Book Hotels in Dona Ana, NM

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
Apr 21 - Apr 22
Tomorrow
Apr 22 - Apr 23
This weekend
Apr 24 - Apr 26
Next weekend
May 1 - May 3

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Dona Ana hotels

Drury Inn & Suites Las Cruces

Drury Inn & Suites Las Cruces

3 out of 5
1631 Hickory Loop Las Cruces NM
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $123 total per night from May 10 to May 11
$123 total
May 10 - May 11
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Great customer service, friendly staff, food variety for breakfast and happy hour

Reviewed on Apr 21, 2026

Opens in a new windowDrury Inn & Suites Las Cruces
Comfort Suites Las Cruces I-25 North

Comfort Suites Las Cruces I-25 North

2.5 out of 5
236 N Telshor Blvd. Las Cruces NM
Fully refundable
$121 nightly
The price is $140 total per night from May 17 to May 18
$140 total
May 17 - May 18
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
We stayed one night passing through. Rooms were very clean and quite comfortable. We will probably stay another night on our travels back to Phoenix. Staff was very kind and courteous.

Reviewed on Apr 19, 2026

Opens in a new windowComfort Suites Las Cruces I-25 North
Hotel Encanto de Las Cruces

Hotel Encanto de Las Cruces

3.5 out of 5
705 S Telshor Blvd Las Cruces NM
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $154 total per night from May 10 to May 11
$154 total
May 10 - May 11
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling for business? Take advantage of the 24-hour business center, ...
I pick hotels based on reviews and amenities (restaurant/bar and breakfast). This one had wonderful reviews and a bar/restaurant. I agree that the property is very unique and has some charm. Unfortunately, it needs a bit of a refresh. Rooms were outdated- use of extensions cords for lamps, no modern ...

Reviewed on Apr 21, 2026

Opens in a new windowHotel Encanto de Las Cruces
Best Western Mission Inn

Best Western Mission Inn

2.5 out of 5
1765 S Main St Las Cruces NM
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $99 total per night from Apr 23 to Apr 24
$99 total
Apr 23 - Apr 24
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...
Breakfast was well above average! Especially the gravy. Good job, Mission Inn!

Reviewed on Apr 20, 2026

Opens in a new windowBest Western Mission Inn
Days Inn by Wyndham Las Cruces

Days Inn by Wyndham Las Cruces

2.5 out of 5
755 Avenida De Mesilla Las Cruces NM
Fully refundableReserve now, pay when you stay
$48 nightly
The price is $57 total per night from Apr 27 to Apr 28
$57 total
Apr 27 - Apr 28
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
This is a hidden gem. Everything was amazing. Will definitely stay again. I even reserved the wrong night and they approved my refund. Don't miss out, just stay.

Reviewed on Apr 21, 2026

Opens in a new windowDays Inn by Wyndham Las Cruces
La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

3 out of 5
1500 Hickory Dr Las Cruces NM
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $72 total per night from May 10 to May 11
$72 total
May 10 - May 11
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
No edges, bacon, sausage. Offered Toast, bagels, waffles, boiled eggs, mini yogurt, cereals.

Reviewed on Apr 21, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
Ramada Hotel & Conference Center by Wyndham Las Cruces

Ramada Hotel & Conference Center by Wyndham Las Cruces

3 out of 5
201 E University Avenue Las Cruces NM
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $94 total per night from May 4 to May 5
$94 total
May 4 - May 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling on business? Take advantage of the conference center, conference ...
Every was Great

Reviewed on Apr 15, 2026

Opens in a new windowRamada Hotel & Conference Center by Wyndham Las Cruces
Comfort Suites University Las Cruces

Comfort Suites University Las Cruces

2.5 out of 5
2101 S Triviz Drive Las Cruces NM
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $103 total per night from May 17 to May 18
$103 total
May 17 - May 18
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
We’ve stayed at several Comfort locations and have always felt good about it. But this location was quite disappointing. One of our rooms was quite dirty and the refrigerator still had things from someone’s else’s stay. Our other room had baby roaches going behind the wall pictures and mirror, the ...

Reviewed on Apr 14, 2026

Opens in a new windowComfort Suites University Las Cruces
La Quinta Inn by Wyndham Las Cruces Mesilla Valley

La Quinta Inn by Wyndham Las Cruces Mesilla Valley

3 out of 5
790 Avenida De Mesilla Las Cruces NM
Fully refundableReserve now, pay when you stay
$42 nightly
The price is $50 total per night from May 10 to May 11
$50 total
May 10 - May 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling on business? Take advantage of the conference space and free ...
I would not recommend staying here it’s dirty sketchy and seemed unsafe for my family there were homeless and people getting high in the parking lot in there cars with windows down if I could add videos of rooms poor conditions I would

Reviewed on Apr 21, 2026

Opens in a new windowLa Quinta Inn by Wyndham Las Cruces Mesilla Valley
Don't see what you're looking for?
See all available properties in Dona Ana
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Dona Ana?
Family getaways are where amazing memories are made, but traveling with youngsters can be difficult. These kid-friendly Dona Ana hotels offer perks that aim to keep adventurers of all ages comfortable and happy: Settle in at Casa de Vistas!! Relaxation and Spectacular Views!. It comes with a playground, a king bed and a passion for making families feel at home. Casita at the Mediterranean Palms Estate is another great choice. After a long day of exploring Dona Ana, return to your cozy room and perks like a swimming pool and a playground.
Where can I find cheap hotels in Dona Ana?
At Travelocity you'll find really nice hotels in Dona Ana at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Dona Ana rather than in Dona Ana. We may find you even better rates, too.
How do I find the best Dona Ana hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Dona Ana then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Dona Ana?
The cheapest hotel in Dona Ana is $50. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Dona Ana?
There are 372 hotels in Dona Ana on Travelocity.
What are the best hotels in Dona Ana?
Dona Ana has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Dona Ana for you!
When is the best time to visit Dona Ana?
If you want the joy of a fun-filled trip in peak season, visit Dona Ana during March, November and December. If you'd prefer the peace of off-season, book a stay during quieter months, such as February, September and October.
When is the cheapest time to stay in Dona Ana?
Based on historic data is usually the cheapest month to visit Dona Ana. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Dona Ana?
There are multiple hotels in Dona Ana that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Dona Ana. We have plenty of kid-friendly hotels in Dona Ana to choose from on Travelocity!
Why book a hotel in Dona Ana through Travelocity?
Because we have the top hotels in Dona Ana! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Dona Ana on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Dona Ana hotel reviews by fellow wanderers

La Quinta Inn by Wyndham Las Cruces Mesilla Valley

La Quinta Inn by Wyndham Las Cruces Mesilla Valley

1 out of 5
Posted 7 hours ago
Travelocity Verified Review
"I would not recommend staying here it’s dirty sketchy and seemed unsafe for my family there were homeless and people getting high in the parking lot in there cars with windows down if I could add videos of rooms poor conditions I would"
A verified traveler stayed at La Quinta Inn by Wyndham Las Cruces Mesilla Valley
La Quinta Inn by Wyndham Las Cruces Mesilla Valley

Explore More Ways to Travel with Travelocity