Book Hotels in Dona Ana, NM
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Top Dona Ana hotels

Drury Inn & Suites Las Cruces
1631 Hickory Loop Las Cruces NM
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $123 total per night from May 10 to May 11
$123 total
May 10 - May 11
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
We had a great time at Drury. We got an unexpected upgrade from a room to a suite, and boy were we pleasantly surprised. Room was clean, the bed was comfortable, the staff was good to us.
Reviewed on Apr 20, 2026

Comfort Suites Las Cruces I-25 North
236 N Telshor Blvd. Las Cruces NM
Fully refundable
$121 nightly
The price is $140 total per night from May 17 to May 18
$140 total
May 17 - May 18
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
We stayed one night passing through. Rooms were very clean and quite comfortable. We will probably stay another night on our travels back to Phoenix. Staff was very kind and courteous.
Reviewed on Apr 19, 2026

Hotel Encanto de Las Cruces
705 S Telshor Blvd Las Cruces NM
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $154 total per night from May 10 to May 11
$154 total
May 10 - May 11
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling for business? Take advantage of the 24-hour business center, ...
The staff was extremely cordial, the room was spacious and clean, the toiletries were top notch, convenient location, a "best stay" contender.
Reviewed on Apr 20, 2026

Best Western Mission Inn
1765 S Main St Las Cruces NM
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $99 total per night from Apr 23 to Apr 24
$99 total
Apr 23 - Apr 24
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...
Breakfast was well above average! Especially the gravy. Good job, Mission Inn!
Reviewed on Apr 20, 2026

Days Inn by Wyndham Las Cruces
755 Avenida De Mesilla Las Cruces NM
Fully refundableReserve now, pay when you stay
$48 nightly
The price is $57 total per night from Apr 27 to Apr 28
$57 total
Apr 27 - Apr 28
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
Breakfast ok. 1 bar of small soap. Pool was Clean. Staff very friendly
Reviewed on Apr 20, 2026

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
1500 Hickory Dr Las Cruces NM
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $72 total per night from May 10 to May 11
$72 total
May 10 - May 11
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
The room was clean but the amenities were old. The toilet was blocked and the outlet didn't work.
Reviewed on Apr 20, 2026

Ramada Hotel & Conference Center by Wyndham Las Cruces
201 E University Avenue Las Cruces NM
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $94 total per night from May 4 to May 5
$94 total
May 4 - May 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling on business? Take advantage of the conference center, conference ...
Every was Great
Reviewed on Apr 15, 2026

Comfort Suites University Las Cruces
2101 S Triviz Drive Las Cruces NM
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $103 total per night from May 17 to May 18
$103 total
May 17 - May 18
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
We’ve stayed at several Comfort locations and have always felt good about it. But this location was quite disappointing. One of our rooms was quite dirty and the refrigerator still had things from someone’s else’s stay. Our other room had baby roaches going behind the wall pictures and mirror, the ...
Reviewed on Apr 14, 2026

La Quinta Inn by Wyndham Las Cruces Mesilla Valley
790 Avenida De Mesilla Las Cruces NM
Fully refundableReserve now, pay when you stay
$42 nightly
The price is $50 total per night from May 10 to May 11
$50 total
May 10 - May 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling on business? Take advantage of the conference space and free ...
It is an old Hotel, the surroundings were sketchy. Ended up checking out after first night.
Reviewed on Apr 19, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent Dona Ana hotel reviews by fellow wanderers

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
3 out of 5
Posted 2 hours ago
Travelocity Verified Review
"The room was clean but the amenities were old. The toilet was blocked and the outlet didn't work."
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
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