Book Hotels in Cairo, IL

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Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

Tamms

This vacation home featured laundry facilities and barbecue grills.

"Wonderful little gateway! Especially to disconnect and enjoy nature. Dislike is the stairs to the loft. Everything else was great!"

Reviewed on Jun 10, 2025

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Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Kevil

This vacation home features a garden, laundry facilities, and barbecue grills.

"This cozy quiet farmhouse was the perfect place to stay for my boyfriend and I’s first getaway together. We will definitely come back again!"

Reviewed on Jun 15, 2025

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Charming cottage overlooking Lake Acre

Dongola

This cabin features a garden, laundry facilities, and barbecue grills.

Relaxing Getaway

"2nd time staying here Suzzie is a great host goes out of her way to make sure you’re happy the coffee pot went out the day after we got there didn’t look very old told her about it and that it wasn’t a big deal we just boiled some water and poured it t the filter about a half hour later she showed ..."

Reviewed on May 29, 2025

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Charming Home just minutes from Interstate and Mall

Kevil

This vacation home featured laundry facilities and barbecue grills.

Kevil Stay

"Difficult to summarize! Lovely home, very clean, attractive decor. Lots of nice amenities. This home was also close to our activities. We were very comfortable."

Reviewed on Apr 28, 2025

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Peaceful secluded cabin located near Horseshoe Lake

Miller City

This cabin features barbecue grills.

Great time great place too stay

"Wasent long enough!"

Reviewed on Jun 13, 2025

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Quality Inn Charleston - Sikeston

102 Drake St, I-57 Exit 10, Charleston, MO

Fully refundableReserve now, pay when you stay

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business ...

"Our room was spacious and bed was comfortable, took a while to cool down but eventually did, enjoyed the in-room coffee."

Reviewed on Jun 22, 2025

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Eagle Inn Charleston

2811 East Marshall Street, Charleston, MO

Fully refundableReserve now, pay when you stay

A gym is featured at this motel, along with free self parking. WiFi in public areas is free. Staff at the 24-hour front desk can provide around-the-clock ...

"Furniture missing knobs. No chair!!??? No coffee!!?? No breakfast. Nice location. Nice staff!!"

Reviewed on May 21, 2025

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Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St, Charleston, MO

Fully refundableReserve now, pay when you stay

This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. There's a computer ...

"Great"

Reviewed on May 18, 2025

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Quality Inn Cairo I-57

13201 Kessler Road, Cairo, IL

This hotel features free WiFi in public areas, free newspapers, and free self parking. Enjoy the free full breakfast each morning. A picnic area is provided ...

"It was ok. We were just passing by"

Reviewed on Jun 10, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Cairo hotels

Quality Inn Cairo I-57

13201 Kessler Road, Cairo, IL

6.4/10 (259 reviews)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Cairo with star-rating

Check Cairo Hotels by Star Rating

Cairo Hotel & Travel Guide\n

Travelocity customers dreaming about roaming in Cairo, should think about pre-booking a room as early as possible, as you won't find an abundance of room options in the vicinity of Cairo's center.

A fantastic choice for the times you want to stay within a short walk of the urban core of Cairo, is the Quality Inn.

The Quality Inn Charleston can be found about 12 miles (20 kilometers) from the town center of Cairo. Another hotel is the Super 8 Charleston MO, which is approximately 11 miles (17 kilometers) away. You might like to investigate the Americas Best Value Inn or the Quality Inn.

Once you've found the secrets of Cairo, how about you tour a little more of the area? The Southern Illinois vicinity is home to a number of great other cultural and scenic delights to offer. If you love nature, be sure to explore Southern Illinois's rural landscapes, rolling hills and prairies. In addition you could visit many of its farms. Wise travelers in this corner of United States of America often enjoy rock climbing, hiking and abseiling.

Metropolis is 30 miles (47 kilometers) to the east of Cairo and is where you'll find Super Museum and Americana Hollywood Museum. The Holiday Inn Express Metropolis and Super 8 Metropolis are a few of the great short and long-stay alternatives in Metropolis. 45 miles (76 kilometers) to the north of Cairo, you'll also find Marion, home to the Fairfield Inn and Suites by Marriott Marion and Comfort Suites Marion. Regardless of whether you're passing through or spending a few nights in Marion, be sure to check out the Kokopelli Golf Club and Marion Carnegie Library.

Just because you're taking a break from your usual habits, who's to say that you shouldn't expand your obsession with a day watching sports. Find Rent One Park 50 miles (81 kilometers) to the north of Cairo. Sports fans that hope to find a bed close to the action can select from the Holiday Inn Express Hotel & Suites Marion Northeast or the Comfort Inn Marion.

Cairo attracts visitors with some fantastic things to look at; learn more via our complete Cairo accommodation and attractions guide.

Frequently asked questions

What are the top kid-friendly hotels in Cairo?

Family vacations are where the best memories are made, but it's no secret that traveling with young ones can be challenging. These kid-friendly Cairo hotels come with perks that aim to keep old and young alike relaxed and happy: Quality Inn Cairo I-57 will help make your adventure the best one yet. It comes with an assortment of conveniences geared toward families, such as complimentary breakfast and a swimming pool. Also check out the deals at Beautiful Cabin Retreat. It offers a king bed, animal viewing activities and plenty of opportunities to spend time as a family.

Where can I find cheap hotels in Cairo?

At Travelocity you'll find really nice hotels in Cairo at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Cairo rather than in Cairo. We may find you even better rates, too.

How do I find the best Cairo hotel deals?

Simple! On Travelocity, look through the fantastic offers we've already found in Cairo then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.

How much does it cost to stay in a hotel in Cairo?

The cheapest hotel in Cairo is . This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.

How many hotels are in Cairo?

There are 22 hotels in Cairo on Travelocity.

What are the best hotels in Cairo?

Cairo has so many great hotels to choose from at Travelocity --- and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Cairo for you!

When is the best time to visit Cairo?

If you want the joy of a fun-filled trip in peak season, visit Cairo during June, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.

When is the cheapest time to stay in Cairo?

Based on historic data is usually the cheapest month to visit Cairo. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.

Are there any great family-friendly hotels in Cairo?

There are multiple hotels in Cairo that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Cairo. We have plenty of kid-friendly hotels in Cairo to choose from on Travelocity!

Why book a hotel in Cairo through Travelocity?

Because we have the top hotels in Cairo! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!

How do I cancel my hotel booking in Cairo on Travelocity?

Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Cairo hotel reviews by fellow wanderers

Quality Inn Charleston - Sikeston

5 out of 5

Posted 2 days ago

Travelocity Verified Review

"Our room was spacious and bed was comfortable, took a while to cool down but eventually did, enjoyed the in-room coffee."

A verified traveler stayed at Quality Inn Charleston - Sikeston

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

5 out of 5

Posted 8 days ago

Travelocity Verified Review

"This cozy quiet farmhouse was the perfect place to stay for my boyfriend and I’s first getaway together. We will definitely come back again! "

A verified traveler stayed at Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286