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Deals on vacations and trips to Southeast Missouri
Save when you book Southeast Missouri package deals
Southeast Missouri flight + hotel vacation packages
Price found within the past 48 hours. Click for updated prices.
![Holiday Inn Express & Suites St. Louis West - Fenton, an IHG Hotel](https://images.trvl-media.com/lodging/1000000/80000/74300/74268/1415da01_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
Holiday Inn Express & Suites St. Louis West - Fenton, an IHG Hotel
per person
Aug 16 - Aug 18
found 1 day ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/4059f405_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
The Wildwood Hotel
Save 100% on your flight
per person
Aug 16 - Aug 18
found 1 day ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like continental breakfast and free self parking.
![Ameristar Casino Resort and Spa](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/6f5c3bb0_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
Ameristar Casino Resort and Spa
Save 100% on your flight
per person
Aug 16 - Aug 18
found 1 day ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
This luxury hotel features a casino, a full-service spa, and 5 restaurants. Enjoy the 2 spa tubs and 24-hour gym, and unwind with a drink at the poolside bar.
![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
Hollywood Casino & Hotel St. Louis
per person
Aug 16 - Aug 18
found 1 day ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling for business? Take advantage of the 24-hour business center, express check-out, and conference space. Relax with a drink at one of the 3 bars/lounges and enjoy perks like free self parking.
![River City Casino & Hotel](https://images.trvl-media.com/lodging/7000000/6460000/6456500/6456459/4c09ced4_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)
River City Casino & Hotel
per person
Aug 16 - Aug 18
found 1 day ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference space. Enjoy the 24-hour gym and perks like free self parking.
Top Southeast Missouri hotels deals
![Auburn Place Hotel And Suites](https://images.trvl-media.com/lodging/1000000/980000/980000/979972/ee364310_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Auburn Place Hotel And Suites
3265 William St, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $67 per night
$67
per night
Jun 27 - Jun 28
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Pool
Breakfast included
![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/f23ff087_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
The price is $69 per night
$69
per night
Jun 20 - Jun 21
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.
Breakfast included
Pet friendly
![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/6388963b_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
The price is $77 per night
$77
per night
Jun 30 - Jul 1
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.
Pet friendly
Parking included
![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/fd7e3411_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Free Cancellation
Reserve now, pay when you stay
The price is $56 per night
$56
per night
Jul 15 - Jul 16
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included
![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/eb9ae498_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $61 per night
$61
per night
Jun 25 - Jun 26
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A gym and a safe deposit box are also provided.
Breakfast included
Pet friendly
![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
The price is $94 per night
$94
per night
Jul 7 - Jul 8
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Elephant Rocks State Park
5/5(13 reviews)
Explore the great outdoors at Elephant Rocks State Park, a lovely green space in Ironton. Make some time to visit the shops while you're in the area.
Echo Bluff State Park
4.5/5(8 reviews)
Explore the great outdoors at Echo Bluff State Park, a lovely green space in Salem. While you're in the area, stroll along the riverfront.
Lake Wappapello
4/5(18 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Photos of local treasures
Browse Southeast Missouri vacation photos for more inspiration
![Southeast Missouri](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)
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