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Top hotels in Sanctuary

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina

4 out of 5
275 Estero Blvd Fort Myers Beach FL
$287 nightly
The price is $320 total per night from May 20 to May 21
$320 total
May 20 - May 21
Total with taxes and fees
A marina, 3 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the gym and free buffet breakfast each morning. Enjoy the hot ...
Breakfast every morning was delicious and extensive. Everything in the room was immaculate. The staff is outstanding and very accommodating. Beautifulbeach, groomed every morning. Immaculate pools. Can't say enough about this outstanding resort. Don't hesitate to book your stay here... You won't ...

Reviewed on Apr 20, 2026

Opens in a new windowPink Shell Beach Resort and Marina
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 out of 5
1538 Cape Coral Pkwy E Cape Coral FL
Fully refundable
$101 nightly
The price is $113 total per night from May 10 to May 11
$113 total
May 10 - May 11
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Rbevvevec

Reviewed on Apr 20, 2026

Opens in a new windowHoliday Inn Express Cape Coral-Fort Myers Area by IHG
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $258 total per night from May 17 to May 18
$258 total
May 17 - May 18
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink ...
The room smelled like mold, but they reimbursed me for some of my stay.

Reviewed on Apr 21, 2026

Opens in a new windowSanibel Island Beach Resort
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
$271 nightly
The price is $302 total per night from Apr 28 to Apr 29
$302 total
Apr 28 - Apr 29
Total with taxes and fees
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Relax with a drink at one of the 4 bars/lounges and get perks ...
Very nice but expensive

Reviewed on Apr 21, 2026

Opens in a new windowMargaritaville Beach Resort Fort Myers
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
$188 nightly
The price is $210 total per night from Apr 28 to Apr 29
$210 total
Apr 28 - Apr 29
Total with taxes and fees
This smoke-free hotel features 3 restaurants, 3 beach bars, and 6 bars/lounges. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Enjoy ...
Didn’t need room cleaned just dirty towels removed and replaced with clean. Never happened in our 4 day stay. I asked for a clean fitted sheet and 2 clean towels on day 2 and it took 2 requests to get them. No one ever emptied trash or offered clean towels.

Reviewed on Apr 21, 2026

Opens in a new windowLani Kai Beachfront Resort
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

4 out of 5
5951 Silver King Blvd. Cape Coral FL
Fully refundableReserve now, pay when you stay
$191 nightly
The price is $213 total per night from Apr 28 to Apr 29
$213 total
Apr 28 - Apr 29
Total with taxes and fees
A full-service spa, a marina, and 2 outdoor tennis courts are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
Gorgeous property with spacious rooms for a family.

Reviewed on Apr 20, 2026

Opens in a new windowThe Westin Cape Coral Resort At Marina Village
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3 out of 5
12600 University Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $124 total per night from Apr 28 to Apr 29
$124 total
Apr 28 - Apr 29
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Very friendly staff.

Reviewed on Apr 21, 2026

Opens in a new windowHilton Garden Inn Ft Myers
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4 out of 5
17260 Harbour Pointe Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$328 nightly
The price is $366 total per night from Apr 27 to Apr 28
$366 total
Apr 27 - Apr 28
Total with taxes and fees
A full-service spa, 4 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the 5 outdoor tennis courts and indoor pool, and unwind ...
Our overall stay was great. Pool was very clean and warm. Staff was great. Amenities were good. Location is perfect.

Reviewed on Apr 21, 2026

Opens in a new windowMarriott Sanibel Harbour Resort & Spa
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

3 out of 5
20091 Summerlin Road Fort Myers FL
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $85 total per night from May 5 to May 6
$85 total
May 5 - May 6
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Great

Reviewed on Apr 21, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Sanctuary Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Sanctuary area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Sanctuary to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Sanctuary are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Sanctuary hotel reviews by fellow wanderers

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Didn’t need room cleaned just dirty towels removed and replaced with clean. Never happened in our 4 day stay. I asked for a clean fitted sheet and 2 clean towels on day 2 and it took 2 requests to get them. No one ever emptied trash or offered clean towels."
A verified traveler stayed at Lani Kai Beachfront Resort
Lani Kai Beachfront Resort

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