUSALogan Intl.57

Travelers ❤️ these 🏨 after their flight to Des Moines

Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport

2 out of 5
1901 Hackley Ave Des Moines IA
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. ...
8.6/10 Excellent! (1,784 reviews)
Exactly what I needed for the price! Easy and affordable and clean. Did the job great.

Reviewed on May 8, 2026

Days Inn & Suites by Wyndham Des Moines Airport
AmericInn by Wyndham Des Moines Airport

AmericInn by Wyndham Des Moines Airport

3 out of 5
1920 Hackley Ave Des Moines IA
This hotel doesn't skimp on freebies - guests receive free full breakfast, free self parking, and a free airport shuttle. Traveling on business? Take advantage ...
8/10 Very Good! (1,006 reviews)
Clean room good staff nice parking free breakfast good

Reviewed on May 7, 2026

AmericInn by Wyndham Des Moines Airport
Hampton Inn Des Moines-Airport

Hampton Inn Des Moines-Airport

2.5 out of 5
5001 Fleur Dr Des Moines IA
This hotel features a gym and a seasonal outdoor pool. Free perks include continental breakfast, free self parking, and a roundtrip airport shuttle. You'll appreciate ...
8.8/10 Excellent! (1,005 reviews)
Yes everything went great

Reviewed on May 5, 2026

Hampton Inn Des Moines-Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore More Ways to Travel with Travelocity

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.