
$210 Cheap American Airlines flights from Knoxville to Minneapolis (TYS to MSP)
Find The Best Day To Fly from Knoxville to Minneapolis
Amazing American Airlines TYS to MSP Flight Deals
The cheapest flights to Minneapolis - St. Paul Intl. found within the past 7 days were $280 round trip and $210 one way. Prices and availability subject to change. Additional terms may apply.
MSP From TYS Economy Coach Packages on Similar Airlines



Frequently asked questions
Discover our best American Airlines flight from Knoxville TYS to Minneapolis MSP
To find the best deals on flights to Knoxville from Minneapolis with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from Knoxville TYS to Minneapolis MSP with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $280 to $332, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from Knoxville TYS to Minneapolis MSP
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Knoxville to Minneapolis costs from $210. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Minneapolis MSP from Knoxville TYS with American Airlines
To find a cheap American Airlines flight from Knoxville TYS to Minneapolis MSP, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from Knoxville TYS to Minneapolis MSP
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as September, or if you book a flight with a stopover.
Find nonstop flights from Knoxville TYS to Minneapolis MSP with American Airlines
If you’re keen to be on Minneapolis soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from Knoxville TYS to Minneapolis MSP
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Minneapolis MSP from Knoxville TYS with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
Airport code | Country | Airport name | Number of flights |
---|---|---|---|
DFW | USA | Dallas-Fort Worth Intl. | 599 |
CLT | USA | Charlotte-Douglas Intl. | 536 |
ORD | USA | O'Hare Intl. | 317 |
PHL | USA | Philadelphia Intl. | 247 |
MIA | USA | Miami Intl. | 193 |
DCA | USA | Ronald Reagan Washington National | 152 |
PHX | USA | Sky Harbor Intl. | 141 |
LAX | USA | Los Angeles Intl. | 81 |
LGA | USA | LaGuardia | 72 |
BOS | USA | Logan Intl. | 57 |
Travelers ❤️ these 🏨 after their flight to Minneapolis

Hyatt Place Minneapolis Airport-South
Reviewed on Jul 30, 2025

InterContinental Minneapolis - St. Paul Airport by IHG
Reviewed on Jul 27, 2025

Wyndham Bloomington - Mall of America
Reviewed on Jul 28, 2025
Popular American Airlines Flight Routes from TYS
Top American Airlines Flight Routes from MSP
- American Airlines MSP to FRA
- American Airlines MSP to BNA
- American Airlines MSP to DFW
- American Airlines MSP to PHX
- American Airlines MSP to IAH
- American Airlines MSP to ORD
- American Airlines MSP to SEA
- American Airlines MSP to JFK
- American Airlines MSP to RSW
- American Airlines MSP to LAX
- American Airlines MSP to TPA
Top Flights for American Airlines originating from TYS
Domestic
- Newark Liberty Intl. Airport to Las Vegas (EWR - LAS)
- Chicago to Las Vegas (ORD - LAS)
- Chicago to Las Vegas (ORD - LAS)
- San Juan to Orlando (SJU - MCO)
- Los Angeles to Tokyo (LAX - HND)
- Boston to Orlando (BOS - MCO)
- New York to Santo Domingo (JFK - SDQ)
- Philadelphia to Orlando (PHL - MCO)
- Newark Liberty Intl. Airport to Las Vegas (EWR - LAS)
- Newark Liberty Intl. Airport to Santiago (EWR - STI)
International
- New York to Santiago (JFK - STI)
- Los Angeles to Tokyo (LAX - NRT)
- New York to Montego Bay (JFK - MBJ)
- Los Angeles to Tokyo (LAX - HND)
- Chicago to Las Vegas (ORD - LAS)
- Los Angeles to San Salvador (LAX - SAL)
- New York to San Juan (JFK - SJU)
- San Juan to Orlando (SJU - MCO)
- San Juan to Orlando (SJU - MCO)
- New York to San Juan (JFK - SJU)
Most Popular
- Dallas to Nashville (DFW - BNA)
- Los Angeles to Nashville (LAX - BNA)
- Nashville to New York (BNA - JFK)
- Phoenix to Minneapolis (PHX - MSP)
- Detroit to Nashville (DTW - BNA)
- JetBlue Airways Boston (BOS) to Nashville (BNA) flights
- Minneapolis to Miami (MSP - MIA)
- Delta Minneapolis - St. Paul (MSP) to Phoenix (PHX) flights
- Philadelphia to Nashville (PHL - BNA)
- Minneapolis to Denver (MSP - DEN)
- Nashville to Dallas (BNA - DFW)
- Delta Minneapolis - St. Paul (MSP) to Honolulu (HNL) flights
- Tampa to Nashville (TPA - BNA)
- Minneapolis to Phoenix (MSP - PHX)
- Minneapolis to Dallas (MSP - DFW)
- Nashville to Los Angeles (BNA - LAX)
- Minneapolis to Los Angeles (MSP - LAX)
- Minneapolis to Orlando (MSP - MCO)
- JetBlue Airways New York (JFK) to Nashville (BNA) flights
- Nashville to Orlando (BNA - MCO)
- Chicago to Nashville (ORD - BNA)
- Memphis to Orlando (MEM - MCO)
- Nashville to Miami (BNA - MIA)
- Delta Minneapolis - St. Paul (MSP) to Las Vegas (LAS) flights
- Minneapolis to Tampa (MSP - TPA)
- Denver to Minneapolis (DEN - MSP)
- Dallas to Minneapolis (DFW - MSP)
- Delta Minneapolis - St. Paul (MSP) to Seattle (SEA) flights
- Los Angeles to Minneapolis (LAX - MSP)
- Orlando to Nashville (MCO - BNA)