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Top hotels in Matlacha Isles

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina

4 out of 5
275 Estero Blvd Fort Myers Beach FL
$269 nightly
The price is $300 total per night from Jul 19 to Jul 20
$300 total
Jul 19 - Jul 20
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Enjoy the 3 outdoor pools and free buffet breakfast each morning. Enjoy the ...
"Our room was very clean and 99%of the staff were happy and helpful. They really did think of almost everything and our stay was comfortable. The only negatives were that we couldn’t pay cash anywhere on the property except at the front desk. We had to charge everything to our room and go to the front ..."

Reviewed on Jun 23, 2026

Opens in a new windowPink Shell Beach Resort and Marina
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
$254 nightly
The price is $280 total per night from Jun 25 to Jun 26
$280 total
Jun 25 - Jun 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink ...
"Awesome!"

Reviewed on Jun 23, 2026

Opens in a new windowSanibel Island Beach Resort
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 out of 5
1538 Cape Coral Pkwy E Cape Coral FL
$101 nightly
The price is $113 total per night from Jun 28 to Jun 29
$113 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Clean room, great water pressure in the shower. Staff was very helpful and pleasant. Great location etc. Will definitely stay here next time we are in town."

Reviewed on Jun 24, 2026

Opens in a new windowHoliday Inn Express Cape Coral-Fort Myers Area by IHG
DiamondHead Beach Resort

DiamondHead Beach Resort

3.5 out of 5
2000 Estero Blvd Fort Myers Beach FL
$246 nightly
The price is $274 total per night from Jul 14 to Jul 15
$274 total
Jul 14 - Jul 15
Total with taxes and fees
This smoke-free resort features 2 hot tubs, an outdoor pool, and a restaurant. Dine at the beachfront restaurant and relax with beach umbrellas. Enjoy the gym ...
"Beautiful stay everything was very nice"

Reviewed on Jun 23, 2026

Opens in a new windowDiamondHead Beach Resort
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
$230 nightly
The price is $257 total per night from Jul 1 to Jul 2
$257 total
Jul 1 - Jul 2
Total with taxes and fees
A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"My husband and I had a great time on our 3 day stay, clean room and walking distance to the beach."

Reviewed on Jun 24, 2026

Opens in a new windowMargaritaville Beach Resort Fort Myers
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
$178 nightly
The price is $198 total per night from Jul 1 to Jul 2
$198 total
Jul 1 - Jul 2
Total with taxes and fees
This smoke-free hotel features 3 restaurants, 3 beach bars, and 6 bars/lounges. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Enjoy ...
"After the hurricane they refurbished it very nicely keeping the old Florida vibe!"

Reviewed on Jun 24, 2026

Opens in a new windowLani Kai Beachfront Resort
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3 out of 5
12600 University Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jul 5 to Jul 6
$106 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Had a great experience. Will stay again."

Reviewed on Jun 22, 2026

Opens in a new windowHilton Garden Inn Ft Myers
Baymont by Wyndham Fort Myers Central

Baymont by Wyndham Fort Myers Central

2.5 out of 5
4850 S Cleveland Ave Fort Myers FL
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $71 total per night from Jun 26 to Jun 27
$71 total
Jun 26 - Jun 27
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
"Place can be ok for a night stay but not recommended for a week or more, hotel needs a complete renovation its run down and so many damage stuff and rust i get its Florida and it's expensive to run a hotel specially when they have the a/c running 24/7"

Reviewed on Jun 24, 2026

Opens in a new windowBaymont by Wyndham Fort Myers Central
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4 out of 5
17260 Harbour Pointe Dr Fort Myers FL
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $266 total per night from Jul 7 to Jul 8
$266 total
Jul 7 - Jul 8
Total with taxes and fees
A full-service spa, 4 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy the 5 outdoor tennis courts and indoor pool, and unwind ...
Opens in a new windowMarriott Sanibel Harbour Resort & Spa
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Matlacha Isles Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Matlacha Isles area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Matlacha Isles to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Matlacha Isles are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Matlacha Isles hotel reviews by fellow wanderers

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"After the hurricane they refurbished it very nicely keeping the old Florida vibe!"
A verified traveler stayed at Lani Kai Beachfront Resort
Lani Kai Beachfront Resort

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