Explore top 2026 4 Star Hotels in Defiance
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Top Defiance 4 Star hotels
Ameristar Casino Resort and Spa
Hilton St. Louis Frontenac
DoubleTree by Hilton Hotel St. Louis - Chesterfield
DoubleTree by Hilton St. Louis - Westport
"lights in bathroom & room could be brighter. Would be great to have a mirror over the desk in the room to sit down for makeup and not tie up bathroom. wd book room In back of hotel instead of in front by 270. Noise of trucks & cars kept me up all night.Breakfast was a joke!! Having to pay $17.99 ..."
Reviewed on Oct 1, 2026
The Inn at Elijah McLeans
"The ease of checking in digitally was nice. I like the quiet view of the river and space that was away from the streets. If you stay during the weekend you have lots of restaurants to choose from. They observe blue law so Mondays and Tuesdays are extremely quiet and you have to drive a little. We ..."
Reviewed on Sep 23, 2026
'the Ruebling House': Bright, Modern, & Renovated!
Landing Apartments - Eureka
4 Star Hotels Defiance
Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?
Come on, you deserve it!
The best part about staying in Defiance 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.
Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.
The best four star hotels in Defiance will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!
If you’re looking for 4 star hotels in Defiance, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.
Recent Defiance hotel reviews by fellow wanderers
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
"It’s a former Drury Inn property so it’s built well and pretty quiet. Room was clean and comfortable. A bit on the small size but not cramped."
