Explore top 2026 5 Star Hotels in Gulf of Mexico
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Top Gulf of Mexico 5 Star hotels
The Roosevelt New Orleans, A Waldorf Astoria Hotel
130 Roosevelt Way New Orleans LA
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $198 total per night from Jun 3 to Jun 4
$198 total
Jun 3 - Jun 4
Total with taxes and fees
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
Four Seasons Hotel New Orleans
2 Canal Street New Orleans LA
Fully refundableReserve now, pay when you stay
$348 nightly
The price is $411 total per night from May 24 to May 25
$411 total
May 24 - May 25
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, laundry ...
9.6/10 Exceptional! (661 reviews)
Wonderful facility great staff. We had one small problem with one of our lunch reservations. The manager came out and fixed the issue and personally walked us to our table. Absolutely impeccable service.
Reviewed on May 15, 2026
Isla Bella Beach Resort & Spa
1 Knights Key Boulevard Marathon FL
Fully refundableReserve now, pay when you stay
$323 nightly
The price is $363 total per night from Jun 14 to Jun 15
$363 total
Jun 14 - Jun 15
Total with taxes and fees
This smoke-free hotel features a full-service spa, 5 outdoor pools, and a restaurant. Spend a day at the beach scuba diving, or relax with sun loungers and beach ...
9.2/10 Wonderful! (1,152 reviews)
The property is beautiful & the service top notch. Food was very good. High quality & food presentation superb! We would certainly stay there again
Reviewed on May 17, 2026
The Tampa EDITION
500 Channelside Dr. Tampa FL
Fully refundableReserve now, pay when you stay
$394 nightly
The price is $447 total per night from Jun 3 to Jun 4
$447 total
Jun 3 - Jun 4
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this luxury hotel. Relax with a drink at one of the 4 bars/lounges and get perks like ...
9.4/10 Exceptional! (379 reviews)
Great location and great staff!
Reviewed on May 17, 2026
The Henderson Beach Resort & Spa
200 Henderson Resort Way Destin FL
$448 nightly
The price is $506 total per night from May 20 to May 21
$506 total
May 20 - May 21
Total with taxes and fees
A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off ...
9.2/10 Wonderful! (1,005 reviews)
A very nice property with wonderful beach access
Reviewed on May 17, 2026
The Windsor Court
300 Gravier St New Orleans LA
Fully refundableReserve now, pay when you stay
$320 nightly
The price is $378 total per night from Jun 1 to Jun 2
$378 total
Jun 1 - Jun 2
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.8/10 Exceptional! (1,001 reviews)
Fantastic location, much quieter than many near the Quarter
Reviewed on May 14, 2026
The Ritz-Carlton, Sarasota
1111 Ritz Carlton Dr Sarasota FL
Fully refundableReserve now, pay when you stay
$567 nightly
The price is $640 total per night from Jun 17 to Jun 18
$640 total
Jun 17 - Jun 18
Total with taxes and fees
This smoke-free hotel features a golf course, a full-service spa, and a marina. Enjoy beachfront dining and relax with beach cabanas and sun loungers. Enjoy ...
9.2/10 Wonderful! (1,007 reviews)
Beautiful location
Reviewed on May 14, 2026
The Ritz-Carlton, New Orleans
921 Canal St New Orleans LA
Fully refundableReserve now, pay when you stay
$273 nightly
The price is $323 total per night from May 24 to May 25
$323 total
May 24 - May 25
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,001 reviews)
We had some problems with the heating/cooling in our room and someone had to come a few times to try and fix it..other than that the hotel was good.. the dinner menu in the restaurant didn’t have many options .. but the food and drinks were good. Always a cab waiting out front so transportation was ...
Reviewed on May 12, 2026
Maison Métier, in the Unbound Collection by Hyatt
546 Carondelet Street New Orleans LA
Fully refundableReserve now, pay when you stay
$322 nightly
The price is $379 total per night from May 25 to May 26
$379 total
May 25 - May 26
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, dry cleaning, and luggage storage are also offered.
9.8/10 Exceptional! (293 reviews)
My favorite hotel in downtown New Orleans. The regal accommodations paired with the bespoke speakeasy was lovely
Reviewed on May 13, 2026
The Gemma by Brightwild
19 somerset Clearwater Beach FL
$1,420 nightly
The price is $1,605 total per night from May 19 to May 20
$1,605 total
May 19 - May 20
Total with taxes and fees
This vacation home features an outdoor pool and a hot tub. Guests will appreciate free perks like free self parking and WiFi in public areas. A terrace, a garden, ...
10/10 Exceptional! (2 reviews)
Amazing property
Reviewed on Mar 15, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Gulf of Mexico Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Gulf of Mexico to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Gulf of Mexico 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Gulf of Mexico before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Gulf of Mexico hotel reviews by fellow wanderers
Margaritaville Resort Biloxi
1 out of 5
Posted 3 hours ago
Travelocity Verified Review
"We have been going to this resort for 4 years. Never had a problem. Loved it there. This year was awful. My son’s comforter was stained with either dry blood or some other bodily function. And then there was a cockroach the size of a matchbox car in our room. We tried to call the front desk 3 times and they did not answer. So my husband and son took pics of the roach and stain and went to the front desk. They were directed to a supervisor. They tried to keep low voices so none of the other guests could hear. The supervisor basically blew them off and told them to wait for the head of housekeeping. When she arrived she asked them if they would like another room. Yes! She then said we couldn’t because they were sold out. What?! Why did you offer? They said they would go back up and do a deep cleaning. They did this when we went to dinner. When we got back the roach was done and a new comforter was put on the bed. We were not offered anything and no one apologized. After we left I sent an email to their customer care. Never got a response. Tried the CEO, nothing. I found a 3rd email address and sent a message. I was asking for a refund at this point. We even left a day early. I finally got an email back instructing me to call the resort directly. Why would I do that? They didn’t do anything when I was there. Very disappointed. "
A verified traveler stayed at Margaritaville Resort Biloxi
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