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Top hotels in Sanctuary

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina

4 out of 5
275 Estero Blvd Fort Myers Beach FL
$271 nightly
The price is $303 total per night from Jun 10 to Jun 11
$303 total
Jun 10 - Jun 11
Total with taxes and fees
A marina, 3 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the gym and free buffet breakfast each morning. Enjoy the hot ...
"Great Resort. Breakfast was delicious every morning. Beach is beautiful and well maintained. Staff is very friendly and helpful"

Reviewed on Jun 6, 2026

Opens in a new windowPink Shell Beach Resort and Marina
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $275 total per night from Jun 30 to Jul 1
$275 total
Jun 30 - Jul 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink ...
"Refurbished bathroom was awesome. Good bed! Nice pool snd great access to beach."

Reviewed on Jun 5, 2026

Opens in a new windowSanibel Island Beach Resort
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 out of 5
1538 Cape Coral Pkwy E Cape Coral FL
Fully refundable
$101 nightly
The price is $113 total per night from Jul 1 to Jul 2
$113 total
Jul 1 - Jul 2
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"I cannot fault the hotel. Friendly, helpful staff. Clean spacious room. Variety of things to see and good restaurants/bars nearby. Ideal....."

Reviewed on Jun 6, 2026

Opens in a new windowHoliday Inn Express Cape Coral-Fort Myers Area by IHG
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
$227 nightly
The price is $253 total per night from Jun 7 to Jun 8
$253 total
Jun 7 - Jun 8
Total with taxes and fees
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Relax with a drink at one of the 4 bars/lounges and get perks ...
"Our stay at Margaritaville Ft Myers was great. Staff is so helpful, friendly and welcoming. Everywhere was extremely clean and maintained. The decor was so pretty, made you feel like you were on a tropical vacation. The pool was really enjoyable and the access to beach was so easy. Some of the food ..."

Reviewed on Jun 6, 2026

Opens in a new windowMargaritaville Beach Resort Fort Myers
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$163 nightly
The price is $182 total per night from Jun 15 to Jun 16
$182 total
Jun 15 - Jun 16
Total with taxes and fees
This smoke-free hotel features 3 restaurants, 3 beach bars, and 6 bars/lounges. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Enjoy ...
"Customer service was top tier. Convenient, and walkable. All balconies. Food options on site. Music from 9am- 10pm"

Reviewed on Jun 6, 2026

Opens in a new windowLani Kai Beachfront Resort
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3 out of 5
12600 University Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jun 14 to Jun 15
$106 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Spa was perfect! The food at the restaurant was amazing! We will actually stop by for dinner (since we live in town) there even though we are not staying. Ribeye was absolutely amazing!"

Reviewed on Jun 6, 2026

Opens in a new windowHilton Garden Inn Ft Myers
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4 out of 5
17260 Harbour Pointe Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$270 nightly
The price is $301 total per night from Jun 7 to Jun 8
$301 total
Jun 7 - Jun 8
Total with taxes and fees
A full-service spa, 4 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the 5 outdoor tennis courts and indoor pool, and unwind ...
"El hotel es muy agradable, tiene unas vistas maravillosas, si quieres relajarte esta es una muy buena opciòn. El personal es excelente, muy atentos y con ganas de atenderte siempre eso fuè lo que mas llamò mi atenciòn."

Reviewed on Jun 5, 2026

Opens in a new windowMarriott Sanibel Harbour Resort & Spa
The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites

3 out of 5
1051 5th St Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $171 total per night from Jun 7 to Jun 8
$171 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features 2 outdoor pools, a restaurant, and a bar/lounge. Relax with a drink at the poolside bar and enjoy perks like free self parking and free WiFi. ...
"Super cute and comfy We will come back"

Reviewed on Jun 5, 2026

Opens in a new windowThe Lighthouse Resort Inn & Suites
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

3 out of 5
20091 Summerlin Road Fort Myers FL
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $97 total per night from Jun 21 to Jun 22
$97 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"The front desk clerk was very polite and helpful. Everything was clean and we enjoyed the pool right up until 10 pm."

Reviewed on Jun 4, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Sanctuary Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Sanctuary area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Sanctuary to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Sanctuary are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Sanctuary hotel reviews by fellow wanderers

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