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Top East Cape Girardeau hotels

Drury Inn & Suites Jackson MO
225 Drury Lane Jackson MO
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $88 total per night from Dec 7 to Dec 8
$88 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
It was great
Reviewed on Nov 30, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Dec 11 to Dec 12
$102 total
Dec 11 - Dec 12
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Great
Reviewed on Dec 1, 2025

Courtyard by Marriott Cape Girardeau Downtown
400 Broadway St. Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $131 total per night from Dec 21 to Dec 22
$131 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
We had a great stay, the hotel is nice and clean. The staff was very friendly and welcoming!
Reviewed on Dec 1, 2025

Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Dec 10 to Dec 11
$102 total
Dec 10 - Dec 11
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
I do love this hotel chain. Another great visit!
Reviewed on Dec 2, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
Fully refundable
$95 nightly
The price is $107 total per night from Dec 22 to Dec 23
$107 total
Dec 22 - Dec 23
Total with taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly.
Reviewed on Dec 3, 2025

The Riverview
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Dec 7 to Dec 8
$105 total
Dec 7 - Dec 8
Total with taxes and fees
This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. ...
Helpful staff, clean room.
Reviewed on Nov 26, 2025

Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Dec 10 to Dec 11
$79 total
Dec 10 - Dec 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour ...
The room is very clean and there aren’t any little items that would cause me to feel frustrated. Also, the staff was very pleasant!
Reviewed on Nov 30, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $85 total per night from Jan 4 to Jan 5
$85 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Nice room and pool and fitness room. Bed a little hard and lumpy, sink drain slow, shower water pressure low, musty smell in bathroom (curtain?), pool opened too late for my aerobic exercises (8am). (Prefer bacon to sausage)
Reviewed on Dec 1, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Dec 10 to Dec 11
$79 total
Dec 10 - Dec 11
Total with taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
Welcoming staff, clean room, good breakfast, great location to the medical center.
Reviewed on Dec 2, 2025
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent East Cape Girardeau hotel reviews by fellow wanderers

Candlewood Suites Cape Girardeau by IHG
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Clean room, low noise and very comfortable!"
A verified traveler stayed at Candlewood Suites Cape Girardeau by IHG
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