Book Hotels in Lupus, MO
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Top Lupus hotels

Step Back in Time Near The Missouri River
Jamestown MO
$259 nightly
The price is $275 total per night from Apr 14 to Apr 15
$275 total
Apr 14 - Apr 15
Total with taxes and fees
This cottage features a garden, laundry facilities, and barbecue grills.
Had a great time. The place was big enough for our family holiday gathering and the Kitty is the best.
Reviewed on Dec 22, 2025

Drury Plaza Hotel Columbia East
3100 Interstate 70 Dr. SE Columbia MO
$94 nightly
The price is $106 total per night from Apr 12 to Apr 13
$106 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Room was clean when we got there. Staff at the front desk were awesome. Those working the breakfast and snacks lines were great at keeping things stocked up. Only complaint I would have is that the one day we wanted our room cleaned when we were gone, the housekeepers only gave us new towels and ...
Reviewed on Apr 6, 2026

Quiet Riverfront Cottage on Missouri River
Jamestown MO
$187 nightly
The price is $199 total per night from Apr 7 to Apr 8
$199 total
Apr 7 - Apr 8
Total with taxes and fees
This cottage features a garden, laundry facilities, and barbecue grills.
Birthday getaway
Very cute place. Enjoyed our walk down to the river and watching the water flow
Reviewed on Mar 7, 2025

Country Inn & Suites by Radisson, Columbia, MO
817 N Keene St Columbia MO
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $96 total per night from Apr 12 to Apr 13
$96 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Good convenient hotel for our needs.
Reviewed on Apr 5, 2026

Wingate by Wyndham - Columbia
3101 Wingate Ct Columbia MO
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $97 total per night from Apr 12 to Apr 13
$97 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
B E D B U G S
Reviewed on Apr 6, 2026

Best Western Plus Columbia Inn
2904 Clark Lane Columbia MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Apr 12 to Apr 13
$79 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. ...
Yes excellent accomodations
Reviewed on Apr 5, 2026

Stoney Creek Hotel Columbia
2601 S Providence Rd Columbia MO
$112 nightly
The price is $127 total per night from Apr 26 to Apr 27
$127 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling for business? Take advantage of the free WiFi in public areas, laundry service, and conference ...
Parking was very good. Didn't use the var
Reviewed on Apr 4, 2026

Baymont by Wyndham Columbia, MO
2500 I 70 Dr Sw Columbia MO
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $72 total per night from Apr 12 to Apr 13
$72 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Front desk personnel were rude and charged my card twice.
Reviewed on Apr 5, 2026

Wyndham Executive Center Columbia
2200 I-70 Drive SW Columbia MO
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $127 total per night from Apr 12 to Apr 13
$127 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Clean and friendly
Reviewed on Apr 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Lupus hotel reviews by fellow wanderers

Drury Plaza Hotel Columbia East
4 out of 5
Posted 8 hours ago
Travelocity Verified Review
"Room was clean when we got there. Staff at the front desk were awesome. Those working the breakfast and snacks lines were great at keeping things stocked up. Only complaint I would have is that the one day we wanted our room cleaned when we were gone, the housekeepers only gave us new towels and took out the trash. They didn’t change sheets or make up the rest of the room, but had no problem taking the tip I had left them.
"
A verified traveler stayed at Drury Plaza Hotel Columbia East
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